Patents by Inventor Caroline E. WELLER

Caroline E. WELLER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF TREATING A RAS PROTEIN-RELATED DISEASE OR DISORDER
    Publication number: 20260108528
    Abstract: The disclosure features methods of treating RAS protein-related disease using Compound A, or a pharmaceutically acceptable salt thereof. The disclosure also features methods of treating RAS protein-related disease including combinations including Compound A, or a pharmaceutically acceptable salt thereof, and additional therapeutic agents.
    Type: Application
    Filed: October 21, 2025
    Publication date: April 23, 2026
    Inventors: Jingjing JIANG, Lingyan JIANG, Benjamin MALDONATO, Mallika SINGH, Sophia SOHONI, Zhengping WANG, Zhican WANG, Caroline E. WELLER, Muhammad ALI
  • COMBINATION THERAPY FOR A RAS RELATED DISEASE OR DISORDER
    Publication number: 20260053798
    Abstract: The present disclosure relates to combination therapies for treating a RAS related disease or disorder (e.g., cancer). In particular, the present disclosure relates to methods of treating a RAS related disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a RAS(ON) inhibitor in combination with one or more additional therapeutic agents, pharmaceutical compositions comprising a therapeutically effective amounts of the same, kits comprising the compositions and methods of use therefor.
    Type: Application
    Filed: November 3, 2025
    Publication date: February 26, 2026
    Inventors: Ida ARONCHIK, Cristina BLAJ, Lingyan JIANG, Jingjing JIANG, Mark LABRECQUE, Bianca Jennifer LEE, Marie MENARD, Elsa QUINTANA, Kyle SEAMON, Lillian SEU, Mallika SINGH, Nataliya Tovbis SHIFRIN, Vidyasiri VEMULAPALLI, Yingyun WANG, Xing WEI, Caroline E. WELLER, David E. WILDES, Yu Chi YANG, Yongxian ZHUANG, David Church MONTGOMERY
  • Solid supports for use in solid-phase peptide synthesis, kits, and related methods
    Patent number: 10669306
    Abstract: Solid supports for use in solid-phase peptide synthesis (SPPS) are provided. The solid supports may include a resin and a protected linker coupled to the resin. The linker may be an N-mercaptoethoxyglycine, an N-mercaptopropoxyglycine, an N-mercaptobutoxyglycine, and/or another suitable linker. Kits for use in SPPS are also provided. The kits may include a solid support, a solution including a thiol or a selenol, one or more pluralities of protected amino acids, and/or a wash buffer. Methods of SPPS are also provided. The methods may include providing a solid support including a resin coupled to a protected linker.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: June 2, 2020
    Assignee: University of Washington
    Inventors: Champak Chatterjee, Patrick M. Shelton, Caroline E. Weller
  • SOLID SUPPORTS FOR USE IN SOLID-PHASE PEPTIDE SYNTHESIS, KITS, AND RELATED METHODS
    Publication number: 20190010186
    Abstract: Solid supports for use in solid-phase peptide synthesis (SPPS) are provided. The solid supports may include a resin and a protected linker coupled to the resin. The linker may be an N-mercaptoethoxyglycine, an N-mercaptopropoxyglycine, an N-mercaptobutoxyglycine, and/or another suitable linker. Kits for use in SPPS are also provided. The kits may include a solid support, a solution including a thiol or a selenol, one or more pluralities of protected amino acids, and/or a wash buffer. Methods of SPPS are also provided. The methods may include providing a solid support including a resin coupled to a protected linker.
    Type: Application
    Filed: February 3, 2017
    Publication date: January 10, 2019
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Champak CHATTERJEE, Patrick M. SHELTON, Caroline E. WELLER