Patents by Inventor Carolin THIELE

Carolin THIELE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HYBRID CARRIERS FOR NUCLEIC ACID CARGO
    Publication number: 20230302146
    Abstract: A composition for the delivery of a nucleic acid compound is provided which comprises a cationic peptide or polymer and a lipidoid compound. The nucleic acid compound may be any chemically modified or unmodified DNA or RNA. The amount of the lipidoid in the composition is preferably low, relative to the cationic peptide or polymer.
    Type: Application
    Filed: October 20, 2022
    Publication date: September 28, 2023
    Applicant: CureVac SE
    Inventors: Patrick BAUMHOF, Carolin THIELE, Joanna REJMAN
  • Hybrid carriers for nucleic acid cargo
    Patent number: 11478552
    Abstract: A composition for the delivery of a nucleic acid compound is provided which comprises a cationic peptide or polymer and a lipidoid compound. The nucleic acid compound may be any chemically modified or unmodified DNA or RNA. The amount of the lipidoid in the composition is preferably low, relative to the cationic peptide or polymer.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: October 25, 2022
    Assignee: CureVac AG
    Inventors: Patrick Baumhof, Carolin Thiele, Joanna Rejman
  • HYBRID CARRIERS FOR NUCLEIC ACID CARGO
    Publication number: 20200179526
    Abstract: A composition for the delivery of a nucleic acid compound is provided which comprises a cationic peptide or polymer and a lipidoid compound. The nucleic acid compound may be any chemically modified or unmodified DNA or RNA. The amount of the lipidoid in the composition is preferably low, relative to the cationic peptide or polymer.
    Type: Application
    Filed: June 9, 2017
    Publication date: June 11, 2020
    Inventors: Patrick BAUMHOF, Carolin THIELE
  • HYBRID CARRIERS FOR NUCLEIC ACID CARGO
    Publication number: 20190381180
    Abstract: The invention relates to carrier compositions for nucleic acid delivery which comprise a cationic peptide or polymer in combination with a cationic lipid. The peptide or polymer comprises a disulfide linkage or an —SH moiety capable of forming a disulfide linkage. In a further aspect, the invention relates to nanoparticles comprising a complex of a bioactive cargo material with the peptide or polymer and the lipid. The invention further relates to the preparation and the uses of the nanoparticles.
    Type: Application
    Filed: June 9, 2017
    Publication date: December 19, 2019
    Inventors: Patrick BAUMHOF, Carolin THIELE
  • CATIONIC CARRIERS FOR NUCLEIC ACID DELIVERY
    Publication number: 20190336608
    Abstract: Compositions for nucleic acid delivery are provided which comprise a relatively low amount a permanently cationic lipid or lipidoid, such as a lipid comprising a quaternary ammonium group. The compositions are suitable for the delivery of chemically modified or unmodified DNA or RNA. Moreover, the compositions are suitable for local administration, such as by extravascular injection.
    Type: Application
    Filed: June 9, 2017
    Publication date: November 7, 2019
    Applicant: CureVac AG
    Inventors: Patrick BAUMHOF, Carolin THIELE
  • HYBRID CARRIERS FOR NUCLEIC ACID CARGO
    Publication number: 20190336611
    Abstract: The invention relates to carrier compositions for nucleic acid delivery which comprise a cationic peptide or polymer in combination with a cationic lipid. In a further aspect, the invention relates to nanoparticles comprising a complex of a bioactive cargo material with the peptide or polymer and the lipid. The invention further relates to the preparation and the uses of the nanoparticles.
    Type: Application
    Filed: June 9, 2017
    Publication date: November 7, 2019
    Applicant: CureVac AG
    Inventors: Patrick BAUMHOF, Carolin THIELE