Abstract: Disclosed herein are systems, methods and compositions of matter for engineered formate dehydrogenases electrocatalytically driven in reverse to fix CO2 to formate, an electrode interface composed of self-assembled monolayers (SAM), and a nanowire link between the electrode and the enzyme's iron sulfur (FeS) cluster (engineered) to specifically link the iron sulfur cluster to the electrode. Engineering the interface between the enzyme and the electrode enables a high degree of activity and function compared to just an enzyme immobilized on the electrode. This interface enables specific orientational control of the enzyme and allows for separation of the enzyme from the electrode surface to allow retention of its native hydrodynamic radius. The transfer of electrons via the nanowire to the FeS cluster allows the enzyme to utilize its native electron transfer pathways.