Patents by Inventor Carol T. Schembri

Carol T. Schembri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190099908
    Abstract: The present disclosure related to apparatus and methods for removing waste of debris from a microtome blade, a microtome blade holder, or both. The invention also relates to automated systems and methods for cleaning a microtome.
    Type: Application
    Filed: October 3, 2018
    Publication date: April 4, 2019
    Inventors: Kyle Schleifer, Carol T Schembri, Young-Ping Hwung
  • Publication number: 20180231470
    Abstract: A multiple analyte detection system includes a carrier having reagents disposed thereat, with each of the reagents capable of optically changing in response to exposure to a respective analyte. The system further includes a photodetector positioned to collectively detect light interacted with each of the reagents, a processor to determine a presence or an absence of each of the analytes in response to the light collectively-detected, and an indicator to provide an indication of the presence or the absence of each of the analytes. A method of detecting multiple analytes includes exposing reagents capable of optically changing in response to exposure to a respective analyte to a sample. The method further includes collectively detecting light interacted with each of the reagents, determining a presence or an absence of each of the analytes in response to the light collectively detected, and indicating the presence or the absence of each of the analytes determined.
    Type: Application
    Filed: April 16, 2018
    Publication date: August 16, 2018
    Inventors: Ian Hardcastle, Carol T. Schembri, John Francis Petrilla, Rene B. Helbing, Daniel B. Roitman
  • Publication number: 20180120207
    Abstract: Paraffin-embedded tissue, which may be disposed on a solid substrate, is prepared by a dry technique that removes paraffin from tissue without adding any liquid to the tissue, thereby rendering the tissue substantially free of paraffin. The dry technique may entail applying heat energy to the tissue effective to melt the paraffin and thereby render it flowable, and applying an electric field. The electric field is effective to impart electrical charge to the paraffin and to move the paraffin out from the tissue due to electrical charge repulsion or attraction, which may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. The electric field, or both the electric field and the heat energy, may be applied until the tissue is substantially free of paraffin.
    Type: Application
    Filed: October 30, 2017
    Publication date: May 3, 2018
    Inventors: Victor Lim, Carol T. Schembri, Adrienne Mccampbell, Nazumi Alice Yama-Dang
  • Patent number: 9945789
    Abstract: A multiple analyte detection system includes a carrier having reagents disposed thereat, with each of the reagents capable of optically changing in response to exposure to a respective analyte. The system further includes a photodetector positioned to collectively detect light interacted with each of the reagents, a processor to determine a presence or an absence of each of the analytes in response to the light collectively-detected, and an indicator to provide an indication of the presence or the absence of each of the analytes. A method of detecting multiple analytes includes exposing reagents capable of optically changing in response to exposure to a respective analyte to a sample. The method further includes collectively detecting light interacted with each of the reagents, determining a presence or an absence of each of the analytes in response to the light collectively detected, and indicating the presence or the absence of each of the analytes determined.
    Type: Grant
    Filed: January 16, 2007
    Date of Patent: April 17, 2018
    Assignee: Alverix, Inc.
    Inventors: Ian Hardcastle, Carol T. Schembri, John Francis Petrilla, Rene B. Helbing, Daniel B. Roitman
  • Patent number: 8570518
    Abstract: A test system includes an optical medium, a binding agent capable of capturing a target complex, and a light detector. The optical medium provides a light path, and the binding agent is positioned to hold the target complex in an evanescent field created by propagation of light along the light path. The complex interacts with the evanescent field and emits light that the detector positioned to detect. The optical medium and the detector can be included in an optical integrated circuit where detected light passes through the optical medium transverse to the direction of the light path.
    Type: Grant
    Filed: January 31, 2007
    Date of Patent: October 29, 2013
    Assignee: Alverix, Inc.
    Inventors: Nicholas M. Sampas, Rene P. Helbing, Bo U. Curry, Julie E. Fouquet, Carol T. Schembri
  • Patent number: 8012765
    Abstract: A method and apparatus is provided for mixing a film of fluid, particularly a film of chemical, biochemical, or biological fluids undergoing a reaction. The apparatus comprises a means for nucleating a bubble using a discrete heat source, such as a resistor, and moving the bubble in the fluid by creating a temperature gradient, thereby mixing the fluid.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: September 6, 2011
    Assignee: Agilent Technologies, Inc.
    Inventor: Carol T. Schembri
  • Patent number: 7998411
    Abstract: The present invention provides centrifugal rotors for delivering a premeasured volume of liquid to a chamber in the rotor. In particular the rotors comprise siphons for delivering a premeasured volume of liquid between a first and a second chamber in the rotor. The siphons of the invention are designed such that the inlet of the siphon on the first chamber is radially outward of the siphon outlet on the second chamber. The first chamber is emptied to a level equivalent to the radial position of the siphon outlet.
