Abstract: A method for simulating a technical system. Time series are obtained with the aid of a simulation model of the system, variable values being assigned to at least one epistemic parameter of the simulation model, at least one measurement series is obtained by corresponding measurements on the system, for each value of the epistemic parameter, a real-value error measure of the time series obtained for this value with respect to the measurement series and a distribution function of the error measure are calculated, and for the simulation, that value is used, for which the distribution function has the smallest distance to a Heaviside function.