Patents by Inventor Carol Schembri

Carol Schembri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140141438
    Abstract: A microfluidic device may include a sample distribution network including a plurality of sample chambers configured to be loaded with biological sample for biological testing of the biological sample while in the sample chambers, the biological sample having a meniscus that moves within the sample chambers during loading. The sample distribution network may further include a plurality of inlet channels, each inlet channel being in flow communication with and configured to flow biological sample to a respective sample chamber, and a plurality of outlet channels, each outlet channel being in flow communication and configured to flow biological sample from a respective sample chamber. At least some of the sample chambers may include a physical modification configured to control the movement of the meniscus so as to control bubble formation within the at least some sample chambers.
    Type: Application
    Filed: October 15, 2013
    Publication date: May 22, 2014
    Applicant: APPLIED BIOSYSTEMS, LLC
    Inventors: Maengseok Song, Joon Mo Yang, Julie C. Lee, Nigel P. Beard, Yuh-Min Chiang, Roy H. Tan, Carol Schembri
  • Publication number: 20070280857
    Abstract: A microfluidic device may include a sample distribution network including a plurality of sample chambers configured to be loaded with biological sample for biological testing of the biological sample while in the sample chambers, the biological sample having a meniscus that moves within the sample chambers during loading. The sample distribution network may further include a plurality of inlet channels, each inlet channel being in flow communication with and configured to flow biological sample to a respective sample chamber, and a plurality of outlet channels, each outlet channel being in flow communication and configured to flow biological sample from a respective sample chamber. At least some of the sample chambers may include a physical modification configured to control the movement of the meniscus so as to control bubble formation within the at least some sample chambers.
    Type: Application
    Filed: June 2, 2006
    Publication date: December 6, 2007
    Applicant: APPLERA CORPORATION
    Inventors: Maengseok Song, Joon Mo Yang, Julie C. Lee, Nigel P. Beard, Yuh-Min Chiang, Roy H. Tan, Carol Schembri
  • Publication number: 20070280856
    Abstract: A microfluidic device may include a sample distribution network including a plurality of sample chambers configured to be loaded with biological sample for biological testing of the biological sample while in the sample chambers, the biological sample having a meniscus that moves within the sample chambers during loading. The sample distribution network may further include a plurality of inlet channels, each inlet channel being in flow communication with and configured to flow biological sample to a respective sample chamber, and a plurality of outlet channels, each outlet channel being in flow communication and configured to flow biological sample from a respective sample chamber. At least some of the sample chambers may include a physical modification configured to control the movement of the meniscus so as to control bubble formation within the at least some sample chambers.
    Type: Application
    Filed: June 2, 2006
    Publication date: December 6, 2007
    Applicant: APPLERA CORPORATION
    Inventors: Umberto Ulmanella, Eric S. Nordman, Maengseok Song, Joon Mo Yang, Julie C. Lee, Nigel P. Beard, Min Yue, Carol Schembri, David Liu
  • Publication number: 20070202008
    Abstract: Systems and methods for nanopore flow cells are provided.
    Type: Application
    Filed: February 28, 2006
    Publication date: August 30, 2007
    Inventors: Carol Schembri, May Tom-Moy
  • Publication number: 20070201021
    Abstract: An apparatus for holding liquid samples.
    Type: Application
    Filed: September 13, 2005
    Publication date: August 30, 2007
    Inventors: Carol Schembri, Zhenghua Ji, Hongfeng Yin, William McAllister
  • Publication number: 20070134799
    Abstract: The invention relates to a method and an apparatus for performing an assay on chemical, biochemical, or biological fluids. The apparatus includes an assay chamber for fluid reactions and a centrifugal force activated-valve for controlling fluid movement through the assay chamber. An active surface can be positioned in the assay chamber to react with fluids passed through the assay chamber. The active surface may contain biomolecular probes. The biomolecular probes can be DNA, DNA fragments, RNA, RNA fragments, reagents, protein, protein fragments, lipids, and lipid fragments. The apparatus is particularly useful when multiple reactions, dilutions, or washing steps are required to determine a final answer. The centrifugal force activated-valve provides positive control over fluid in the assay chamber and allows for repeated use of the same chamber for multiple reaction steps. The apparatus can be disposed of after an assay to eliminate potential contamination from reuse of the same apparatus.
    Type: Application
    Filed: January 31, 2007
    Publication date: June 14, 2007
    Inventor: Carol Schembri
  • Publication number: 20070081155
    Abstract: The present invention relates to an apparatus for handling a liquid sample, wherein the apparatus includes integrated sample processing and sample evaluating components.
