Patents by Inventor Carolyn H. Bohach

Carolyn H. Bohach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antiviral activity of Shiga toxin
    Patent number: 7135173
    Abstract: The present invention provides methods and compositions for eliminating virally-infected cells by administering a Shiga-toxin composition, and the present invention provides methods and compositions for suppressing bovine leukemia-related cell proliferation. In the methods, a Shiga-toxin composition is administered in an amount effective to suppress bovine leukemia-related cell proliferation. The Shiga-toxin composition can include a Shiga-toxin polypeptide; a probiotic microorganism expressing a Shiga-toxin polypeptide; or a transgenic plant expressing a Shiga-toxin polypeptide. In one embodiment, the Shiga-toxin polypeptide is Stx1A and, in another embodiment, the Shiga-toxin polypeptide is Stx1 holotoxin. In yet a further embodiment, the Shiga-toxin polypeptide comprises Stx2.
    Type: Grant
    Filed: December 18, 2002
    Date of Patent: November 14, 2006
    Assignee: Idaho Research Foundation, Inc.
    Inventors: Carolyn H. Bohach, Witold A. Ferens
  • Modified staphylococcal enterotoxins and expression systems therefore
    Publication number: 20040236082
    Abstract: The invention provides mutant pyrogenic toxins. Preferred mutants retain a disulfide loop structure, although the endogenous sequence of the disulfide loop may be modified for example by insertion, deletion and/or substitution of at least one amino acid residue, or by combining a pyrogenic enterotoxin (or a fragment thereof) with another polypeptide to provide a chimeric molecule. Preferred mutants have a disulfide loop having less than about 8 amino acid residues. The invention also provides a system for producing the mutant pyrogenic toxins and methods of use for the mutants.
    Type: Application
    Filed: May 18, 2004
    Publication date: November 25, 2004
    Inventors: Matthew J. Marshall, Patrick J. Shiel, Philip H. Berger, Gregory A. Bohach, Carolyn H. Bohach
  • Antiviral activity of shiga toxin
    Publication number: 20030152593
    Abstract: The present invention provides methods and compositions for eliminating virally-infected cells by administering a Shiga-toxin composition, and the present invention provides methods and compositions for suppressing bovine leukemia-related cell proliferation. In the methods, a Shiga-toxin composition is administered in an amount effective to suppress bovine leukemia-related cell proliferation. The Shiga-toxin composition can include a Shiga-toxin polypeptide; a probiotic microorganism expressing a Shiga-toxin polypeptide; or a transgenic plant expressing a Shiga-toxin polypeptide. In one embodiment, the Shiga-toxin polypeptide is Stx1A and, in another embodiment, the Shiga-toxin polypeptide is Stx1 holotoxin. In yet a further embodiment, the Shiga-toxin polypeptide comprises Stx2.
    Type: Application
    Filed: December 18, 2002
    Publication date: August 14, 2003
    Applicant: Idaho Research Foundation, Inc.
    Inventors: Carolyn H. Bohach, Witold A. Ferens
  • Methods and compositions for suppressing bovine leukemia virus with a Shiga toxin polypeptide
    Patent number: 6541013
    Abstract: The present invention provides methods and compositions for suppressing bovine leukemia-related cell proliferation. In the methods, a Shiga-toxin composition is administered in an amount effective to suppress bovine leukemia-related cell proliferation. The Shiga-toxin composition can include a Shiga-toxin polypeptide; a probiotic microorganism expressing a Shiga-toxin polypeptide; or a transgenic plant expressing a Shiga-toxin polypeptide. In one embodiment, the Shiga-toxin polypeptide is Stx1A and, in another embodiment, the Shiga-toxin polypeptide is Stx1 holotoxin.
    Type: Grant
    Filed: July 13, 2000
    Date of Patent: April 1, 2003
    Assignee: Idaho Research Foundation, Inc.
    Inventor: Carolyn H. Bohach