Abstract: The present invention relates to a culture support for cultivating hematopoietic stem cells (HSCs) and/or hematopoietic progenitors (HPs), comprising a calcium biomaterial, osteoclasts, endothelial cells and mesenchymatous stem cells (MSCs) and/or osteoblasts and/or adipocytes. The present invention also relates to a method for preparing such a culture support, and an in vitro HSC and/or HP cultivation method. The use of such a culture support for studying cellular mechanisms involved in hematopoiesis and/or differentiation of HSC/HPs and/or for studying the efficacy and/or the toxicity of a medicament candidate is also described.

Abstract: A vaccine and method of treatment suitable for treating autoimmune diseases, such as Vitiligo, by using variant peptides representing a sequence of amino acids found in heat shock protein 70. The vaccine includes a peptide derived from inducible heat shock protein 70 and a plasmid containing a full inducible heat shock protein 70 DNA sequence encoding the peptide.

Abstract: The invention relates to a non-human transgenic mammal with an IgH locus modified by replacement of the switching sequence S? with all or part of a transgene comprising the gene C? of a class A human immunoglobulin, including at least the exon, coding for the CH3 domain and the membrane exon and the applications of the above for the production of humanized class IgA antibodies.

Abstract: According to the present invention the extract of plant origin of the Globularia genus is used for a non-therapeutic cosmetic treatment of the skin and/or appendages. Preferably the species is Globularia cordifolia and the extract is obtained by in vitro plant culture. The extract can be used in particular for preventing and/or treating skin ageing by stimulating the 10 reactions of detoxification and cellular regeneration through a hormetic type response, for improving the transparency and radiance of complexion, for preventing or treating sensitive and reactive skins, for preventing or treating rednesses, for preventing protein glycation, for increasing and/or maintaining the number of dermal stem cells, for increasing and/or maintaining the dermal macromolecules, in particular collagen and elastin, for increasing the volume of the dermis, for 15 preventing and/or treating fines lines and wrinkles, for firming skin, for preventing hair loss and/or stimulating hair regrowth.

Abstract: The present invention relates to the field of cosmetic and dermopharmaceutical compositions. It concerns oligomer compounds of D-glucuronic acid or D-glucuronate with a ? (1-4) sequence (or oligoglucuronans) containing a degree of acetylation specifically between 8.7±0.5 and 9.2±0.5% by weight of O—CO—CH3 group compared to the weight of glucuronic acid and with a degree of polymerisation (DP) of 18?19±2. The oligomer compounds according to the present invention are intended to stimulate the elasticity of the dermis and epidermis although they also act to increase derma-epidermal cohesion in order to combat skin ageing, lines, wrinkles, visible and/or tactile skin discontinuities, loss of firmness, elasticity and tone and to combat skin tissue deformability. The invention also concerns a cosmetic composition containing at least one compound as recited according to the present invention.

Abstract: A non-natural HSP70 activating region that activates dendritic cells. Polypeptides that bind to the HSP70 activating region can be used to treat autoimmune diseases, such as vitiligo, by binding to HSP70 and preventing HSP70 form activating dendritic cells. The HSP70 binders can be constructed in the form of fusions proteins with a trimerizing structural element that may associate to form a trimeric complex. Pharmaceutical compositions and methods for treating vitiligo using the HSP70 binding proteins, fusion proteins and complexes.

Abstract: The invention relates to a non-human transgenic mammal with an IgH locus modified by replacement of the switching sequence S?, with all or part of a transgene comprising the gene C? of a class A human immunoglobulin, including at least the exon, coding for the CH3 domain and the membrane exon and the applications of the above for the production of humanized class IgA antibodies.

Abstract: A rotating anode is mounted on a shaft of an X-ray tube by means of a ring. The ring allows expansion and reduces the hyperstatic state of the assembly. The ring has the shape of a diabolo, preferably that of a hyperboloid structure generated by revolution. The ring dampens vibration phenomena in a shaft bearing the rotating anode and reduces noise-creating phenomena.

Abstract: An X-ray emitter and an X-ray apparatus and method of manufacturing an x-ray emitter. The emitter has an anode, a cathode, and a vacuum evacuated body in which the anode and the cathode are placed. The body has an opening and a high-voltage connector placed in the opening, the connector closing off the opening in a vacuum-tight manner, thereby subjecting the connector to a vacuum on one side of the cathode and to ambient air on an opposite side.

Abstract: A rotating anode is mounted on a shaft of an X-ray tube by means of a ring. The ring allows expansion and reduces the hyperstatic state of the assembly. The ring has the shape of a diabolo, preferably that of a hyperboloid structure generated by revolution. The ring dampens vibration phenomena in a shaft bearing the rotating anode and reduces noise-creating phenomena.

Abstract: An X-ray emitter and an X-ray apparatus and method of manufacturing an x-ray emitter. The emitter has an anode, a cathode, and a vacuum evacuated body in which the anode and the cathode are placed. The body has an opening and a high-voltage connector placed in the opening, the connector closing off the opening in a vacuum-tight manner, thereby subjecting the connector to a vacuum on one side of the cathode and to ambient air on an opposite side.

Abstract: A rotating anode is mounted on a shaft of an X-ray tube by means of a ring. The ring allows expansion and reduces the hyperstatic state of the assembly. The ring has the shape of a diabolo, preferably that of a hyperboloid structure generated by revolution. The ring dampens vibration phenomena in a shaft bearing the rotating anode and reduces noise-creating phenomena.