Patents by Inventor Carole A. Bewley Clore

Carole A. Bewley Clore has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBACTERIAL AND ANTIFUNGAL POLYKETIDES FROM ENVIRONMENTAL AMYCOLATOPSIS SPP
    Publication number: 20230106760
    Abstract: Disclosed are compounds represented by the formula:(I), wherein R is as defined herein, and pharmaceutically acceptable salts thereof. Also disclosed are a method of treating a subject in need of treatment for a bacterial infection or a fungal infection, which includes administering to the subject an effective amount of one of the compounds or salts thereof. Further disclosed is a process for producing the compounds and salts thereof.
    Type: Application
    Filed: March 16, 2021
    Publication date: April 6, 2023
    Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
    Inventors: Carole A. Bewley Clore, Hongbing Liu, Shannon I. Ohlemacher
  • Novel peptide inhibitor of hiv fusion that disrupts the internal trimeric coiled-coil of gp41
    Publication number: 20060281673
    Abstract: This invention relates to a novel peptide inhibitor of a HIV fusion that disrupts the internal trimeric coiled-coil of gp41, to a pharmaceutical composition that comprise this inhibitor, and to methods of treating immunodeficiency disease, especially HIV, that employ such a pharmaceutical composition.
    Type: Application
    Filed: February 10, 2004
    Publication date: December 14, 2006
    Inventors: Marius Clore, Carole Bewley-Clore, John Medabalimi
  • Gp41 inhibitor
    Publication number: 20060165715
    Abstract: This invention provides a trimeric protein complex that presents an exposed N-terminal coiled-coil domain from the HIV gp41 protein. The preferred embodiment of the invention inhibits membrane fusion mediated by HIV virus. The invention also provides methods to use the trimeric protein complexes as a vaccines to prevent infection by the HIV virus.
    Type: Application
    Filed: December 17, 2002
    Publication date: July 27, 2006
    Inventors: Marius Clore, Carole Bewley-Clore, John Medabalimi