Patents by Inventor Caroline Besnier

Caroline Besnier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HIGH BANDWIDTH ENERGY SOURCE FOR IMPROVED TRANSMISSION THROUGH OPTICAL FIBER FOR INTRAVASCULAR LITHOTRIPSY
    Publication number: 20240189030
    Abstract: A catheter system (100) includes a light guide (122A) and a light source (124). The light guide (122A) is configured to selectively receive light energy. The light source (124) generates the light energy. The light source (124) is in optical communication with the light guide (122A). The light source can include (i) a seed source (260) that outputs the light energy, (ii) a pre-amplifier (262) that receives the light energy from the seed source (260), the pre-amplifier (262) being in optical communication with the seed source (260), and (iii) an amplifier (264) that receives the light energy from the pre-amplifier (262), the amplifier (264) being in optical communication with the pre-amplifier (262) and the light guide (122A).
    Type: Application
    Filed: February 21, 2024
    Publication date: June 13, 2024
    Inventors: Christopher A. Cook, Gerald David Bacher, Caroline Cummins, Alexandre Besnier, Patrick Maine
  • Engineering nicking endonucleases from type IIs restriction endonucleases
    Patent number: 6395523
    Abstract: The present invention relates to methods to engineer nicking endonucleases from existing Type IIs restriction endonucleases, and the production of the engineered nicking endonucleases. Two engineering methods are disclosed. One involves inactivating the dimerization function of a Type IIs restriction enzyme using site-directed mutagenesis approach. The other involves replacing the cleavage domain of a Type IIs restriction enzyme with the cleavage domain from a natural occurring nicking endonuclease, N.BstNBI.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: May 28, 2002
    Assignee: New England Biolabs, Inc.
    Inventors: Huimin Kong, Caroline Besnier, Yan Xu