Patents by Inventor Caroline Jane BARELLE

Caroline Jane BARELLE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FAST-TRACK HUMANISATION OF SPECIFIC BINDING MOLECULES
    Publication number: 20240035020
    Abstract: The present invention relates to a synthetic library of vvthumanised antigen specific binding molecules derived from a member of a species in the Elasmobranchii subclass, processes for the production thereof and specific antigen specific binding molecules isolated from said library. The present invention also relates to the multi-domain specific binding molecules comprising humanised Ig-like Novel Antigen Receptor variable domains (VNARs). Specific binding domains that bind to Tumour Necrosis Factor alpha (TNF?) are also provided.
    Type: Application
    Filed: September 15, 2022
    Publication date: February 1, 2024
    Inventors: Caroline Jane BARELLE, Marina KOVALEVA, Laura Ann FERGUSON, Obinna Chukwuemeka UBAH, Andrew Justin Radcliffe PORTER
  • Synthetic library of specific binding molecules
    Patent number: 11459377
    Abstract: The present invention provides methods for the production of a library of antigen specific antigen binding molecules having a peptide domain structure represented by the following formula (I): FW 1-CDR1-FW2-HV2-FW3a-HV4-FW3b-CDR3-FW4 comprising (1) isolating RNA from a member of a species in the Elasmobranchii subclass; (2) amplifying DNA sequences from RNA obtained; (3) selecting a DNA sequence from the database prepared; (4) amplifying DNA sequences encoding two or more contiguous peptide domains of FW1-CDR1-FW2-HV2-FW3a-HV4-FW3b-CDR3-FW4; (5) ligating together said amplified DNA sequences to form DNA sequences encoding an antigen specific binding molecule; (6) cloning the amplified DNA obtained into a display vector; and (7) transforming a host with said display vector to produce a library of said antigen specific antigen binding molecules.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: October 4, 2022
    Assignee: ELASMOGEN LIMITED
    Inventors: Caroline Jane Barelle, William James Jonathan Finlay, Alfredo Darman-In-Sheeman, Andrew Justin Radcliffe Porter
  • SYNTHETIC LIBRARY OF SPECIFIC BINDING MOLECULES
    Publication number: 20200002403
    Abstract: The present invention provides methods for the production of a library of antigen specific antigen binding molecules having a peptide domain structure represented by the following formula (I): FW 1-CDR1-FW2-HV2-FW3a-HV4-FW3b-CDR3-FW4 comprising (1) isolating RNA from a member of a species in the Elasmobranchii subclass; (2) amplifying DNA sequences from RNA obtained; (3) selecting a DNA sequence from the database prepared; (4) amplifying DNA sequences encoding two or more contiguous peptide domains of FW1-CDR1-FW2-HV2-FW3a-HV4-FW3b-CDR3-FW4; (5) ligating together said amplified DNA sequences to form DNA sequences encoding an antigen specific binding molecule; (6) cloning the amplified DNA obtained into a display vector; and (7) transforming a host with said display vector to produce a library of said antigen specific antigen binding molecules.
    Type: Application
    Filed: February 11, 2019
    Publication date: January 2, 2020
    Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
    Inventors: Caroline Jane BARELLE, William James Jonathan FINLAY, Alfredo DARMAN-IN-SHEEMAN, Andrew Justin Radcliffe PORTER
  • Isolation of therapeutic target specific VNAR domains to ICOSL
    Patent number: 10472410
    Abstract: The present invention provides ICOSL specific antigen binding molecules which are isolated from immunized and synthetic Elasmobranchii derived libraries. In particular, the present invention relates to shark Variable New Antigen Receptor (VNAR) domains that specifically bind and neutralize the activity of human Induced Co-Stimulatory Ligand (ICOSL). The neutralizing VNAR domains are isolated from two independent sources; an immunized nurse shark library and a synthetic spiny dogfish framework fusion library. The molecules may be formulated as pharmaceutical compositions and used in medicine.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: November 12, 2019
    Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
    Inventors: Caroline Jane Barelle, William James Jonathan Finlay, Alfredo Darmanin-Sheehan
  • Synthetic library of specific binding molecules
    Patent number: 10202438
    Abstract: The present invention provides methods for the production of a library of antigen specific antigen binding molecules having a peptide domain structure represented by the following formula (I): FW 1-CDR1-FW2-HV2-FW3a-HV4-FW3b-CDR3-FW4 comprising (1) isolating RNA from a member of a species in the Elasmobranchii subclass; (2) amplifying DNA sequences from RNA obtained; (3) selecting a DNA sequence from the database prepared; (4) amplifying DNA sequences encoding two or more contiguous peptide domains of FW1-CDR1-FW2-HV2-FW3a-HV4-FW3b-CDR3-FW4; (5) ligating together said amplified DNA sequences to form DNA sequences encoding an antigen specific binding molecule; (6) cloning the amplified DNA obtained into a display vector; and (7) transforming a host with said display vector to produce a library of said antigen specific antigen binding molecules.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: February 12, 2019
    Assignee: THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
    Inventors: Caroline Jane Barelle, William James Jonathan Finlay, Alfredo Darman-In-Sheehan, Andrew Justin Radcliffe Porter
  • SYNTHETIC LIBRARY OF SPECIFIC BINDING MOLECULES
    Publication number: 20160176951
    Abstract: The present invention provides methods for the production of a library of antigen specific antigen binding molecules having a peptide domain structure represented by the following formula (I): FW 1-CDR1-FW2-HV2-FW3a-HV4-FW3b-CDR3-FW4 comprising (1) isolating RNA from a member of a species in the Elasmobranchii subclass; (2) amplifying DNA sequences from RNA obtained; (3) selecting a DNA sequence from the database prepared; (4) amplifying DNA sequences encoding two or more contiguous peptide domains of FW1-CDR1-FW2-HV2-FW3a-HV4-FW3b-CDR3-FW4; (5) ligating together said amplified DNA sequences to form DNA sequences encoding an antigen specific binding molecule; (6) cloning the amplified DNA obtained into a display vector; and (7) transforming a host with said display vector to produce a library of said antigen specific antigen binding molecules.
    Type: Application
    Filed: April 23, 2014
    Publication date: June 23, 2016
    Inventors: Caroline Jane BARELLE, William James Jonathan FINLAY, Alfredo DARMAN-IN-SHEEHAN, Andrew Justin Radcliffe PORTER
  • ISOLATION OF THERAPEUTIC TARGET SPECIFIC VNAR DOMAINS TO ICOSL
    Publication number: 20160068600
    Abstract: The present invention provides ICOSL specific antigen binding molecules which are isolated from immunized and synthetic Elasmobranchii derived libraries. In particular, the present invention relates to shark Variable New Antigen Receptor (VNAR) domains that specifically bind and neutralize the activity of human Induced Co-Stimulatory Ligand (ICOSL). The neutralizing VNAR domains are isolated from two independent sources; an immunized nurse shark library and a synthetic spiny dogfish framework fusion library. The molecules may be formulated as pharmaceutical compositions and used in medicine.
    Type: Application
    Filed: April 23, 2014
    Publication date: March 10, 2016
    Inventors: Caroline Jane BARELLE, William James Jonathan FINLAY, Alfredo DARMAN-IN-SHEEHAN