Patents by Inventor Caroline A. Dobbin

Caroline A. Dobbin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chaperonin 10-induced immunomodulation
    Patent number: 9457062
    Abstract: The present invention relates to methods for modulating Toll-like receptor signalling in a subject, or in at least one cell, tissue or organ thereof, methods for treating or preventing a disease or condition in a subject, methods for modulating the production and/or secretion of one or more immunomodulators in a subject, or at least one cell, tissue or organ thereof, wherein said methods involve the administration of chaperonin 10, and wherein the chaperonin 10 associates with a Toll-like receptor in an activation cluster. Also contemplated are associated compositions and uses thereof.
    Type: Grant
    Filed: July 11, 2006
    Date of Patent: October 4, 2016
    Assignee: CBIO LIMITED
    Inventors: Barbara J. Johnson, Caroline A. Dobbin, Dean J. Naylor, Linda A. Ward, Inge E. A. Flesch, Christopher B. Howard
  • CHAPERONIN 10-INDUCED IMMUNOMODULATION
    Publication number: 20090047240
    Abstract: The present invention relates to methods for modulating Toll-like receptor signalling in a subject, or in at least one cell, tissue or organ thereof, methods for treating or preventing a disease or condition in a subject, methods for modulating the production and/or secretion of one or more immunomodulators in a subject, or at least one cell, tissue or organ thereof, wherein said methods involve the administration of chaperonin 10, and wherein the chaperonin 10 associates with a Toll-like receptor in an activation cluster. Also contemplated are associated compositions and uses thereof.
    Type: Application
    Filed: July 11, 2006
    Publication date: February 19, 2009
    Applicant: CBio LIMITED
    Inventors: Barbara J. Johnson, Caroline A. Dobbin, Dean J. Naylor, Linda A. Ward, Inge E.A. Flesch, Christopher B. Howard
  • Chaperonin 10 Modulation Of Toll-Like Receptor-Inducible Cytokine And Chemokine Secretion
    Publication number: 20070275890
    Abstract: Methods of use of Chaperonin 10 (Cpn10) are provided for regulating Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion. Cpn10 negatively regulates Toll-like receptor agonist-induced pro-inflammatory cytokine and chemokine secretion, examples being IL-6 and RANTES, respectively. Cpn10 positively regulates Toll-like receptor agonist-induced anti-inflammatory cytokine and chemokine secretion, an example being IL-10. These immunoregulatory activities of Cpn10 may be useful in the treatment of diseases, disorders and conditions resulting from excessive pro-inflammatory cytokine and chemokine secretion. This invention also relates to producing, designing and/or screening Cpn10 agonists and antagonists according to their ability to regulate Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion.
    Type: Application
    Filed: January 14, 2005
    Publication date: November 29, 2007
    Inventors: Barbara Johnson, Andreas Suhrbier, Dean Naylor, Caroline Dobbin, Christopher Howard