Patents by Inventor Carol M. Hamilton
Carol M. Hamilton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6800459Abstract: The present inventors have discovered that chorismate mutase and chorismate synthase are essential for plant growth. Specifically, the inhibition of chorismate mutase or chorismate synthase gene expression in plant seedlings results in severe chlorosis, reduced growth and developmental abnormalities. The inventors have proven that chorismate synthase and chorismate mutase can be used as targets for the identification of herbicides. Thus, the invention provides methods for the identification of chemicals that modulate chorismate synthase and chorismate mutase biochemical reactions. The methods of the invention are useful for the identification of herbicides and for the inhibition of plant growth and development.Type: GrantFiled: October 9, 2002Date of Patent: October 5, 2004Assignee: Paradigm Genetics, Inc.Inventors: Douglas C. Boyes, Keith R. Davis, Jeffrey P. Woessner, Jörn Görlach, Carol M. Hamilton, Neil E. Hoffman, Andreas S. Klöti, Adel Zayed, Robert A. Ascenzi
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Patent number: 6617494Abstract: Morphological markers are used in a method of visually identifying plants transformed with a nucleotide sequence (e.g., a heterologous gene). The nucleotide sequence is transformed into a plant that exhibits an abnormal phenotype for a morphological marker. If the transformation of the plant is successful, the progeny of the transformed plant will exhibit a normal phenotype. In a preferred embodiment, the plant is Arabidopsis and the morphological marker is Gl1, which is associated with trichome production on plant leaves. The method is also useful for identifying plants that are homozygous for the transformed gene, and for identifying transformants in the T2 generation that are true crosses, rather than self-crosses.Type: GrantFiled: April 11, 2001Date of Patent: September 9, 2003Assignee: Paradigm Genetics, Inc.Inventors: Douglas C. Boyes, Carol M Hamilton, Andreas Kloti, Jorn Gorlach, Neil Hoffman
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Methods for the identification of modulators of magnesium chelatase expression or activity in plants
Patent number: 6582900Abstract: The present inventors have discovered that Mg-chelatase is essential for the growth of Arabidopsis. Specifically, the inhibition of Mg-chelatase CHL H gene expression in Arabidopsis seedlings results in varying levels of chlorosis (yellowing), significantly reduced growth and developmental abnormalities. Thus, Arabidopsis Mg-chelatase can be used as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of compounds that modulate Arabidopsis Mg-chelatase expression or activity, comprising: contacting a compound with a Arabidopsis Mg-chelatase, or a subunit thereof, and detecting the presence and/or absence of binding between said compound and said Mg-chelatase, or detecting a change in Mg-chelatase expression or activity. The methods of the invention are useful for the identification of herbicides and other compounds that can modulate plant growth and development.Type: GrantFiled: September 12, 2000Date of Patent: June 24, 2003Assignee: Paradigm Genetics, Inc.Inventors: Jeffrey P. Woessner, Adel Zayed, Jörn Görlach, Douglas C. Boyes, Keith R. Davis, Carol M. Hamilton, Neil E. Hoffman, Andreas S. Kloti, Robert A. Ascenzi -
Publication number: 20030115639Abstract: Isolated nucleotide compositions and sequences are provided for Arabidopsis thaliana genes. The nucleic acid compositions find use in identifying homologous or related genes; in producing compositions that modulate the expression or function of its encoded protein, mapping functional regions of the protein; and in studying associated physiological pathways. The genetic sequences may also be used for the genetic manipulation of cells, particularly of plant cells. The encoded gene products and modified organisms are useful for screening of biologically active agents, e.g. fungicides, insecticides, etc.; for elucidating biochemical pathways; and the like.Type: ApplicationFiled: January 26, 2001Publication date: June 19, 2003Inventors: Jorn Gorlach, Yong-Qiang An, Carol M. Hamilton, Jennifer L. Price, Tracy M. Raines, Yang Yu, Joshua G. Rameaka, Amy Page, Abraham V. Mathew, Brooke L. Ledford, Jeffrey P. Woessner, William David Haas, Carlos A. Garcia, Maja Kricker, Ted Slater, Keith R. Davis, Keith Allen, Neil Hoffman, Patrick Hurban
