Patents by Inventor Carole L. Berger

Carole L. Berger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8313945
    Abstract: Methods are provided for inducing differentiation of blood monocytes into functional antigen presenting dendritic cells. The blood monocytes are treated by exposing the monocytes to proteins adhered to the surface of a treatment device to induce differentiation of the monocytes in to dendritic cells. Differentiation of the monocytes may also be induced by physical perturbation of the monocytes during treatment. The treated monocytes may be co-incubated with disease effector agents, which may be phagocytized by the immature dendritic cells.
    Type: Grant
    Filed: May 16, 2007
    Date of Patent: November 20, 2012
    Assignee: Yale University
    Inventors: Richard L. Edelson, Carole L. Berger
  • Publication number: 20080241815
    Abstract: Methods are provided for inducing differentiation of blood monocytes into functional antigen presenting dendritic cells. The blood monocytes are treated by exposing the monocytes to proteins adhered to the surface of a treatment device to induce differentiation of the monocytes in to dendritic cells. The treated monocytes may be co-incubated with disease effector agents which have been rendered apoptotic or other source of antigens. The apoptotic disease effector cells are phagocytized by the maturing dendritic cells. In a preferred embodiment, the blood monocytes are treated in the plastic device without use of a photoactivatable agent and light.
    Type: Application
    Filed: February 27, 2008
    Publication date: October 2, 2008
    Inventors: Richard L. Edelson, Carole L. Berger