    Type: Grant
    Filed: May 5, 2004
    Date of Patent: August 16, 2011
    Assignee: ABAXIS, Inc.
    Inventors: Anne R. Kopf-Sill, Carol T. Schembri
  • Publication number: 20100248982
    Abstract: A method and apparatus is provided for mixing a film of fluid, particularly a film of chemical, biochemical, or biological fluids undergoing a reaction. The apparatus comprises a means for nucleating a bubble using a discrete heat source, such as a resistor, and moving the bubble in the fluid by creating a temperature gradient, thereby mixing the fluid.
    Type: Application
    Filed: April 2, 2010
    Publication date: September 30, 2010
    Inventor: Carol T. Schembri
  • Patent number: 7642097
    Abstract: Methods and devices are disclosed for microarray analysis. In one embodiment a method is disclosed for processing a non-standard size slide having an array of chemical compounds attached to a surface of the slide. A sample is exposed to the surface of the non-standard size slide wherein components in the sample bind to the chemical compounds on the surface of the slide. The sample and the slide are incubated under conditions for carrying out the binding reactions, and the surface of the non-standard size slide is examined for the results of the binding reactions. Prior to the exposing step or the incubating step or the examining step, the non-standard size slide is placed into a slide holder comprising a slide-holding section a slide-holding section adapted to dispose the non-standard size slide to a processing instrument in a manner similar to that for a standard size slide. The non-standard size slide may also include an identifier such as a bar code.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: January 5, 2010
    Assignee: Agilent Technologies, Inc.
    Inventors: Mel N. Kronick, Barnett E. Saunders, Matthew J. Marton, John S. Hinchcliffe, Dianne Rees, Carol T. Schembri
  • Patent number: 7537936
    Abstract: A method of testing multiple fluid samples with multiple biopolymer arrays. A cover is assembled to a contiguous substrate carrying on a first side, multiple arrays each with multiple regions of biopolymers linked to the substrate, such that the cover and the substrate together form a plurality of chambers each containing a biopolymer array and each being accessible through its own port. Multiple fluid samples are introduced into respective chambers through a port of each such that the fluid samples contact respective arrays. A binding pattern of the arrays is observed. An apparatus and kit useful in such methods, are also provided.
    Type: Grant
    Filed: May 23, 2005
    Date of Patent: May 26, 2009
    Assignee: Agilent Technologies, Inc.
    Inventors: SueAnn C. Dahm, Arthur Schleifer, Carol T. Schembri, Douglas A. Amorese
  • Patent number: 7462450
    Abstract: Methods, apparatus, and computer program products to form arrays of polymers each having a pattern of features on a surface of a flexible elongated web, comprising. In a method polymers or their precursor units are applied at an application station to the surface. Multiple features are covered at a reagent station with a continuous volume of reagent which chemically reacts with precursors or the web. The flexible elongated web is driven in a lengthwise direction through the application station. This sequence may be repeated as needed to form the arrays along the web. Also provided is a method preparing a surface of a flexible elongated web to receive a biopolymer array.
    Type: Grant
    Filed: January 5, 2005
    Date of Patent: December 9, 2008
    Assignee: Agilent Technologies, Inc.
    Inventors: Steven M. Lefkowitz, Michel G. M. Perbost, Roy H. Kanemoto, Carol T. Schembri
  • Publication number: 20080279037
    Abstract: A method and apparatus is provided for mixing a film of fluid, particularly a film of chemical, biochemical or biological fluids undergoing a reaction. The apparatus comprises a means for nucleating a bubble using a discrete heat source, such as a resistor, and moving the bubble in the fluid by creating a temperature gradient thereby mixing the fluid.
    Type: Application
    Filed: May 5, 2008
    Publication date: November 13, 2008
    Inventor: Carol T. SCHEMBRI
  • Publication number: 20080261826
    Abstract: Methods and devices are disclosed for microarray analysis. In one embodiment a method is disclosed for processing a non-standard size slide having an array of chemical compounds attached to a surface of the slide. A sample is exposed to the surface of the non-standard size slide wherein components in the sample bind to the chemical compounds on the surface of the slide. The sample and the slide are incubated under conditions for carrying out the binding reactions, and the surface of the non-standard size slide is examined for the results of the binding reactions. Prior to the exposing step or the incubating step or the examining step, the non-standard size slide is placed into a slide holder comprising a slide-holding section a slide-holding section adapted to dispose the non-standard size slide to a processing instrument in a manner similar to that for a standard size slide. The non-standard size slide may also include an identifier such as a bar code.
