Patents by Inventor Caroline Reiss

Caroline Reiss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY
    Publication number: 20240131166
    Abstract: Provided herein are compositions, methods of making the same, and methods for targeted delivery of therapeutic agents for modifying expression and function of target genes, e.g. proteins involved in lipid and cholesterol metabolism such as PCSK9. Further provided herein are compositions and methods of treating conditions related to coronary disease.
    Type: Application
    Filed: September 19, 2023
    Publication date: April 25, 2024
    Inventors: Kallanthottathil G. Rajeev, Souvik Biswas, Padma Malyala, Lisa N. Kasiewicz, Alexandra Chadwick, Caroline Reiss
  • COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY
    Publication number: 20240100169
    Abstract: Provided herein are compositions, methods of making the same, and methods for targeted delivery of therapeutic agents for modifying expression and function of target genes, e.g. proteins involved in lipid and cholesterol metabolism such as PCSK9. Further provided herein are compositions and methods of treating conditions related to coronary disease.
    Type: Application
    Filed: September 19, 2023
    Publication date: March 28, 2024
    Inventors: Kallanthottathil G. Rajeev, Souvik Biswas, Padma Malyala, Lisa N. Kasiewicz, Alexandra Chadwick, Caroline Reiss
  • HYBRIDIZED GUIDE NUCLEIC ACIDS FOR USE WITH TEMPLATE-BASED GENE EDITORS
    Publication number: 20240011023
    Abstract: Polynucleotides are engineered to hybridize to one another to form a functional guide nucleic acid having an editing template. The hybridized guide nucleic acids may be used with template-based gene editors to write an edit into a target genomic location using the editing template as a template for the edit.
    Type: Application
    Filed: July 7, 2023
    Publication date: January 11, 2024
    Inventors: Vidya Subramanian, Kallanthottathil G. Rajeev, Hariharan Jayaram, Caroline Reiss, Maryam Habibian, Gitali Devi, Allison Baker
  • Compositions and methods for targeted RNA delivery
    Patent number: 11801306
    Abstract: Provided herein are compositions, methods of making the same, and methods for targeted delivery of therapeutic agents for modifying expression and function of target genes, e.g. proteins involved in lipid and cholesterol metabolism such as PCSK9. Further provided herein are compositions and methods of treating conditions related to coronary disease.
    Type: Grant
    Filed: November 23, 2021
    Date of Patent: October 31, 2023
    Assignee: Verve Therapeutics, Inc.
    Inventors: Kallanthottathil G. Rajeev, Souvik Biswas, Padma Malyala, Lisa N. Kasiewicz, Alexandra Chadwick, Caroline Reiss
  • BASE EDITING OF ANGPTL3 AND METHODS OF USING SAME FOR TREATMENT OF DISEASE
    Publication number: 20230340435
    Abstract: Provided herein are compositions for gene modification or editing and methods of using same to treat or prevent certain conditions. Specific compositions and methods capable of safely and effectively editing gene targets expressed in the liver to durably lower LDL-C thereby treating a leading cause of cardiovascular disease are disclosed.
    Type: Application
    Filed: April 9, 2021
    Publication date: October 26, 2023
    Inventors: Alexandra Chadwick, Kallanthottathil G. Rajeev, Ellen Rohde, Christopher Cheng, Caroline Reiss
  • COMPOSITIONS AND METHODS FOR CAPPING RNAS
    Publication number: 20230331763
    Abstract: Provided herein are compositions and methods for preparation of 5? end region-modified mRNAs. In particular, the instant disclosure relates to novel mRNA 5? end region motifs and sequence initiators therefore together with assays that are capable of measuring the aspects of the functionality of those motifs and sequence initiators. Further provided herein are compositions and methods of treating conditions related to coronary disease.
