Patents by Inventor Carolyn M. Cover

Carolyn M. Cover has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Indole-3-carbinol (I3C) derivatives and methods
    Patent number: 6656963
    Abstract: The invention provides methods and compositions relating to novel bioactive derivatives of indole-3-carbinol (I3C), including pharmaceuticals comprising a pharmaceutically acceptable excipient and a compound of the general formula: which inhibits tumor cell growth. Methods of inhibiting targeted cell growth include contacting a target cell with a disclosed compound under conditions whereby the growth the target cell is inhibited, and methods for evaluating the growth inhibitory activity of the compounds include contacting a cell with an effective amount of the compound and measuring the CDK6 expression in the cell, wherein a reduction in CDK6 expression correlates with the growth inhibitory activity of the compound.
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: December 2, 2003
    Assignee: The Regents of the University of California
    Inventors: Gary L. Firestone, Leonard F. Bjeldanes, Carolyn M. Cover
  • Indole-3-carbinol (I3C) derivatives and methods
    Publication number: 20030087946
    Abstract: The invention provides methods and compositions relating to novel bioactive derivatives of indole-3-carbinol (I3C), including pharmaceuticals comprising a pharmaceutically acceptable excipient and a compound of the general formula: 1
    Type: Application
    Filed: April 8, 2002
    Publication date: May 8, 2003
    Applicant: The Regents of the University of California
    Inventors: Gary L. Firestone, Leonard F. Bjeldanes, Carolyn M. Cover
  • Indole-3-carbinol (13C) derivatives and methods
    Patent number: 6369095
    Abstract: The invention provides methods and compositions relating to novel bioactive derivatives of indole-3-carbinol (I3C), including pharmaceuticals comprising a pharmaceutically acceptable excipient and a compound of the general formula: which inhibits tumor cell growth. Methods of inhibiting targeted cell growth include contacting a target cell with a disclosed compound under conditions whereby the growth the target cell is inhibited, and methods for evaluating the growth inhibitory activity of the compounds include contacting a cell with an effective amount of the compound and measuring the CDK6 expression in the cell, wherein a reduction in CDK6 expression correlates with the growth inhibitory activity of the compound.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: April 9, 2002
    Assignee: The Regents of the University of California
    Inventors: Gary L. Firestone, Leonard F. Bjeldanes, Carolyn M. Cover
  • Indole-3-carbinol (I3C) derivatives and methods
    Patent number: 6150395
    Abstract: The invention provides methods and compositions relating to novel bioactive derivatives of indole-3-carbinol (I3C), including pharmaceuticals comprising a pharmaceutically acceptable excipient and a compound of the general formula: ##STR1## which inhibits tumor cell growth. Methods of inhibiting targeted cell growth include contacting a target cell with a disclosed compound under conditions whereby the growth the target cell is inhibited, and methods for evaluating the growth inhibitory activity of the compounds include contacting a cell with an effective amount of the compound and measuring the CDK6 expression in the cell, wherein a reduction in CDK6 expression correlates with the growth inhibitory activity of the compound.
    Type: Grant
    Filed: October 22, 1999
    Date of Patent: November 21, 2000
    Assignee: The Regents of the University of California
    Inventors: Gary L. Firestone, Leonard F. Bjeldanes, Carolyn M. Cover