Patents by Inventor Carol Quon
Carol Quon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250251321Abstract: A biological imaging analyzer is described comprises a staining module configured to stain cells of a biological sample so as to produce stained cells. The analyzer also comprises a lighting module configured to illuminate the stained cells, the lighting module comprising a plurality of pulsed lights. The analyzer further comprises an imaging module configured to capture images of the stained cells. A method of flow imaging a biological sample comprises flowing the biological sample including the stained cells through an image capture region of a flowcell. The method also comprises utilizing the lighting module to illuminate the stained cells at the image capture region with the plurality of pulsed lights. The method further comprises capturing images of the stained cells at the image capture region with the imaging module.Type: ApplicationFiled: March 24, 2025Publication date: August 7, 2025Inventors: Eduardo DELGADO, Bart WANDERS, Carol QUON, Gabriel SANTOS, John MCDONALD
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Publication number: 20240027327Abstract: A biological imaging analyzer is described comprises a staining module configured to stain cells of a biological sample so as to produce stained cells. The analyzer also comprises a lighting module configured to illuminate the stained cells, the lighting module comprising a plurality of pulsed lights. The analyzer further comprises an imaging module configured to capture images of the stained cells. A method of flow imaging a biological sample comprises flowing the biological sample including the stained cells through an image capture region of a flowcell. The method also comprises utilizing the lighting module to illuminate the stained cells at the image capture region with the plurality of pulsed lights. The method further comprises capturing images of the stained cells at the image capture region with the imaging module.Type: ApplicationFiled: July 21, 2023Publication date: January 25, 2024Inventors: Eduardo DELGADO, Bart WANDERS, Carol QUON, Gabriel SANTOS, John MCDONALD
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Publication number: 20220229050Abstract: Embodiments of the present invention generally relate to methods for immobilizing a biological specimen for extended periods of time for image capture. Specific embodiments may be used to support a target specimen in a gel matrix. In some embodiments, the biological specimen may be in liquid form at elevated temperatures, a stain and/or lyse may be added to the biological specimen, and a gelling composition may added. At reduced temperatures, the gelling composition may still the biological specimen to immobilize a biological specimen for extended periods of time for image capture.Type: ApplicationFiled: May 29, 2020Publication date: July 21, 2022Inventors: Carol Quon, Bart J. Wanders, John Mcdonald
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Publication number: 20210108994Abstract: The present disclosure relates to a staining methodology employing a particle contrast agent composition. The compositions described herein are capable of rapidly staining cells in a single step. The particle contrast agent composition can be comprised of a combination of one or more particle contrast agents, one or more permeabilizing agents, and one or more fixing agents. The particle contrast agent composition can include Basic Fuchsin; at least one of Brilliant Cresyl Blue, Azure B, Crystal Violet and New Methylene Blue; one or more permeabilizing agents; and Gluteraldehyde.Type: ApplicationFiled: October 8, 2020Publication date: April 15, 2021Inventor: Carol Quon
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Patent number: 10060846Abstract: Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer. Embodiments also encompass systems, compositions, and methods for analyzing a sample containing particles. Parrticles such as blood cells can be categorized and counted by a digital image processor. A digital microscope camera can be directed, for example using certain focusing techniques, into a flowcell defining a symmetrically narrowing flowpath in which the sample stream flows in a ribbon flattened by flow and viscosity parameters between layers of sheath fluid. Blood cell images can be collected and analyzed using dynamic range extension processes and systems.Type: GrantFiled: July 10, 2017Date of Patent: August 28, 2018Assignee: Iris International, Inc.Inventors: Bart J. Wanders, Gregory A. Farrell, Thomas H. Adams, Warren Groner, Xiaodong Zhao, Brett Jordan, Jack Cremins, Carol Quon
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Publication number: 20170370820Abstract: Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer. Embodiments also encompass systems, compositions, and methods for analyzing a sample containing particles. Parrticles such as blood cells can be categorized and counted by a digital image processor. A digital microscope camera can be directed, for example using certain focusing techniques, into a flowcell defining a symmetrically narrowing flowpath in which the sample stream flows in a ribbon flattened by flow and viscosity parameters between layers of sheath fluid. Blood cell images can be collected and analyzed using dynamic range extension processes and systems.Type: ApplicationFiled: July 10, 2017Publication date: December 28, 2017Applicant: Iris International, Inc.Inventors: Bart J. Wanders, Gregory A. Farrell, Thomas H. Adams, Warren Groner, Xiaodong Zhao, Brett Jordan, Jack Cremins, Carol Quon
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Patent number: 9702806Abstract: Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer. Embodiments also encompass systems, compositions, and methods for analyzing a sample containing particles. Particles such as blood cells can be categorized and counted by a digital image processor. A digital microscope camera can be directed, for example using certain focusing techniques, into a flowcell defining a symmetrically narrowing flowpath in which the sample stream flows in a ribbon flattened by flow and viscosity parameters between layers of sheath fluid. Blood cell images can be collected and analyzed using dynamic range extension processes and systems.Type: GrantFiled: March 18, 2014Date of Patent: July 11, 2017Assignee: Iris International, Inc.Inventors: Bart J. Wanders, Gregory A. Farrell, Thomas H. Adams, Warren Groner, Xiaodong Zhao, Brett Jordan, Jack Cremins, Carol Quon
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Patent number: 9279750Abstract: The present disclosure relates to a staining methodology employing a particle contrast agent composition capable of rapidly staining cells in a single step. The particle contrast agent composition can be comprised of a combination of one or more particle contrast agents, one or more permeabilizing agents, and one or more fixing agents. The particle contrast agent composition can include Crystal Violet, New Methylene Blue, Saponin, and Gluteraldehyde.Type: GrantFiled: March 17, 2014Date of Patent: March 8, 2016Assignee: Iris International, Inc.Inventors: Jack Cremins, Carol Quon
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Publication number: 20160041083Abstract: Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer. Embodiments also encompass systems, compositions, and methods for analyzing a sample containing particles. Particles such as blood cells can be categorized and counted by a digital image processor. A digital microscope camera can be directed, for example using certain focusing techniques, into a flowcell defining a symmetrically narrowing flowpath in which the sample stream flows in a ribbon flattened by flow and viscosity parameters between layers of sheath fluid. Blood cell images can be collected and analyzed using dynamic range extension processes and systems.Type: ApplicationFiled: March 18, 2014Publication date: February 11, 2016Inventors: Bart J. WANDERS, Gregory A. FARRELL, Thomas H. ADAMS, Warren GRONER, Xiaodong ZHAO, Brett JORDAN, Jack CREMINS, Carol QUON
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Publication number: 20140273081Abstract: The present disclosure relates to a staining methodology employing a particle contrast agent composition capable of rapidly staining cells in a single step. The particle contrast agent composition can be comprised of a combination of one or more particle contrast agents, one or more permeabilizing agents, and one or more fixing agents. The particle contrast agent composition can include Crystal Violet, New Methylene Blue, Saponin, and Gluteraldehyde.Type: ApplicationFiled: March 17, 2014Publication date: September 18, 2014Applicant: IRIS INTERNATIONAL, INC.Inventors: Jack Cremins, Carol Quon