Abstract: Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

Abstract: The present disclosure relates in part to methods for treating non-uveal melanoma cancers having GNAQ or GNA11 genetic mutations that include administering a PKC small molecule inhibitor.

Abstract: The present technology relates to a method of treating one or more behavioral symptoms of autism spectrum disorder (ASD) in a subject by transdermally administering an effective amount of cannabidiol (CBD) to the subject wherein one or more behavioral symptoms of ASD are treated in the subject.

Abstract: The invention relates to a delivery system, device and method for delivering biomaterials for fracture fixation (including augmented fixation), in particular, for delivery of bone cements. The mixing system ensures the biomaterial only commences setting upon extrusion from the mixer, cannula or during injection through an appropriate internal fracture fixation device, allowing for rapid closing by the surgeon. The system also permits the surgeon to cease injecting the cement for an extended period of time before continuing the injection in another area using the same cartridge, through the simple removal of one mixer and attaching another in its place. The invention also provides a method of delivery of biomaterials to a desired implantation site.

Abstract: Methods and compositions are provided to determine if a cancer is resistant to treatment with anti-mitotic agents, including treatment with T-DM1. The methods relate to determining if the ABCC3 gene is amplified and/or overexpressed in the cancer.

Abstract: The present invention relates to an implantable device configured to deliver, to an injured bone site, components for revascularisation and bone repair, the device comprising: a first osteoconductive scaffold component adapted to hold and deliver to the injured bone site, growth factors for inducing cellular events that initiate healing; and comprising a second osteoconductive scaffold component adapted to hold and deliver to the injured bone site, viable autologous osteogenic and/or angiogenic cells, and wherein the device also comprises a third scaffold component adapted to promote bone cell proliferation and vascularity, whereby the scaffold components provide a stable mechanical environment for promoting bone cell proliferation and vascularity. The present invention also relates to a method of manufacture of the implantable device.

Abstract: Methods and compositions are provided to determine if a cancer is resistant to treatment with anti-mitotic agents, including treatment with T-DM1. The methods relate to determining if the ABCC3 gene is amplified and/or overexpressed in the cancer.

Abstract: Disclosed herein are systems and methods to integrate and manage a computer network operations (CNO) infrastructure. A framework may include CNO applications that are used to find a target computer system, breach the target, extract data therefrom and analyze the data. A CNO organization in a secure network can use the framework to maintain, manage and monitor CNO applications in an unsecured network without compromising security from counter-attacks. The framework remains engaged with targeted computer systems during routine maintenance, management and monitoring processes to mitigate loss of mission opportunities. The framework utilizes virtual instances to provision CNO capabilities for missions operations that couple the secure and unsecured networks in an asynchronous manner while allowing bidirectional communications between the framework and computers on their respective network.

Abstract: The invention relates to a delivery system, device and method for delivering biomaterials for fracture fixation (including augmented fixation), in particular, for delivery of bone cements. The mixing system ensures the biomaterial only commences setting upon extrusion from the mixer, cannula or during injection through an appropriate internal fracture fixation device, allowing for rapid closing by the surgeon. The system also permits the surgeon to cease injecting the cement for an extended period of time before continuing the injection in another area using the same cartridge, through the simple removal of one mixer and attaching another in its place. The invention also provides a method of delivery of biomaterials to a desired implantation site.

Abstract: Methods and compositions are provided to determine if a cancer is resistant to treatment with anti-mitotic agents, including treatment with T-DM1. The methods relate to determining if the ABCC3 gene is amplified and/or overexpressed in the cancer.

Abstract: Methods for treating nausea and migraine by iontophoretically administering triptan compounds are provided.

Abstract: A method of reinforcing training including training a person on a subject matter related to a task in which the task includes one or more occurrences to be performed in the future, providing a prompt during training in which the prompt is adapted to form an association with the subject matter of the training, and allowing at least one day to pass between the training and the performance of one of the occurrences of the task. The method further includes providing the prompt in a situational response optimization space where the situational response optimization space immediately precedes the performance of one of the occurrences of the task in time and space, and wherein the prompt triggers the association with the subject matter of the training to aid the person recall subject matter presented during the training while performing the task.

Abstract: Improved pharmacokinetic profiles for the iontophoretic delivery of sumatriptan are described.

Abstract: Improved pharmacokinetic profiles for the iontophoretic delivery of sumatriptan are described.

Abstract: Methods of identifying an adjuvant capable of activating dendritic cells including measuring expression level genes in skin of an animal prior to exposure to a test compound, wherein the genes are known to be upregulated or downregulated in the skin of the animal in response to topical application of dibutyl phthalate (DBP) to skin of said animal; exposing skin of an animal of the same species to the test compound; measuring expression level of the genes in the skin of the animal after exposure to the test compound; and comparing expression level of the genes measured before and after exposure to the test compound, wherein an increase or decrease in expression level of the genes following exposure to the test compound indicates that the test compound is capable of activating dendritic cells. Also included are compositions that induce dendritic cell migration and modulate expression level of genes in skin cells.

Abstract: Disclosed herein are systems and methods to integrate and manage a computer network operations (CNO) infrastructure. A framework may include CNO applications that are used to find a target computer system, breach the target, extract data therefrom and analyze the data. A CNO organization in a secure network can use the framework to maintain, manage and monitor CNO applications in an unsecured network without compromising security from counter-attacks. The framework remains engaged with targeted computer systems during routine maintenance, management and monitoring processes to mitigate loss of mission opportunities. The framework utilizes virtual instances to provision CNO capabilities for missions operations that couple the secure and unsecured networks in an asynchronous manner while allowing bidirectional communications between the framework and computers on their respective network.

Abstract: A method is provided for forming a gate contact for a compound semiconductor device. The gate contact is formed from a gate contact portion and a top or wing contact portion. The method allows for the tunablity of the size of the wing contact portion, while retaining the size of the gate contact portion based on a desired operational frequency. This is accomplished by providing for one or more additional conductive material processes on the wing contact portion to increase the cross-sectional area of the wing contact portion reducing the gate resistance, while maintaing the length of the gate contact portion to maintain the operating frequency of the device.

Abstract: Methods for treating nausea and migraine by iontophoretically administering triptan compounds are provided.

Abstract: Methods for treating nausea and migraine by iontophoretically administering triptan compounds are provided.