    Type: Application
    Filed: June 27, 2008
    Publication date: October 23, 2008
    Inventors: Mel N. Kronick, Barnett E. Saunders, Matthew J. Marton, John S. Hinchcliffe, Dianne Rees, Carol T. Schembri
  • Patent number: 7422911
    Abstract: Flexible array substrates having a flexible support, a flexible base, a reflective layer, and a transparent layer, in that order, are taught. Methods of forming the flexible array substrates, devices incorporating flexible array substrates, and arrays having probes arranged on a surface of the flexible array substrate are also taught.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: September 9, 2008
    Assignee: Agilent Technologies, Inc.
    Inventor: Carol T. Schembri
  • Publication number: 20080180673
    Abstract: A test system includes an optical medium, a binding agent capable of capturing a target complex, and a light detector. The optical medium provides a light path, and the binding agent is positioned to hold the target complex in an evanescent field created by propagation of light along the light path. The complex interacts with the evanescent field and emits light that the detector positioned to detect. The optical medium and the detector can be included in an optical integrated circuit where detected light passes through the optical medium transverse to the direction of the light path.
    Type: Application
    Filed: January 31, 2007
    Publication date: July 31, 2008
    Inventors: Nicholas M. Sampas, Rene P. Helbing, Bo U. Curry, Julie E. Fouquet, Carol T. Schembri
  • Patent number: 7402279
    Abstract: Devices having microfluidic features and arrays joined to electronics components are described. In an embodiment, the array includes a flexible array substrate. The electronics components have circuitry that may e.g. detect reactions or control conditions on the device via a feedback loop. Modular architecture provides for different combinations of microfluidic components, array components, and/or electronics components that can be used to create customized processing and analysis tools.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: July 22, 2008
    Assignee: Agilent Technologies, Inc.
    Inventor: Carol T Schembri
  • Publication number: 20080171397
    Abstract: A multiple analyte detection system includes a carrier having reagents disposed thereat, with each of the reagents capable of optically changing in response to exposure to a respective analyte. The system further includes a photodetector positioned to collectively detect light interacted with each of the reagents, a processor to determine a presence or an absence of each of the analytes in response to the light collectively-detected, and an indicator to provide an indication of the presence or the absence of each of the analytes. A method of detecting multiple analytes includes exposing reagents capable of optically changing in response to exposure to a respective analyte to a sample. The method further includes collectively detecting light interacted with each of the reagents, determining a presence or an absence of each of the analytes in response to the light collectively detected, and indicating the presence or the absence of each of the analytes determined.
    Type: Application
    Filed: January 16, 2007
    Publication date: July 17, 2008
    Inventors: Ian Hardcastle, Carol T. Schembri, John Francis Petrilla, Rene B. Helbing, Daniel B. Roitman
  • Patent number: 7390457
    Abstract: A microfluidic component having a microfluidic channel is joined to an array component having a flexible array substrate. In an embodiment, the array component includes a prefabricated flexible array that couples with the microfluidic component in modular fashion. The modular architecture provides for different combinations of microfluidic components and array components that can be used to create customized processing and analysis tools.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: June 24, 2008
    Assignee: Agilent Technologies, Inc.
    Inventor: Carol T Schembri
  • Patent number: 7371349
    Abstract: A method and apparatus is provided for mixing a film of fluid, particularly a film of chemical, biochemical, or biological fluids undergoing a reaction. The apparatus comprises a means for nucleating a bubble using a discrete heat source, such as a resistor, and moving the bubble in the fluid by creating a temperature gradient, thereby mixing the fluid.
    Type: Grant
    Filed: February 4, 2003
    Date of Patent: May 13, 2008
    Assignee: Agilent Technologies, Inc.
    Inventor: Carol T. Schembri
  • Patent number: 7364896
    Abstract: Individual and aggregate test strip arrays having a backing strip supporting a flexible array substrate which supports an addressable collection of probes are taught. Hybridization cells for use with the individual test strip arrays are also disclosed, and in particular embodiments the hybridization cells closely fit a portion or all of the individual test strip arrays. Array hybridization systems that include test strip arrays and hybridization cells are disclosed with methods for performing a hybridization assay on a sample solution.
    Type: Grant
    Filed: October 31, 2002
    Date of Patent: April 29, 2008
    Assignee: Agilent Technologies, Inc.
    Inventor: Carol T. Schembri