Patents by Inventor Carole SCHWINTNER
Carole SCHWINTNER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240115623Abstract: A method of expanding a complex community of microorganisms is provided, an expanded complex community of microorganisms obtained by the method is provided, a pharmaceutical formulation comprising the expanded complex community of microorganisms is provided, and the use of the expanded complex community of microorganisms and the pharmaceutical formulation is provided.Type: ApplicationFiled: December 23, 2021Publication date: April 11, 2024Inventors: Hervé AFFAGARD, Carole SCHWINTNER, Cécile VERDIER, Sylvain DENIS, Jean-François BRUGERE, Monique ALRIC
-
Patent number: 11674751Abstract: The invention relates to a container for the lyophilisation of a liquid or semi-liquid product. The container comprises an upper portion (2) provided with a membrane which is permeable to water vapour and a lower portion (3) comprising a reservoir designed to receive the product on a bottom. The container comprises internal partitions (21) in the reservoir (19) which form a plurality of product-receiving volumes (22-27), the internal partitions (21) being configured such that introducing product into one of the predefined receiving volumes (22) causes said receiving volumes (22-27) to be successively filled in a predetermined order.Type: GrantFiled: September 24, 2019Date of Patent: June 13, 2023Assignee: MaaT PHARMAInventors: Alicia Deprez, Carole Schwintner
-
Patent number: 11389488Abstract: The present invention relates to a method for preparing a homogeneous mixture of fecal microbiota from at least two preselected donors. The homogeneous mixture of fecal microbiota thus obtained has a bacterial diversity and an increased viability. The homogeneous mixture of fecal microbiota may be used for treating intestinal dysbiosis and for treating pathologies associated with such dysbiosis.Type: GrantFiled: March 8, 2019Date of Patent: July 19, 2022Assignee: MAAT PHARMAInventors: Carole Schwintner, Alice Leroux, Clémence Mader, Hervé Affagard
-
Publication number: 20210396467Abstract: The invention relates to a container for the lyophilisation of a liquid or semi-liquid product. The container comprises an upper portion (2) provided with a membrane which is permeable to water vapour and a lower portion (3) comprising a reservoir designed to receive the product on a bottom. The container comprises internal partitions (21) in the reservoir (19) which form a plurality of product-receiving volumes (22-27), the internal partitions (21) being configured such that introducing product into one of the predefined receiving volumes (22) causes said receiving volumes (22-27) to be successively filled in a predetermined order.Type: ApplicationFiled: September 24, 2019Publication date: December 23, 2021Inventors: Alicia DEPREZ, Carole SCHWINTNER
-
Patent number: 11141440Abstract: The present invention relates to a pharmaceutical oral formulation for use in the administration of at least two bacteria derived from fecal microbiota to mammals for the treatment and/or prevention of dysbiosis and associated pathologies. The pharmaceutical oral formulation is encapsulated mixture of at least two bacteria derived from fecal microbiota wherein the capsules are coated in a pH responsive polymer composition comprising: a. 50-70% poly(methyl acrylate-co-methyl methacrylate-co-methacrylic acid) 7:3:1 by weight of dry polymer, b. 10-30% poly(methacrylic acid-co-ethyl acrylate) 1:1 by weight of dry polymer, c. at least one fatty acid mono-, di- or tri-glyceride ester, or mixtures thereof, d. at least one plasticizer, e. at least one non-ionic emulsifier. The pharmaceutical oral formulation is especially designed to be delivered principally in the ileum and colon and to maintain the sample bacterial viability and diversity.Type: GrantFiled: November 16, 2018Date of Patent: October 12, 2021Assignees: MAAT PHARMA, BIOCODEXInventors: Carole Schwintner, Marianne Robin, Jean-François Dubuisson, Hervé Affagard, Cédric Michenet, Amandine Bardy
-
Publication number: 20210310905Abstract: A sampling method using a sampling device (2) comprising a container (5) comprising a body (6) consisting of a soft pouch, and a lid (30), in which at least one among the container (5) and the lid (30) is provided with a discharging member (40) suitable for, in an open state, discharging at least one part of the gases contained in the internal space (7) of the body (6) of the container (5), wherein the sampling method comprises the steps consisting in: collecting a biological material in the body (6) of the container (5), and assembling the lid (30) on the neck (IO) of the container (5), and placing an internal space (7) of the body (6) of the container (5) under anaerobic conditions by placing the discharging member (40) in the open state, by compressing the body (6) of the container (5) and by placing the discharging member (40) in a closed state.Type: ApplicationFiled: April 27, 2021Publication date: October 7, 2021Inventors: Carole SCHWINTNER, Hervé AFFAGARD, Joël DORE