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Publication number: 20030077687Abstract: The present inventors have discovered that chorismate mutase and chorismate synthase are essential for plant growth. Specifically, the inhibition of chorismate mutase or chorismate synthase gene expression in plant seedlings results in severe chlorosis, reduced growth and developmental abnormalities. Thus, in one aspect the invention provides compositions for the modulation of plant growth or development comprising chorismate synthase and chorismate mutase antisense and sense polynucleotides, dsRNA and ribozymes, and related expression cassettes and vectors. The compositions of the invention are particularly useful for the modulation and inhibition of plant growth. The invention further provides plants, plant cells, and seeds containing the polynucleotides of the invention.Type: ApplicationFiled: October 9, 2002Publication date: April 24, 2003Inventors: Douglas C. Boyes, Keith R. Davis, Jeffrey P. Woessner, Jorn Gorlach, Carol M. Hamilton, Neil E. Hoffman, Andreas S. Kloti, Adel Zayed, Robert A. Ascenzi
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Patent number: 6465217Abstract: The present inventors have discovered that chorismate mutase and chorismate synthase are essential for plant growth. Specifically, the inhibition of chorismate mutase or chorismate synthase gene expression in plant seedlings results in severe chlorosis, reduced growth and developmental abnormalities. Thus, in one aspect the invention provides compositions for the modulation of plant growth or development comprising chorismate synthase and chorismate mutase antisense and sense polynucleotides, dsRNA and ribozymes, and related expression cassettes and vectors. The compositions of the invention are particularly useful for the modulation and inhibition of plant growth. The invention further provides plants, plant cells, and seeds containing the polynucleotides of the invention. The inventors have proven that chorismate synthase and chorismate mutase can be used as targets for the identification of herbicides.Type: GrantFiled: July 5, 2000Date of Patent: October 15, 2002Assignee: Paradigm Genetics, Inc.Inventors: Douglas C. Boyes, Keith R. Davis, Jeffrey P. Woessner, Jörn Görlach, Carol M. Hamilton, Neil E. Hoffman, Andreas S. Klöti, Adel Zayed, Robert A. Ascenzi
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Publication number: 20020142319Abstract: Isolated nucleotide compositions and sequences are provided for Arabidopsis thaliana genes. The nucleic acid compositions find use in identifying homologous or related genes; in producing compositions that modulate the expression or function of its encoded protein, mapping functional regions of the protein; and in studying associated physiological pathways. The genetic sequences may also be used for the genetic manipulation of cells, particularly of plant cells. The encoded gene products and modified organisms are useful for screening of biologically active agents, e.g. fungicides, insecticides, etc.; for elucidating biochemical pathways; and the like.Type: ApplicationFiled: August 7, 2001Publication date: October 3, 2002Inventors: Jorn Gorlach, Yong-Qiang An, Carol M. Hamilton, Jennifer L. Price, Tracy R. Hargiss, Yang Yu, Joshua G. Rameaka, Amy Page, Abraham V. Mathew, Brooke L. Ledford, Jeffrey P. Woessner, William David Haas, Carlos A. Garcia
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Publication number: 20020106712Abstract: The present inventors have discovered that pyruvate orthophosphate dikinase (PPDK) is essential for plant growth. Specifically, the inhibition PPDK gene expression in plant seedlings results in significant developmental abnormalities, including abnormal cotyledon development, abnormal or aborted primary leaf development and significantly reduced growth. Thus, PPDK can be used as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit PPDK expression or activity, comprising: contacting a compound with a PPDK and detecting the presence and/or absence of binding between said compound and said a PPDK, or detecting a decrease in PPDK expression or activity. The methods of the invention are useful for the identification of herbicides.Type: ApplicationFiled: December 11, 2000Publication date: August 8, 2002Inventors: Andreas S. Kloti, Robert A. Ascenzi, Neil E. Hoffman, Keith R. Davis, Adel Zayed, Jorn Gorlach, Douglas C. Boyes, Jeffrey P. Woessner, Carol M. Hamilton, Maja C. Kricker
