Patents by Inventor Caroline Desponts

Caroline Desponts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENHANCED STEM CELL COMPOSITION
    Publication number: 20220118021
    Abstract: The invention provides improved methods for cell therapy. In particular, the invention provides therapeutic compositions of enhanced hematopoietic stem and progenitor cells having improved engraftment and homing properties, and methods of making the therapeutic compositions. The invention further provides methods of improving the efficacy of hematopoietic stem and progenitor cell transplantation including transplanting the therapeutic composition to subjects in need of hematopoietic system reconstitution.
    Type: Application
    Filed: June 4, 2021
    Publication date: April 21, 2022
    Inventors: Daniel Shoemaker, David Robbins, John D. Mendlein, Caroline Desponts
  • Enhanced stem cell composition
    Patent number: 11052118
    Abstract: The invention provides improved methods for cell therapy. In particular, the invention provides therapeutic compositions of enhanced hematopoietic stem and progenitor cells having improved engraftment and homing properties, and methods of making the therapeutic compositions. The invention further provides methods of improving the efficacy of hematopoietic stem and progenitor cell transplantation including transplanting the therapeutic composition to subjects in need of hematopoietic system reconstitution.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: July 6, 2021
    Assignee: Fate Therapeutics, Inc.
    Inventors: Daniel Shoemaker, David Robbins, John D. Mendlein, Caroline Desponts
  • HEMATOPOIETIC STEM AND PROGENITOR CELL THERAPY
    Publication number: 20200339953
    Abstract: The invention provides improved methods for cell therapy. In particular, the invention provides therapeutic compositions of modified hematopoietic stem and/or progenitor cells having improved engraftment and homing properties, and methods of making the therapeutic composition. The invention further provides methods of improving the efficacy of hematopoietic stem and progenitor cell transplantation including transplanting the therapeutic composition to subjects in need of hematopoietic system reconstitution.
    Type: Application
    Filed: May 11, 2020
    Publication date: October 29, 2020
    Inventors: Daniel Shoemaker, Pratik Multani, Caroline Desponts, David L. Robbins, Paul Grayson, John Mendlein
  • ENHANCED STEM CELL COMPOSITION
    Publication number: 20190111085
    Abstract: The invention provides improved methods for cell therapy. In particular, the invention provides therapeutic compositions of enhanced hematopoietic stem and progenitor cells having improved engraftment and homing properties, and methods of making the therapeutic compositions. The invention further provides methods of improving the efficacy of hematopoietic stem and progenitor cell transplantation including transplanting the therapeutic composition to subjects in need of hematopoietic system reconstitution.
    Type: Application
    Filed: December 12, 2018
    Publication date: April 18, 2019
    Inventors: Daniel Shoemaker, David Robbins, John D. Mendlein, Caroline Desponts
  • Enhanced stem cell composition
    Patent number: 10172888
    Abstract: The invention provides improved methods for cell therapy. In particular, the invention provides therapeutic compositions of enhanced hematopoietic stem and progenitor cells having improved engraftment and homing properties, and methods of making the therapeutic compositions. The invention further provides methods of improving the efficacy of hematopoietic stem and progenitor cell transplantation including transplanting the therapeutic composition to subjects in need of hematopoietic system reconstitution.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: January 8, 2019
    Assignee: Fate Therapeutics, Inc.
    Inventors: Daniel Shoemaker, David Robbins, John D. Mendlein, Caroline Desponts
  • COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20180171303
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: February 8, 2018
    Publication date: June 21, 2018
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • Combined chemical and genetic approaches for generation of induced pluripotent stem cells
    Patent number: 9926533
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: March 27, 2018
    Assignee: The Scripps Research Institute
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • CHEMICAL APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20180002671
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: August 23, 2017
    Publication date: January 4, 2018
    Inventors: Yan Shi, Caroline Desponts, Tongxiang Lin, Wenlin Li, Saiyong Zhu, Sheng Ding
  • Chemical approaches for generation of induced pluripotent stem cells
    Patent number: 9771563
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: September 26, 2017
    Assignee: The Scripps Research Institute
    Inventors: Yan Shi, Caroline Desponts, Tongxiang Lin, Wenlin Li, Saiyong Zhu, Sheng Ding
  • COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20170081640
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: November 30, 2016
    Publication date: March 23, 2017
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • ENHANCED STEM CELL COMPOSITION
    Publication number: 20170049820
    Abstract: The invention provides improved methods for cell therapy. In particular, the invention provides therapeutic compositions of enhanced hematopoietic stem and progenitor cells having improved engraftment and homing properties, and methods of making the therapeutic compositions. The invention further provides methods of improving the efficacy of hematopoietic stem and progenitor cell transplantation including transplanting the therapeutic composition to subjects in need of hematopoietic system reconstitution.
