Publication number: 20090232808
Abstract: The present invention relates generally to the fields of proteins, diagnostics, therapeutics and nutrition. More particularly, the present invention provides an isolated protein molecule in or related to the tumour necrosis factor (TNF) superfamily such as TNF-a, Lymphotoxin-a (LT-a), TNFRI, TNFRII, OX40, BAFF, NGFR, Fas Ligand or chimeric molecules thereof comprising at least a portion of the protein molecule, such as TNF-a-Fc, LT-a-Fc, TNFRI-Fc, TNFRII-Fc, OX40-Fc, BAFF-Fc, NGFR-Fc, Fas Ligand-Fc; wherein the protein or chimeric molecule thereof has a profile of measurable physiochemical parameters, wherein the profile is indicative of, associated with or forms the basis of one or more pharmacological traits. The present invention further contemplates the use of the isolated protein or chimeric molecule thereof in a range of diagnostic, prophylactic, therapeutic, nutritional and/or research applications.
Type:
Application
Filed:
January 27, 2006
Publication date:
September 17, 2009
Applicant:
APOLLO LIFE SCIENCES LIMITED
Inventors:
John D. Priest, Alan D. Watts, Jason S. Whittaker, Teresa A. Domagala, Glenn R. Pilkington, Ingrid Boehm, Carol M. Y. Lee, Mei Ann Lim, Nikolien S. Thomas
Publication number: 20090175819
Abstract: The present invention relates generally to the fields of proteins, diagnostics, therapeutics and nutrition. More particularly, the present invention provides an isolated protein molecule that comprises a dimeric 4-helix bundle, such as IFN-a2B, IFN-b1, IFN-g, IL-10 or its receptor, such as IFNAR2, IL-10Ra or chimeric molecules thereof comprising at least a portion of the protein molecule, such as IFN-a2B-Fc, IFN-b1-Fc, IFN-g-Fc, IFNAR2-Fc, IL-IO-Fc, IL-10Ra-Fc; wherein the protein or chimeric molecule thereof has a profile of measurable physiochemical parameters, wherein the profile is indicative of, associated with or forms the basis of one or more pharmacological traits. The present invention further contemplates the use of the isolated protein or chimeric molecule thereof in a range of diagnostic, prophylactic, therapeutic, nutritional and/or research applications.
Type:
Application
Filed:
February 14, 2006
Publication date:
July 9, 2009
Applicant:
APOLLO LIFE SCIENCES LIMITED
Inventors:
John D. Priest, Alan D. Watts, Jason S. Whittaker, Teresa A. Domagala, Carol M. Y. Lee, Raina J. Simpson, Ingrid Boehm, Stuart Jackson, Catherine A. Liddell, Glenn R. Pilkington, Melissa Corbett