-
Publication number: 20210299188Abstract: The invention relates to the use of fecal microbiota transplant for preventing and/or reducing systemic and gut treatment-induced inflammation in an individual in need thereof.Type: ApplicationFiled: July 19, 2019Publication date: September 30, 2021Inventors: Emilie PLANTAMURA, Cyrielle GASC, Benoît LEVAST, Lilia BOUCINHA, Corentin LE CAMUS, Carole SCHWINTNER, Hervé AFFAGARD
-
Publication number: 20210154239Abstract: The present invention relates to a method for preparing a fecal 5 micro biota sample of a donor subject. Said method includes the following steps: a) collecting at least one fecal microbiota sample from the donor subject; b) within a period of less than 5 minutes after collecting the sample, placing said sample obtained in step a) in an oxygen-tight collection device; c) mixing the sample obtained in step b) with at least one aqueous saline IO solution containing at least one cryoprotectant and/or a filling agent; d) optionally, filtering the mixture obtained in step c), in particular by means of a filter comprising pores having a diameter of less than or equal to 0.7 mm, preferably less than or equal to 0.5 mm; and e) storing the mixture obtained in step c) or d) by freezing said mixture at a temperature 15 of between ?15° C. and ?100° C. Steps b) to e) are carried out in anaerobiosis.Type: ApplicationFiled: February 4, 2021Publication date: May 27, 2021Inventors: Hervé AFFAGARD, Carole SCHWiNTNER, Catherine JUSTE, Joël DORE, Patricia LEPAGE, Christei MAILLET, Sylvie RABOT, Fernanda FONSECA, Hervé BLOTTIERE
-
Patent number: 11013498Abstract: A sampling method using a sampling device (2) comprising a container (5) comprising a body (6) consisting of a soft pouch, and a lid (30), in which at least one among the container (5) and the lid (30) is provided with a discharging member (40) suitable for, in an open state, discharging at least one part of the gases contained in the internal space (7) of the body (6) of the container (5), wherein the sampling method comprises the steps consisting in: —collecting a biological material in the body (6) of the container (5), and assembling the lid (30) on the neck (10) of the container (5), —and placing an internal space (7) of the body (6) of the container (5) under anaerobic conditions by placing the discharging member (40) in the open state, by compressing the body (6) of the container (5) and by placing the discharging member (40) in a closed state.Type: GrantFiled: April 22, 2016Date of Patent: May 25, 2021Assignees: MAAT PHARMA, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUEInventors: Carole Schwintner, Hervé Affagard, Joël Dore
-
Patent number: 10980839Abstract: The present invention relates to a method for preparing a fecal 5 microbiota sample of a donor subject. Said method includes the following steps: a) collecting at least one fecal microbiota sample from the donor subject; b) within a period of less than 5 minutes after collecting the sample, placing said sample obtained in step a) in an oxygen-tight collection device; c) mixing the sample obtained in step b) with at least one aqueous saline 10 solution containing at least one cryoprotectant and/or a filling agent; d) optionally, filtering the mixture obtained in step c), in particular by means of a filter comprising pores having a diameter of less than or equal to 0.7 mm, preferably less than or equal to 0.5 mm; and e) storing the mixture obtained in step c) or d) by freezing said mixture at a temperature 15 of between ?15° C. and ?100° C. Steps b) to e) are carried out in anaerobiosis.Type: GrantFiled: April 22, 2016Date of Patent: April 20, 2021Assignees: MAAT PHARMA, INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENTInventors: Hervé Affagard, Carole Schwintner, Catherine Juste, Joël Dore, Patricia Lepage, Christel Maillet, Sylvie Rabot, Fernanda Fonseca, Hervé Blottiere
-
Publication number: 20200405776Abstract: The present invention relates to a method for preparing a homogeneous mixture of fecal microbiota from at least two preselected donors. The homogeneous mixture of fecal microbiota thus obtained has a bacterial diversity and an increased viability. The homogeneous mixture of fecal microbiota may be used for treating intestinal dysbiosis and for treating pathologies associated with such dysbiosis.Type: ApplicationFiled: March 8, 2019Publication date: December 31, 2020Inventors: Carole SCHWINTNER, Alice LEROUX, Clémence MADER, Hervé AFFAGARD
-