    Type: Application
    Filed: August 30, 2005
    Publication date: April 12, 2007
    Inventors: Carol Schembri, Zhenghua Ji, Hongfeng Yin, William McAllister
  • Publication number: 20070020146
    Abstract: A nanopore structure for conducting analysis on a molecule in solution. The nanopore structure includes an electrically insulating substrate and a membrane contacting the electrically insulating substrate. A nanopore is defined through the electrically insulating substrate and the membrane for conducting analysis on a molecule being positioned in the nanopore. Also disclosed are methods for making and using the nanopore structures.
    Type: Application
    Filed: June 29, 2005
    Publication date: January 25, 2007
    Inventors: James Young, Carol Schembri
  • Publication number: 20060281193
    Abstract: A test zone is read. Conjugate material is exposed to a sample. The conjugate material, when conjugated with at least one analyte in the sample, forms either electrically detectable conjugated material or magnetically detectable conjugated material. Conjugated material in the sample is captured in a test zone. A test is performed on the conjugated material captured in the test zone in order to detect analyte in the sample. The test is an electrical measurement, or a magnetic measurement.
    Type: Application
    Filed: June 9, 2005
    Publication date: December 14, 2006
    Inventors: John Petrilla, Carol Schembri, Peter Robrish
  • Publication number: 20060223194
    Abstract: The invention provides methods of analyzing a sample. In general, the methods involve: a) depositing sub-fractions of a multi-dimensionally fractionated sample into wells of a multi-well substrate; b) contacting each of the deposited sub-fractions with an array to produce a set of sub-fraction-contacted arrays; and c) interrogating the sub-fraction-contacted arrays to identify a sub-fraction containing a post-translationally modified analyte. Also provided are systems and kits for performing the subject methods.
    Type: Application
    Filed: April 1, 2005
    Publication date: October 5, 2006
    Inventors: Viorica Lopez-Avila, Carol Schembri
  • Publication number: 20060141507
    Abstract: Methods and devices are disclosed for microarray analysis. In one embodiment a method is disclosed for processing a non-standard size slide having an array of chemical compounds attached to a surface of the slide. A sample is exposed to the surface of the non-standard size slide wherein components in the sample bind to the chemical compounds on the surface of the slide. The sample and the slide are incubated under conditions for carrying out the binding reactions, and the surface of the non-standard size slide is examined for the results of the binding reactions. Prior to the exposing step or the incubating step or the examining step, the non-standard size slide is placed into a slide holder comprising a slide-holding section a slide-holding section adapted to dispose the non-standard size slide to a processing instrument in a manner similar to that for a standard size slide. The non-standard size slide may also include an identifier such as a bar code.
    Type: Application
    Filed: November 28, 2005
    Publication date: June 29, 2006
    Inventors: Mel Kronick, Bernett Saunders, Matthew Marton, John Hinchcliffe, Dianne Rees, Carol Schembri
  • Publication number: 20060078463
    Abstract: Array assay devices and methods for using the same in array based assays are provided. The subject devices are characterized by having a bottom surface, a substrate receiving element and a compression element for holding the bottom surface in a fixed position relative to a substrate received by the receiving element. The subject invention also includes methods for performing an array assay. In the subject methods, a subject device is provided and a substrate having at least one array is placed in the receiving element. The bottom surface of the device is compressed by the compression element so as to fix its position relative to the substrate and a sample is contacted to the at least one array. The subject invention also includes kits which include the subject devices.
    Type: Application
    Filed: September 26, 2005
    Publication date: April 13, 2006
    Inventors: Laurence Shea, Carol Schembri, Douglas Summers, Richard Hilson
  • Publication number: 20050250129
    Abstract: The invention provides an apparatus and method for conducting chemical or biochemical reactions on a solid surface within an enclosed chamber. The invention may be used in conducting hybridization reactions, as of biopolymers such as DNA, RNA, oligonucleotides, peptides, polypeptides, proteins, antibodies, and the like. In another aspect, the invention provides an improved method for mixing a thin film of solution, as in a hybridization chamber. The invention further provides a kit for carrying out the methods of the invention.
    Type: Application
    Filed: January 21, 2005
    Publication date: November 10, 2005
    Inventors: Carol Schembri, Leslie Overman, Charles Hotz
  • Publication number: 20050244972
    Abstract: Apparatus and methods are disclosed for processing samples on the surface of supports that are contained in support housings. Biopolymer features are attached to the surfaces of the supports. An apparatus comprises an input element, a holding device for holding a plurality of support housings, one or more fluid dispensing stations, and an output element. Each of the support housings contains a support having attached thereto a plurality of biopolymer features. The holding device is movably mounted with respect to other components of the apparatus. The holding device is adapted to receive a support housing from the input element. The output element is adapted to receive a support housing from the holding device. The apparatus is adapted to index each support housing for a predetermined operation. In use, each of the support housings is moved to one or more processing stations by means of the movable holding device. The location and identity of each of the support housings is indexed.
