Abstract: Image sensor systems are disclosed that allow for charge transfer between pixels of a group included in a pixel array with a single digital readout of the accumulated charge from the group. Each of the pixels within a given group includes a photodetector. One or more pump gates are arranged between adjacent pixels of the given group to allow charge to be pumped from one pixel to the next in a serial fashion within the group. A readout circuit that includes at least a transfer gate and a capacitor may be coupled to a final pixel of the group to receive the accumulated charge and generate a photodetector signal (based on the accumulated charge) that can be amplified via a source follower component and ultimately read out to a column amplifier.

Abstract: A method of planning a procedure to deploy an interventional instrument comprises receiving a model of an anatomic structure. The anatomic structure includes a plurality of passageways. The method further includes identifying a target structure in the model and receiving information about an operational capability of the interventional instrument within the plurality of passageways. The method further comprises identifying a planned deployment location for positioning a distal tip of the interventional instrument to perform the procedure on the target structure based upon the operational capability of the interventional instrument.

Abstract: The present disclosure provides methods of transitioning a patient being treated for pulmonary arterial hypertension with a non-selexipag prostacyclin pathway agent (PPA) to selexipag.