Patents by Inventor Carol M. Kinoshita

Carol M. Kinoshita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High mannose proteins and methods of making high mannose proteins
    Patent number: 10041137
    Abstract: The invention features a method of producing a high mannose glucocerebrosidase (hmGCB) which includes: providing a cell which is capable of expressing glucocerebrosidase (GCB), and allowing production of GCB having a precursor oligosaccharide under conditions which prevent the removal of at least one mannose residue distal to the pentasaccharide core of the precursor oligosaccharide of GCB, to thereby produce an hmGCB preparation. Preferably, the condition which prevents the removal of at least one mannose residue distal to the pentasaccharide core is inhibition of a class 1 processing mannosidase and/or a class 2 processing mannosidase. The invention also features an hmGCB preparation and methods of using an hmGCB preparation.
    Type: Grant
    Filed: October 17, 2006
    Date of Patent: August 7, 2018
    Assignee: SHIRE HUMAN GENETIC THERAPIES, INC.
    Inventors: Carol M. Kinoshita, Prashant Mishra, Marianne Borowski, Peter Francis Daniel
  • TREATMENT OF ALPHA-GALACTOSIDASE A DEFICIENCY
    Publication number: 20110280856
    Abstract: The invention provides highly purified ?-Gal A, and various methods for purifying it; ?-Gal A preparations with altered charge and methods for making those preparations; ?-Gal A preparations that have an extended circulating half-life in a mammalian host, and methods for making same; and methods and dosages for administering an ?-Gal A preparation to a subject.
    Type: Application
    Filed: November 11, 2010
    Publication date: November 17, 2011
    Inventors: Richard F Selden, Marianne Borowski, Carol M. Kinoshita, Douglas A. Treco
  • Nucleic acid encoding a chimeric polypeptide
    Patent number: 7122354
    Abstract: DNA molecules comprising a sequence encoding the signal peptide of hGH linked to a heterologous protein and related cells, methods and fusion proteins.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: October 17, 2006
    Assignee: Transkaryotic Therapies, Inc.
    Inventors: Richard F. Selden, Marianne Borowski, Frances P. Gillispie, Carol M. Kinoshita, Douglas A. Treco, Melanie D. Williams
  • Nucleic acid encoding a chimeric polypeptide
    Publication number: 20030152560
    Abstract: A therepeutic method whereby an individual suspected of having an &agr;-galactosidase A deficiency, such as Fabry disease, is treated either with (1) human cells that have been genetically modified to overexpress and secrete human &agr;-gal A, or (2) purified human &agr;-gal A obtained from cultured, genetically modified human cells.
    Type: Application
    Filed: December 12, 2002
    Publication date: August 14, 2003
    Applicant: Transkaryotic Therapies Inc., a Massachusetts corporation
    Inventors: Richard F. Selden, Marianne Borowski, Frances P. Gillispie, Carol M. Kinoshita, Douglas A. Treco, Melanie D. Williams
  • Treatment of alpha-galactosidase a deficiency
    Publication number: 20030113894
    Abstract: The invention provides highly purified &agr;-Gal A, and various methods for purifying it; &agr;-Gal A preparations with altered charge and methods for making those preparations; &agr;-Gal A preparations that have an extended circulating half-life in a mammalian host, and methods for making same; and methods and dosages for administering an &agr;-Gal A preparation to a subject.
    Type: Application
    Filed: June 10, 2002
    Publication date: June 19, 2003
    Applicant: Transkaryotic Therapies, Inc., a Delaware corporation
    Inventors: Richard F. Selden, Marianne Borowski, Carol M. Kinoshita, Douglas A. Treco, Melanie D. Williams, Thomas J. Schuetz, Peter F. Daniel
  • Nucleic acid encoding a chimeric polypeptide
    Patent number: 6566099
    Abstract: A therapeutic method whereby an individual suspected of having an &agr;-galactosidase A deficiency, such as Fabry disease, is treated either with (1) human cells that have been genetically modified to overexpress and secrete human &agr;-gal A, or (2) purified human &agr;-gal A obtained from cultured, genetically modified human cells.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: May 20, 2003
    Assignee: Transkaryotic Therapies, Inc.
    Inventors: Richard F. Selden, Marianne Borowski, Frances P. Gillispie, Carol M. Kinoshita, Douglas A. Treco, Melanie D. Williams
  • Treatment of alpha-galactosidase a deficiency
    Publication number: 20030077806
    Abstract: The invention provides highly purified &agr;-Gal A, and various methods for purifying it; &agr;-Gal A preparations with altered charge and methods for making those preparations; &agr;-Gal A preparations that have an extended circulating half-life in a mammalian host, and methods for making same; and methods and dosages for administering an &agr;-Gal A preparation to a subject.
    Type: Application
    Filed: June 7, 2002
    Publication date: April 24, 2003
    Applicant: Transkaryotic Therapies, Inc., a Delaware corporation
    Inventors: Richard F. Selden, Marianne Borowski, Carol M. Kinoshita, Douglas A. Treco, Melanie D. Williams, Thomas J. Schuetz, Peter F. Daniel
  • Treatment of a &agr;-galactosidase a deficiency
    Patent number: 6458574
    Abstract: The invention provides highly purified &agr;-Gal A, and various methods for purifying it; &agr;-Gal A preparations with altered charge and methods for making those preparations; &agr;-Gal A preparations that have an extended circulating half-life in a mammalian host, and methods for making same; and methods and dosages for administering an &agr;-Gal A preparation to a subject.
    Type: Grant
    Filed: March 11, 1999
    Date of Patent: October 1, 2002
    Assignee: Transkaryotic Therapies, Inc.
    Inventors: Richard F Selden, Marianne Borowski, Carol M. Kinoshita, Douglas A. Treco, Melanie D. Williams, Thomas J. Schuetz, Peter F. Daniel
  • Therapy for &agr;-galactosidase a deficiency
    Patent number: 6395884
    Abstract: A therepeutic method whereby an individual suspected of having an &agr;-galactosidase A deficiency, such as Fabry disease, is treated either with (1) human cells that have been genetically modified to overexpress and secrete human &agr;-gal A, or (2) purified human &agr;-gal A obtained from cultured, genetically modified human cells.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: May 28, 2002
    Assignee: Transkaryotic Therapies, Inc.
    Inventors: Richard F. Selden, Marianne Borowski, Frances P. Gillispie, Carol M. Kinoshita, Douglas A. Treco, Melanie D. Williams
  • Tranfected human cells expressing human .alpha.-galactosidase A protein
    Patent number: 6083725
    Abstract: A therepeutic method whereby an individual suspected of having an .alpha.-galactosidase A deficiency, such as Fabry disease, is treated either with (1) human cells that have been genetically modified to overexpress and secrete human .alpha.-gal A, or (2) purified human .alpha.-gal A obtained from cultured, genetically modified human cells.
    Type: Grant
    Filed: September 12, 1997
    Date of Patent: July 4, 2000
    Assignee: Transkaryotic Therapies, Inc.
    Inventors: Richard F. Selden, Marianne Borowski, Frances P. Gillispie, Carol M. Kinoshita, Douglas A. Treco, Melanie D. Williams