Patents by Inventor Carol L. Miller-Graziano

Carol L. Miller-Graziano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20040034357
    Abstract: Implantable devices that deliver a drug to a target location are disclosed. In general, the devices include a portion that engages tissue near the target location and a section with an internal cavity that houses the drug. The drug can be incorporated into a controlled release agent, such as drug-polymer microspheres, which steadily or intermittently release the drug. Alternatively, instead of defining an internal cavity, the section can be formed from a material that includes the controlled release agent. The devices can be used, e.g., to deliver down-regulatory cytokines to a site of inflammation.
    Type: Application
    Filed: April 23, 2003
    Publication date: February 19, 2004
    Applicants: UNIVERSITY OF MASSACHUSETTS, a Massachusetts corporation, SMITH & NEPHEW, INC., a Delaware corporation
    Inventors: Richard M. Beane, Carol L. Miller-Graziano, Steve Ek, George Sikora, Allison Niemann, Demetrius Litwin
  • Publication number: 20010049357
    Abstract: A method of inhibiting an inflammatory response in a mammal, e.g., a human patient, is disclosed. The method includes administering a therapeutically effective amount of heat shock protein 27 (Hsp 27). The invention also includes a method of inducing in a mammal production of IL-10 and IL-12 by administering an effective amount of Hsp 27. Also disclosed is a method of using Hsp27 to promote dendritic cell maturation in vitro.
    Type: Application
    Filed: December 4, 2000
    Publication date: December 6, 2001
    Inventors: Asit K. De, Carol L. Miller-Graziano