Abstract: Functional, brain region-specific neural spheroids comprising neuronal cells and optionally glial cells at varying ratios are disclosed, as are methods of making such spheroids and methods for their use, such as for modeling particular brain regions that may be implicated in diseases, or for observing drug effects.

Abstract: A multi-purpose balance exercise device designed to be used in multiple positions and for diverse exercises. For example, various embodiments allow for the device to be used as an aerobic step device as well as the ability to easily adjust the device to various heights to easily decrease the level of difficulty of the device for use during various exercises. The balance exercise device can provide a plurality of handles and grab points both horizontally and vertically, which allow for an enhanced number of exercises or movements using either the top and/or bottom of the device. The exercise device includes a flexible bladder filled with air, other gases, or gels attached to a substantially rigid base. The base can include an interior within which features such as handles are disposed to provide a gripping or lifting exercise for which the balance exercise device can be used.

Abstract: A exercise machine with an air filled bladder or other resilient member which provides a support surface for a user exercising thereon. The exercise machine providing many of the benefits of a traditional weight bench, while also providing the potential upside of incorporating an instability thereby engaging the user's core during exercise. A resilient member can be shaped according to the needs of the exercise to be performed. The resilient nature of the cushion limits bottoming out providing a true cushion support rather than a hard surface.

Abstract: A preacher curl exercise machine with an air filled bladder or other resilient member which provides a support surface for a user exercising thereon. The preacher curl exercise machine providing many of the benefits of a traditional weight bench, while also providing the potential upside of incorporating an instability thereby engaging the user's core during exercise. A resilient member can be shaped according to the needs of the exercise to be performed. The resilient nature of the cushion limits bottoming out providing a true cushion support rather than laying on a hard surface.