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Publication number: 20020062014Abstract: Isolated nucleotide compositions and sequences are provided for Arabidopsis thaliana genes. The nucleic acid compositions find use in identifying homologous or related genes; in producing compositions that modulate the expression or function of its encoded protein, mapping functional regions of the protein; and in studying associated physiological pathways. The genetic sequences may also be used for the genetic manipulation of cells, particularly of plant cells. The encoded gene products and modified organisms are useful for screening of biologically active agents, e.g. fungicides, insecticides, etc.; for elucidating biochemical pathways; and the like.Type: ApplicationFiled: January 26, 2001Publication date: May 23, 2002Inventors: Jorn Gorlach, Yong-Qiang An, Carol M. Hamilton, Jennifer L. Price, Tracy M. Raines, Yang Yu, Joshua G. Rameaka, Amy Page, Abraham V. Mathew, Brooke L. Ledford, Jeffrey P. Woessner, William David Haas, Carlos A. Garcia, Maja Kricker, Ted Slater, Keith R. Davis, Keith Allen, Neil Hoffman, Patrick Hurban
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Publication number: 20020059663Abstract: Isolated nucleotide compositions and sequences are provided for Arabidopsis thaliana genes. The nucleic acid compositions find use in identifying homologous or related genes; in producing compositions that modulate the expression or function of its encoded protein, mapping functional regions of the protein; and in studying associated physiological pathways. The genetic sequences may also be used for the genetic manipulation of cells, particularly of plant cells. The encoded gene products and modified organisms are useful for screening of biologically active agents, e.g. fungicides, insecticides, etc.; for elucidating biochemical pathways; and the like.Type: ApplicationFiled: January 26, 2001Publication date: May 16, 2002Inventors: Jorn Gorlach, Yong-Qiang An, Carol M. Hamilton, Jennifer L. Price, Tracy M. Raines, Yang Yu, Joshua G. Rameaka, Amy Page, Abraham V. Mathew, Brooke L. Ledford, Jeffrey P. Woessner, William David Haas, Carlos A. Garcia, Maja Kricker, Ted Slater, Keith R. Davis, Keith Allen, Neil Hoffman, Patrick Hurban
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Publication number: 20020040490Abstract: Isolated nucleotide compositions and sequences are provided for Arabidopsis thaliana genes. The nucleic acid compositions find use in identifying homologous or related genes; in producing compositions that modulate the expression or function of its encoded protein, mapping functional regions of the protein; and in studying associated physiological pathways. The genetic sequences may also be used for the genetic manipulation of cells, particularly of plant cells. The encoded gene products and modified organisms are useful for screening of biologically active agents, e.g. fungicides, insecticides, etc.; for elucidating biochemical pathways; and the like.Type: ApplicationFiled: January 26, 2001Publication date: April 4, 2002Inventors: Jorn Gorlach, Yong-Qiang An, Carol M. Hamilton, Jennifer L. Price, Tracy M. Raines, Yang Yu, Joshua G. Rameaka, Amy Page, Abraham V. Mathew, Brooke L. Ledford, Jeffrey P. Woessner, William David Haas, Carlos A. Garcia, Maja Kricker, Ted Slater, Keith R. Davis, Keith Allen, Neil Hoffman, Patrick Hurban
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Publication number: 20020040489Abstract: Isolated nucleotide compositions and sequences are provided for Arabidopsis thaliana genes. The nucleic acid compositions find use in identifying homologous or related genes; in producing compositions that modulate the expression or function of its encoded protein, mapping functional regions of the protein; and in studying associated physiological pathways. The genetic sequences may also be used for the genetic manipulation of cells, particularly of plant cells. The encoded gene products and modified organisms are useful for screening of biologically active agents, e.g. fungicides, insecticides, etc.; for elucidating biochemical pathways; and the like.Type: ApplicationFiled: January 26, 2001Publication date: April 4, 2002Inventors: Jorn Gorlach, Yong-Qiang An, Carol M. Hamilton, Jennifer L. Price, Tracy M. Raines, Yang Yu, Joshua G. Rameaka, Amy Page, Abraham V. Mathew, Brooke L. Ledford, Jeffrey P. Woessner, William David Haas, Carlos A. Garcia, Maja Kricker, Ted Slater, Keith R. Davis, Keith Allen, Neil Hoffman, Patrick Hurban