    Type: Application
    Filed: April 13, 2005
    Publication date: November 3, 2005
    Inventors: Richard Hilson, Edward Donlon, Donald Schremp, Laurence Shea, Carol Schembri, Joseph Fredrick
  • Publication number: 20050214854
    Abstract: A method of testing multiple fluid samples with multiple biopolymer arrays. A cover is assembled to a contiguous substrate carrying on a first side, multiple arrays each with multiple regions of biopolymers linked to the substrate, such that the cover and the substrate together form a plurality of chambers each containing a biopolymer array and each being accessible through its own port. Multiple fluid samples are introduced into respective chambers through a port of each such that the fluid samples contact respective arrays. A binding pattern of the arrays is observed. An apparatus and kit useful in such methods, are also provided.
    Type: Application
    Filed: May 23, 2005
    Publication date: September 29, 2005
    Inventors: SueAnn Dahm, Arthur Schleifer, Carol Schembri, Douglas Amorese
  • Publication number: 20050208541
    Abstract: Methods, apparatus, and computer program products to form arrays of polymers each having a pattern of features on a surface of a flexible elongated web, comprising. In a method polymers or their precursor units are applied at an application station to the surface. Multiple features are covered at a reagent station with a continuous volume of reagent which chemically reacts with precursors or the web. The flexible elongated web is driven in a lengthwise direction through the application station. This sequence may be repeated as needed to form the arrays along the web. Also provided is a method preparing a surface of a flexible elongated web to receive a biopolymer array.
    Type: Application
    Filed: January 5, 2005
    Publication date: September 22, 2005
    Inventors: Steven Lefkowitz, Michel Perbost, Roy Kanemoto, Carol Schembri
  • Publication number: 20050191700
    Abstract: Methods and compositions are provided for producing arrays of polymeric binding agents. In the subject methods, the individual polymers of the array are synthesized using solid phase synthesis techniques on the surface of a substrate. A critical feature of the invention is that one or more locations on the substrate surface are spatially and temporally protected by a protective bubble during the synthesis protocol, where the protective bubble may be produced using any convenient bubble producing means. The bubble producing means may be a component of either a substrate or a structure separate from the substrate. Also provided are the arrays produced by the subject methods, kits for use in practicing the subject methods, and methods of using the arrays in analyte detection assays, including hybridization assays, such as gene discovery, differential gene expression and gene sequencing assays.
    Type: Application
    Filed: April 28, 2005
    Publication date: September 1, 2005
    Inventor: Carol Schembri
  • Publication number: 20050186598
    Abstract: A method of reading an array of moieties such as polynucleotides (for example, DNA) on at least a portion of a surface of a transparent slide which is opposite a first portion on the opposing surface, which array has been previously exposed to a sample. The method may include mounting the slide on a slide holder and retaining the slide thereon in a mounted position in which the holder does not contact the previously exposed array. The holder is then inserted into an array reader and the array read. A holder and slides which can be used in the method are also provided.
    Type: Application
    Filed: January 5, 2005
    Publication date: August 25, 2005
    Inventors: Carol Schembri, Kimberly Tam
  • Publication number: 20050147975
    Abstract: Methods for amplifying RNA from genomic DNA are provided. In the subject methods, a promoter-primer having a primer domain linked to an RNA polymerase promoter domain is first annealed to genomic DNA. The primer domain of the resultant annealed promoter-primer/genomic DNA complex is then extended to produce a double-stranded DNA molecule that has an RNA polymerase promoter domain. The resultant double-stranded DNA molecule is then transcribed into RNA product, e.g., labeled RNA product, using an RNA polymerase that is able to transcribe through the gap between the 5? terminus of the promoter domain and the 3? side of the genomic template. The subject methods find use a variety of different applications in which the preparation of amplified amounts of RNA from a genomic template is desired, where the amplification may be linear or geometric and may amplify the entire genome or only a select portion thereof. Also provided are kits for practicing the subject methods.
    Type: Application
    Filed: December 24, 2003
    Publication date: July 7, 2005
    Inventors: Carol Schembri, Leslie Leonard
  • Publication number: 20050116986
    Abstract: A method is described for removing residue from a fluid deposited on the interior surface of an inkjet printhead after the printhead has contained or dispensed the fluid at least once. The method makes use of a reverse flushing technique optionally used in combination with sonication. A cleaning station for flushing an inkjet printhead with a wash fluid, rinse fluid, and/or inert gas is provided as well.
    Type: Application
    Filed: September 27, 2004
    Publication date: June 2, 2005
    Inventors: Michael Caren, Carol Schembri