Abstract: The present disclosure relates to AAVs encoding a SOD1 targeting polynucleotide which may be used to treat amyotrophic lateral sclerosis (ALS) and delivery methods for the treatment of spinal cord related disorders including ALS.

Abstract: A system and method which may allow users, who are looking for similar products or services on a website and thus belong to an online community, to directly communicate with each other. The method may be used in eCommerce, e.g., online shopping or online auction. The method may also be used in other contexts, such as social networking and online photo albums.

Abstract: A method for operating a machine for identifying a mechanism associated with a cellular response includes identifying molecules participating in the cellular response, accessing a database containing information characterizing molecular interactions, determining pathways connecting the identified molecules participating in the response, and solving an optimization problem. The pathways comprise nodes, each representing a molecule, and edges, each connecting a pair of nodes and representing an interaction between a respective pair of molecules represented by the pair of nodes. The nodes includes a subset that represent molecules identified as participating in the cellular response.

Abstract: A method for identifying a mechanism associated with a cellular response includes identifying molecules participating in the cellular response; accessing a database containing information characterizing molecular interactions; determining pathways connecting the identified molecules participating in the cellular response; and solving an optimization problem that includes determining a subset of the molecules and interactions having a minimum aggregate cost. The pathways include, nodes, each representing a molecule, and edges, each connecting a respective pair of nodes and representing an interaction between a respective pair of molecules represented by the respective pair of nodes. Nodes from a subset of nodes represent molecules identified as participating in the cellular response.

Abstract: A method for identifying a mechanism associated with a cellular response includes identifying molecules participating in the cellular response; accessing a database containing information characterizing molecular interactions; determining pathways connecting the identified molecules participating in the cellular response; and solving an optimization problem that includes determining a subset of the molecules and interactions having a minimum aggregate cost. The pathways include, nodes, each representing a molecule, and edges, each connecting a respective pair of nodes and representing an interaction between a respective pair of molecules represented by the respective pair of nodes. Nodes from a subset of nodes represent molecules identified as participating in the cellular response.

Abstract: A system and method which may allow users, who are looking for similar products or services on a website and thus belong to an online community, to directly communicate with each other. The method may be used in eCommerce, e.g., online shopping or online auction. The method may also be used in other contexts, such as social networking and online photo albums.

Abstract: A transceiver is described that includes a power amplifier (PA), a low noise amplifier (LNA), and an impedance matching circuit having a first and second differential output node. The first and second differential output nodes are coupled to outputs of the PA and to inputs of the LNA. The impedance matching circuit provides a load impedance to the outputs of the PA. The transceiver further includes a first impedance device having an output impedance coupled between the first and second differential output nodes. In this way, the combination of the output impedance and the load impedance matches with an impedance at the inputs of the LNA.