Publication number: 20200345790Abstract: The present invention relates to a pharmaceutical oral formulation for use in the administration of at least two bacteria derived from fecal microbiota to mammals for the treatment and/or prevention of dysbiosis and associated pathologies. The pharmaceutical oral formulation is encapsulated mixture of at least two bacteria derived from fecal microbiota wherein the capsules are coated in a pH responsive polymer composition comprising: a. 50-70% poly(methyl acrylate-co-methyl methacrylate-co-methacrylic acid) 7:3:1 by weight of dry polymer, b. 10-30% poly(methacrylic acid-co-ethyl acrylate) 1:1 by weight of dry polymer, c. at least one fatty acid mono-, di- or tri-glyceride ester, or mixtures thereof, d. at least one plasticizer, e. at least one non-ionic emulsifier. The pharmaceutical oral formulation is especially designed to be delivered principally in the ileum and colon and to maintain the sample bacterial viability and diversity.Type: ApplicationFiled: November 16, 2018Publication date: November 5, 2020Inventors: Carole SCHWINTNER, Marianne ROBIN, Jean-François DUBUISSON, Hervé AFFAGARD, Cédric MICHENET, Amandine BARDY
-
Patent number: 10736849Abstract: Method for lyophilisation of a simple of fecal microbiota. The present invention relates to a method for lyophilisation of a sample of fecal microbiota from a donor subject, comprising the following steps: A) mixing of a sample of fecal microbiota from a donor subject with a diluent selected from polyols, disaccharides to pentasaccharides, maltodextrins and mixtures thereof, and B) freezing the mixture obtained in A) at a temperature of less than ?50° C., preferably of between ?70° C. and ?100° C., followed by the lyophilisation thereof.Type: GrantFiled: December 19, 2016Date of Patent: August 11, 2020Assignees: MAAT PHARMA, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUEInventors: Hervé Affagard, Carole Schwintner, Catherine Juste, Joël Dore, Audrey Chapron, Fernanda Fonseca, Olivier David
-
Publication number: 20180369147Abstract: Method for lyophilisation of a simple of fecal microbiota. The present invention relates to a method for lyophilisation of a sample of fecal microbiota from a donor subject, comprising the following steps: A) mixing of a sample of fecal microbiota from a donor subject with a diluent selected from polyols, disaccharides to pentasaccharides, maltodextrins and mixtures thereof, and B) freezing the mixture obtained in A) at a temperature of less than ?50° C., preferably of between ?70° C. and ?100° C., followed by the lyophilisation thereof.Type: ApplicationFiled: December 19, 2016Publication date: December 27, 2018Inventors: Hervé AFFAGARD, Carole SCHWINTNER, Catherine JUSTE, Joël DORE, Audrey CHAPRON, Fernanda FONSECA, Olivier DAVID
-
Publication number: 20180116641Abstract: A sampling method using a sampling device (2) comprising a container (5) comprising a body (6) consisting of a soft pouch, and a lid (30), in which at least one among the container (5) and the lid (30) is provided with a discharging member (40) suitable for, in an open state, discharging at least one part of the gases contained in the internal space (7) of the body (6) of the container (5), wherein the sampling method comprises the steps consisting in:—collecting a biological material in the body (6) of the container (5), and assembling the lid (30) on the neck (10) of the container (5),—and placing an internal space (7) of the body (6) of the container (5) under anaerobic conditions by placing the discharging member (40) in the open state, by compressing the body (6) of the container (5) and by placing the discharging member (40) in a closed state.Type: ApplicationFiled: April 22, 2016Publication date: May 3, 2018Inventors: Carole SCHWINTNER, Hervé AFFAGARD, Joël DORE
-
Publication number: 20180099012Abstract: The present invention relates to a method for preparing a fecal 5 microbiota sample of a donor subject. Said method includes the following steps: a) collecting at least one fecal microbiota sample from the donor subject; b) within a period of less than 5 minutes after collecting the sample, placing said sample obtained in step a) in an oxygen-tight collection device; c) mixing the sample obtained in step b) with at least one aqueous saline 10 solution containing at least one cryoprotectant and/or a filling agent; d) optionally, filtering the mixture obtained in step c), in particular by means of a filter comprising pores having a diameter of less than or equal to 0.7 mm, preferably less than or equal to 0.5 mm; and e) storing the mixture obtained in step c) or d) by freezing said mixture at a temperature 15 of between ?15° C. and ?100° C. Steps b) to e) are carried out in anaerobiosis.Type: ApplicationFiled: April 22, 2016Publication date: April 12, 2018Inventors: Hervé AFFAGARD, Carole SCHWINTNER, Catherine JUSTE, Joël DORE, Patricia LEPAGE, Christel MAILLET, Sylvie RABOT, Fernanda FONSECA, Hervé BLOTTIERE