Patents by Inventor Caroline HAUSER

Caroline HAUSER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Life-cycle-defective adenovirus helper viruses, their production and use for producing rAAV
    Patent number: 12123027
    Abstract: The invention generally concerns the production of defective Adenovirus helper viruses for producing a recombinant adeno-associated virus (rAAV), wherein the Adenovirus helper virus contains at least one mutation selected from (a) an inactivating mutation in the transcription unit coding for the L4-100K protein; (b) an inactivating mutation in the transcription unit coding for the L1-52/55K protein; (c) an inactivating mutation in the transcription unit coding for the preterminal protein (pTP); (d) a mutation in the L4-100K protein in order to render it temperature-sensitive (ts); (e) a mutation in the hexon protein in order to render it temperature-sensitive (ts); and/or (f) a mutation in the L4-00K protein and a mutation in the hexon protein in order to render it temperature-sensitive (ts).
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: October 22, 2024
    Assignee: Ascend Advanced Therapies Limited
    Inventors: Markus Hörer, Stefan Kochanek, Caroline Hauser, Alexandra Krüger-Haag
  • LIFE-CYCLE-DEFECTIVE ADENOVIRUS HELPER VIRUSES, THEIR PRODUCTION AND USE FOR PRODUCING RAAV
    Publication number: 20200239859
    Abstract: The invention generally concerns the production of defective Adenovirus helper viruses for producing a recombinant adeno-associated virus (rAAV), wherein the Adenovirus helper virus contains at least one mutation selected from (a) an inactivating mutation in the transcription unit coding for the L4-100K protein; (b) an inactivating mutation in the transcription unit coding for the L1-52/55K protein; (c) an inactivating mutation in the transcription unit coding for the preterminal protein (pTP); (d) a mutation in the L4-100K protein in order to render it temperature-sensitive (ts); (e) a mutation in the hexon protein in order to render it temperature-sensitive (ts); and/or (f) a mutation in the L4-00K protein and a mutation in the hexon protein in order to render it temperature-sensitive (ts).
    Type: Application
    Filed: October 12, 2018
    Publication date: July 30, 2020
    Inventors: Markus HÖRER, Stefan KOCHANEK, Caroline HAUSER, Alexandra KRÜGER-HAAG