    Type: Application
    Filed: March 1, 2023
    Publication date: October 19, 2023
    Inventors: Christopher Cheng, Kallanthottathil Rajeev, Caroline Reiss, Kui Wang, Athul Sanjeev
  • BASE EDITING OF PCSK9 AND METHODS OF USING SAME FOR TREATMENT OF DISEASE
    Publication number: 20230159926
    Abstract: Provided herein are compositions for gene modification or editing and methods of using same to treat or prevent certain conditions. Specific compositions and methods capable of safely and effectively editing gene targets expressed in the liver to durably lower LDL-C thereby treating a leading cause of cardiovascular disease are disclosed.
    Type: Application
    Filed: April 9, 2021
    Publication date: May 25, 2023
    Inventors: Alexandra Chadwick, Kallanthottathil G. Rajeev, Ellen Rohde, Christopher Cheng, Caroline Reiss
  • CHEMICALLY MODIFIED GUIDE RNAS FOR GENOME EDITING WITH CAS9
    Publication number: 20230158174
    Abstract: Provided herein are compositions for gene modification or editing and methods of using same to treat or prevent certain conditions. Specific compositions and methods capable of safely and effectively editing gene targets expressed in the liver to durably lower LDL-C thereby treating a leading cause of cardiovascular disease are disclosed.
    Type: Application
    Filed: April 9, 2021
    Publication date: May 25, 2023
    Inventors: Alexandra Chadwick, Kallanthottathil G. Rajeev, Ellen Rohde, Christopher Cheng, Caroline Reiss
  • CHEMICALLY MODIFIED GUIDE RNAS FOR GENOME EDITING WITH CAS12B
    Publication number: 20230134582
    Abstract: Provided herein are compositions related to Cas12b guide RNAs. Also provided herein are methods for modifying target polynucleotide sequences and methods of treating or preventing a condition in a subject in need thereof, such as conditions resultant from the expression of ANGPTL3 or mutations thereto.
    Type: Application
    Filed: April 9, 2021
    Publication date: May 4, 2023
    Inventors: Kallanthottathil G. Rajeev, Alexandra Chadwick, Caroline Reiss
  • COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY
    Publication number: 20220152210
    Abstract: Provided herein are compositions, methods of making the same, and methods for targeted delivery of therapeutic agents for modifying expression and function of target genes, e.g. proteins involved in lipid and cholesterol metabolism such as PCSK9. Further provided herein are compositions and methods of treating conditions related to coronary disease.
    Type: Application
    Filed: November 23, 2021
    Publication date: May 19, 2022
    Inventors: Kallanthottathil G. Rajeev, Souvik Biswas, Padma Malyala, Lisa N. Kasiewicz, Alexandra Chadwick, Caroline Reiss
  • Compositions and methods for targeted RNA delivery
    Patent number: 11207416
    Abstract: Provided herein are compositions, methods of making the same, and methods for targeted delivery of therapeutic agents for modifying expression and function of target genes, e.g. proteins involved in lipid and cholesterol metabolism such as PCSK9. Further provided herein are compositions and methods of treating conditions related to coronary disease.
    Type: Grant
    Filed: March 4, 2021
    Date of Patent: December 28, 2021
    Assignee: Verve Therapeutics, Inc.
    Inventors: Kallanthottathil G. Rajeev, Souvik Biswas, Padma Malyala, Lisa N. Kasiewicz, Alexandra Chadwick, Caroline Reiss
  • COMPOSITIONS AND METHODS FOR TARGETED RNA DELIVERY
    Publication number: 20210299261
    Abstract: Provided herein are compositions, methods of making the same, and methods for targeted delivery of therapeutic agents for modifying expression and function of target genes, e.g. proteins involved in lipid and cholesterol metabolism such as PCSK9. Further provided herein are compositions and methods of treating conditions related to coronary disease.
    Type: Application
    Filed: March 4, 2021
    Publication date: September 30, 2021
    Inventors: Kallanthottathil G. Rajeev, Souvik Biswas, Padma Malyala, Lisa N. Kasiewicz, Alexandra Chadwick, Caroline Reiss