    Type: Application
    Filed: September 2, 2016
    Publication date: February 23, 2017
    Inventors: Daniel Shoemaker, David Robbins, John D. Mendlein, Caroline Desponts
  • Combined chemical and genetic approaches for generation of induced pluripotent stem cells
    Patent number: 9540615
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 10, 2017
    Assignee: The Scripps Research Institute
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • Combined chemical and genetic approaches for generation of induced pluripotent stem cells
    Patent number: 9534205
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Grant
    Filed: March 17, 2009
    Date of Patent: January 3, 2017
    Assignee: The Scripps Research Institute
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • CHEMICAL APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20160369244
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: June 10, 2016
    Publication date: December 22, 2016
    Inventors: Yan Shi, Caroline Desponts, Tongxiang Lin, Wenlin Li, Saiyong Zhu, Sheng Ding
  • Enhanced stem cell composition
    Patent number: 9452186
    Abstract: The invention provides improved methods for cell therapy. In particular, the invention provides therapeutic compositions of enhanced hematopoietic stem and progenitor cells having improved engraftment and homing properties, and methods of making the therapeutic compositions. The invention further provides methods of improving the efficacy of hematopoietic stem and progenitor cell transplantation including transplanting the therapeutic composition to subjects in need of hematopoietic system reconstitution.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: September 27, 2016
    Assignee: Fate Therapeutics, Inc.
    Inventors: Dan Shoemaker, David Robbins, John D. Mendlein, Caroline Desponts
  • ENHANCED STEM CELL COMPOSITION
    Publication number: 20140369972
    Abstract: The invention provides improved methods for cell therapy. In particular, the invention provides therapeutic compositions of enhanced hematopoietic stem and progenitor cells having improved engraftment and homing properties, and methods of making the therapeutic compositions. The invention further provides methods of improving the efficacy of hematopoietic stem and progenitor cell transplantation including transplanting the therapeutic composition to subjects in need of hematopoietic system reconstitution.
    Type: Application
    Filed: November 29, 2012
    Publication date: December 18, 2014
    Inventors: Dan Shoemaker, David Robbins, John D. Mendlein, Caroline Desponts
  • HEMATOPOIETIC STEM AND PROGENITOR CELL THERAPY
    Publication number: 20140030232
    Abstract: The invention provides improved methods for cell therapy. In particular, the invention provides therapeutic compositions of modified hematopoietic stem and/or progenitor cells having improved engraftment and homing properties, and methods of making the therapeutic composition. The invention further provides methods of improving the efficacy of hematopoietic stem and progenitor cell transplantation including transplanting the therapeutic composition to subjects in need of hematopoietic system reconstitution.
    Type: Application
    Filed: August 12, 2011
    Publication date: January 30, 2014
    Applicant: FATE THERAPEUTICS, INC.
    Inventors: Daniel Shoemaker, Pratik Multani, Caroline Desponts, David L. Robbins, Paul Grayson, John Mendlein
  • COMBINED CHEMICAL AND GENETIC APPROACHES FOR GENERATION OF INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20130273536
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: March 14, 2013
    Publication date: October 17, 2013
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan Zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu
  • SHIP-deficiency to increase megakaryocyte progenitor production
    Patent number: 8008273
    Abstract: The invention concerns a method for increasing megakaryocyte and megakaryocyte progenitor numbers in vitro or in vivo by suppressing SH2-containing inositol-5-phosphatase (SHIP) function in megakaryocytes or megakaryocyte progenitors expressing the SHIP gene. SHIP function can be suppressed by administering an interfering RNA, or other SHIP inhibitor, to the megakaryocytes or megakaryocyte progenitors in vitro or in vivo.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: August 30, 2011
    Assignee: University of South Florida
    Inventors: William G. Kerr, Caroline Desponts, Lia Elena Perez
  • Combined Chemical and Genetic Approaches for Generation of Induced Pluripotent Stem Cells
    Publication number: 20110110899
    Abstract: The present invention provides for identification and use of small molecules to induce pluripotency in mammalian cells as well as other methods of inducing pluripotency.
    Type: Application
    Filed: March 17, 2009
    Publication date: May 12, 2011
    Applicant: SCRIPPS RESEARCH INSTITUTE
    Inventors: Yan Shi, Caroline Desponts, Sheng Ding, Hongyan zhou, Tongxiang Lin, Wenlin Li, Saiyong Zhu