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Publication number: 20020023280Abstract: Isolated nucleotide compositions and sequences are provided for Arabidopsis thaliana genes. The nucleic acid compositions find use in identifying homologous or related genes; in producing compositions that modulate the expression or function of its encoded protein, mapping functional regions of the protein; and in studying associated physiological pathways. The genetic sequences may also be used for the genetic manipulation of cells, particularly of plant cells. The encoded gene products and modified organisms are useful for screening of biologically active agents, e.g. fungicides, insecticides, etc.; for elucidating biochemical pathways; and the like.Type: ApplicationFiled: January 26, 2001Publication date: February 21, 2002Inventors: Jorn Gorlach, Yong-Qiang An, Carol M. Hamilton, Jennifer L. Price, Tracy M. Raines, Yang Yu, Joshua G. Rameaka, Amy Page, Abraham V. Mathew, Brooke L. Ledford, Jeffrey P. Woessner, William David Haas, Carlos A. Garcia, Maja Kricker, Ted Slater, Keith R. Davis, Keith Allen, Neil Hoffman, Patrick Hurban
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Publication number: 20020023281Abstract: Isolated nucleotide compositions and sequences are provided for Arabidopsis thaliana genes. The nucleic acid compositions find use in identifying homologous or related genes; in producing compositions that modulate the expression or function of its encoded protein, mapping functional regions of the protein; and in studying associated physiological pathways. The genetic sequences may also be used for the genetic manipulation of cells, particularly of plant cells. The encoded gene products and modified organisms are useful for screening of biologically active agents, e.g. fungicides, insecticides, etc.; for elucidating biochemical pathways; and the like.Type: ApplicationFiled: January 26, 2001Publication date: February 21, 2002Inventors: Jorn Gorlach, Yong-Qiang An, Carol M. Hamilton, Jennifer L. Price, Tracy M. Raines, Yang Yu, Joshua G. Rameaka, Amy Page, Abraham V. Mathew, Brooke L. Ledford, Jeffrey P. Woessner, William David Haas, Carlos A. Garcia, Maja Kricker, Ted Slater, Keith R. Davis, Keith Allen, Neil Hoffman, Patrick Hurban
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Publication number: 20020004939Abstract: Morphological markers are used in a method of visually identifying plants transformed with a nucleotide sequence (e.g., a heterologous gene). The nucleotide sequence is transformed into a plant that exhibits an abnormal phenotype for a morphological marker. If the transformation of the plant is successful, the progeny of the transformed plant will exhibit a normal phenotype. In a preferred embodiment, the plant is Arabidopsis and the morphological marker is Gl1, which is associated with trichome production on plant leaves. The method is also useful for identifying plants that are homozygous for the transformed gene, and for identifying transformants in the T2 generation that are true crosses, rather than self-crosses.Type: ApplicationFiled: April 11, 2001Publication date: January 10, 2002Inventors: Douglas C. Boyes, Carol M. Hamilton, Andreas Kloti, Jorn Gorlach, Neil Hoffman
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Publication number: 20010044940Abstract: Isolated nucleotide compositions and sequences are provided for Arabidopsis thaliana genes. The nucleic acid compositions find use in identifying homologous or related genes; in producing compositions that modulate the expression or function of its encoded protein, mapping functional regions of the protein; and in studying associated physiological pathways. The genetic sequences may also be used for the genetic manipulation of cells, particularly of plant cells. The encoded gene products and modified organisms are useful for screening of biologically active agents, e.g. fungicides, insecticides, etc.; for elucidating biochemical pathways; and the like.Type: ApplicationFiled: January 26, 2001Publication date: November 22, 2001Inventors: Jorn Gorlach, Yong-Qiang An, Carol M. Hamilton, Jennifer L. Price, Tracy M. Raines, Yang Yu, Joshua G. Rameaka, Amy Page, Abraham V. Mathew, Brooke L. Ledford, Jeffrey P. Woessner, William David Haas, Carlos A. Garcia, Maja Kricker, Ted Slater, Keith R. Davis, Keith Allen, Neil Hoffman, Patrick Hurban