Abstract: Implantable devices that deliver a drug to a target location are disclosed. In general, the devices include a portion that engages tissue near the target location and a section with an internal cavity that houses the drug. The drug can be incorporated into a controlled release agent, such as drug-polymer microspheres, which steadily or intermittently release the drug. Alternatively, instead of defining an internal cavity, the section can be formed from a material that includes the controlled release agent. The devices can be used, e.g., to deliver down-regulatory cytokines to a site of inflammation.

Abstract: A method of inhibiting an inflammatory response in a mammal, e.g., a human patient, is disclosed. The method includes administering a therapeutically effective amount of heat shock protein 27 (Hsp 27). The invention also includes a method of inducing in a mammal production of IL-10 and IL-12 by administering an effective amount of Hsp 27. Also disclosed is a method of using Hsp27 to promote dendritic cell maturation in vitro.