Patents by Inventor Carolyn Felix

Carolyn Felix has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods for the Detection of DNA Cleavage Complexes
    Publication number: 20140357498
    Abstract: Compositions, methods, and kits for identifying protein-nucleic acid complexes, particularly DNA topoisomerase II-DNA complexes, are disclosed.
    Type: Application
    Filed: May 29, 2012
    Publication date: December 4, 2014
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Carolyn A. Felix, Brian A. Gregory, Li-San Wang, Marie L. Carrillo
  • Compositions and methods for the detection of topoisomerase II complexes with DNA
    Patent number: 8642265
    Abstract: Compositions, methods, and kits for detecting DNA topoisomerase II-DNA complexes are disclosed.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: February 4, 2014
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Carolyn A. Felix, Donald A Baldwin
  • Compositions and Methods for the Detection of Topoisomerase II Complexes with DNA
    Publication number: 20100167944
    Abstract: Compositions, methods, and kits for detecting DNA topoisomerase II-DNA complexes are disclosed.
    Type: Application
    Filed: June 19, 2009
    Publication date: July 1, 2010
    Inventors: Carolyn A. Felix, Donald A. Baldwin
  • ZEBRAFISH MODEL OF MLL LEUKEMOGENESIS
    Publication number: 20090055940
    Abstract: The zebrafish mll gene and methods of use thereof are provided.
    Type: Application
    Filed: June 18, 2007
    Publication date: February 26, 2009
    Inventors: CAROLYN A. FELIX, RITA BALICE-GORDON, GIUSEPPE GERMANO, YUAN-QUAN SONG, BLAINE W. ROBINSON
  • Compositions and methods for the detection of DNA topoisomerase II complexes with DNA
    Publication number: 20060063184
    Abstract: Compositions, methods, and kits for detecting DNA topoisomerase II-DNA complexes are disclosed.
    Type: Application
    Filed: September 9, 2005
    Publication date: March 23, 2006
    Inventors: Carolyn Felix, Donald Baldwin
  • MIFL- a new partner gene of MLL and methods of use thereof
    Publication number: 20060063179
    Abstract: Compositions and methods are provided for the identification of partner genes with MLL. Also provided is a new partner gene of MLL termed MIFL.
    Type: Application
    Filed: August 8, 2005
    Publication date: March 23, 2006
    Inventors: Carolyn Felix, Blaine Robinson, Nai-Kong Cheung
  • Methods and kits for analysis of chromosomal rearrangements associated with cancer
    Publication number: 20030096255
    Abstract: The invention relates to kits and methods for panhandle PCR amplification of a region of DNA having an unknown nucleotide sequence, wherein the region flanks a region of a cancer-associated gene having a known nucleotide sequence in a human patient. Amplification of an unknown region flanking a known region of a cancer-associated gene permits identification of a translocation partner of the gene or identification of a replicated sequence within the gene. The invention further relates to kits useful for performing the methods of the invention, to an isolated polynucleotide, and to primers derived from such an isolated polynucleotide.
    Type: Application
    Filed: April 9, 2002
    Publication date: May 22, 2003
    Inventors: Carolyn A. Felix, Douglas H. Jones, Eric Rappaport
  • Methods and kits for analysis of chromosomal rearrangements associated with leukemia
    Patent number: 6368791
    Abstract: The invention relates to kits and methods for panhandle PCR amplification of a region of DNA having an unknown nucleotide sequence, wherein the region flanks a region of a leukemia-associated gene having a known nucleotide sequence in a human patient. Amplification of an unknown region flanking a known region of a leukemia-associated gene permits identification of a translocation partner of the gene or identification of a duplicated sequence within the gene. The invention further relates to kits useful for performing the methods of the invention, to an isolated polynucleotide, and to primers derived from such an isolated polynucleotide.
    Type: Grant
    Filed: February 19, 1998
    Date of Patent: April 9, 2002
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Carolyn A. Felix, Douglas H. Jones, Eric Rappaport
  • CYP3A4 NFSE variant and methods of use therefore
    Patent number: 6174684
    Abstract: A nucleic acid sequence encoding a variant CYP3A4 gene is provided. Also provided are methods and kits for identifying individuals carrying a variant CYP3A4 gene with a heightened risk of developing or having prostate cancer or a decreased risk for developing treatment-related leukemias and identifying more effective and safer treatment regimes for individuals based upon their CYP3A4 genotype.
    Type: Grant
    Filed: August 11, 1999
    Date of Patent: January 16, 2001
    Assignees: Trustees of the University of Pennsylvania, Childrens Hospital of Pennsylvania
    Inventors: Timothy R. Rebbeck, Carolyn A. Felix