Patents by Inventor Caroline J. Woo

Caroline J. Woo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITION AND METHODS FOR TREATMENT OF PRIMARY CILIARY DYSKINESIA
    Publication number: 20230190954
    Abstract: The present invention provides, among other things, methods and compositions for treating primary ciliary dyskinesia (PCD) based on mRNA therapy. The compositions used in treatment of PCD comprise an mRNA comprising a dynein axonemal intermediate chain 1 (DNAI1) coding sequence and are administered at an effective dose and an administration interval such that at least one symptom or feature of PCD is reduced in intensity, severity, or frequency or has a delayed onset. mRNAs with optimized DNAI1 coding sequences are provided that can be administered without the need for modifying the nucleotides of the mRNA to achieve sustained in vivo function.
    Type: Application
    Filed: May 7, 2021
    Publication date: June 22, 2023
    Inventors: Caroline J. WOO, Anusha DIAS, Khang Anh TRAN, Lianne BOEGLIN, Nicholas K. CLARK, John ANDROSAVICH, Shraddha SHARMA, Gang SUN, Neha KAUSHAL, Shrirang KARVE
  • MESSENGER RNA THERAPY FOR THE TREATMENT OF FRIEDREICH'S ATAXIA
    Publication number: 20210187122
    Abstract: The present invention provides methods and compositions of treating Friedreich's ataxia (FRDA) based on administering an mRNA encoding a frataxin protein.
    Type: Application
    Filed: September 10, 2020
    Publication date: June 24, 2021
    Inventors: Michael Heartlein, Frank DeRosa, Jonathan Cherry, Paula Lewis, Shrirang Karve, Zarna Patel, Darshan Parekh, Susan Wood, Chi-Sung Chiu, Caroline J. Woo
  • Messenger RNA therapy for the treatment of Friedreich's ataxia
    Patent number: 10780183
    Abstract: The present invention provides methods and compositions of treating Friedreich's ataxia (FRDA) based on administering an mRNA encoding a frataxin protein.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: September 22, 2020
    Assignee: TRANSLATE BIO, INC.
    Inventors: Michael Heartlein, Frank DeRosa, Jonathan Cherry, Paula Lewis, Shrirang Karve, Zarna Patel, Darshan Parekh, Susan Wood, Chi-Sung Chiu, Caroline J. Woo
  • MESSENGER RNA THERAPY FOR THE TREATMENT OF FRIEDREICH'S ATAXIA
    Publication number: 20180369413
    Abstract: The present invention provides methods and compositions of treating Friedreich's ataxia (FRDA) based on administering an mRNA encoding a frataxin protein.
    Type: Application
    Filed: June 19, 2018
    Publication date: December 27, 2018
    Inventors: Michael Heartlein, Frank DeRosa, Jonathan Cherry, Paula Lewis, Shrirang Karve, Zarna Patel, Darshan Parekh, Susan Wood, Chi-Sung Chiu, Caroline J. Woo