Patents by Inventor Carolyn Mountford

Carolyn Mountford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170172495
    Abstract: The present invention relates to a method and system for using neurochemical markers to identify different types of pain, including chronic and acute, and providing the capacity to monitor response to therapy on an individual basis. The present invention relates to a method and system for using neuro biomarkers to identify pain of different types and origins, and the capacity to monitor response to therapy on a personalized basis.
    Type: Application
    Filed: March 18, 2015
    Publication date: June 22, 2017
    Inventors: Carolyn Mountford, Saadallah Ramadan, Alexander Lin
  • Patent number: 9612306
    Abstract: A method for producing a biomarker indicative of a repetitive head injury in a subject using a magnetic resonance imaging (MRI) system is provided. Two-dimensional spectroscopic data is acquired from a subject using an MRI system. From the two-dimensional spectroscopic data, a two-dimensional spectrum is produced. The two-dimensional spectrum contains spectral information indicated by a first spectral dimension and a second spectral dimension. Such a two-dimensional spectrum may include diagonal peaks and off-diagonal, or cross-peaks. In such an instance, each cross peak may indicate, for example, scalar coupling between the two protons it connects on the diagonal. However, depending on the type of method used, different types of coupling may also be present. Using the two-dimensional spectrum, a biomarker indicative of repetitive head injury in the subject is identified, and may be used to produce a report indicating a status or regression of a neurological dysfunction.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: April 4, 2017
    Assignee: Brigham and Women's Hospital, Inc.
    Inventors: Alexander Lin, Carolyn Mountford, Saadallah Ramadan, Robert Stern
  • Publication number: 20160022197
    Abstract: A method and system for detecting the presence of BRCS carriers in breast tissue, comprises obtaining spectral data from breast tissue using a magnetic resonance spectroscopy device and producing spectral data by said device which provides chemical markers to enable detection of whether the breast tissue contains BRCA carriers.
    Type: Application
    Filed: March 17, 2014
    Publication date: January 28, 2016
    Inventors: Saadallah Ramadan, Gorane Santamaria, Peter Malycha, Carolyn Mountford, David Clarke
  • Patent number: 8755862
    Abstract: A system and method identifies different components of the pain experience (nociceptive (tissue damage), neuropathic (nerve damage) and psychological) and their relative contributions by the use of magnetic resonance spectroscopy (MRS) to measure absolute and relative concentrations of metabolites in specific brain regions in the central nervous system or brain. The system and method can be used as a diagnostic tool for the assessment of the relative contribution of different aspects of the pain experience as well as monitoring of response to interventions directed at modifying these components.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: June 17, 2014
    Inventors: Phillip John Siddall, Carolyn Mountford, Anne Woodhouse, Peter Stanwell, Rajmund Somorjai
  • Patent number: 8698496
    Abstract: Methods for low-power in vivo localized multi-dimensional correlated magnetic resonance spectroscopy (“MRS”) are provided. Low-power adiabaticity is achieved, generally, using gradient-modulated radio frequency pulses for localization and mixing. The provided pulse sequences also provide a mechanism for longitudinal mixing, which significantly increases the efficiency of magnetization transfer and thereby increases signal-to-noise ratio.
    Type: Grant
    Filed: September 20, 2011
    Date of Patent: April 15, 2014
    Assignees: The General Hospital Corporation, Massachusetts Institute of Technology, The Brigham and Women's Hospital
    Inventors: Alma Gregory Sorensen, Ovidiu Cristian Andronesi, Carolyn Mountford, Saadallah Ramadan, Borjan Aleksandar Gagoski, Elfar Adalsteinsson
  • Publication number: 20140002075
    Abstract: A method for producing a biomarker indicative of a repetitive head injury in a subject using a magnetic resonance imaging (MRI) system is provided. Two-dimensional spectroscopic data is acquired from a subject using an MRI system. From the two-dimensional spectroscopic data, a two-dimensional spectrum is produced. The two-dimensional spectrum contains spectral information indicated by a first spectral dimension and a second spectral dimension. Such a two-dimensional spectrum may include diagonal peaks and off-diagonal, or cross-peaks. In such an instance, each cross peak may indicate, for example, scalar coupling between the two protons it connects on the diagonal. However, depending on the type of method used, different types of coupling may also be present. Using the two-dimensional spectrum, a biomarker indicative of repetitive head injury in the subject is identified, and may be used to produce a report indicating a status or regression of a neurological dysfunction.
    Type: Application
    Filed: November 28, 2011
    Publication date: January 2, 2014
    Inventors: Alexander Lin, Carolyn Mountford, Saadallah Ramadan, Robert Stern
  • Publication number: 20120146639
    Abstract: Methods for low-power in vivo localized multi-dimensional correlated magnetic resonance spectroscopy (“MRS”) are provided. Low-power adiabaticity is achieved, generally, using gradient-modulated radio frequency pulses for localization and mixing. The provided pulse sequences also provide a mechanism for longitudinal mixing, which significantly increases the efficiency of magnetization transfer and thereby increases signal-to-noise ratio.
    Type: Application
    Filed: September 20, 2011
    Publication date: June 14, 2012
    Inventors: Alma Gregory Sorensen, Ovidiu Cristian Andronesi, Carolyn Mountford, Saadallah Ramadan, Borjan Aleksandar Gagoski, Elfar Adalsteinsson
  • Publication number: 20100152569
    Abstract: A system and method identifies different components of the pain experience (nociceptive (tissue damage), neuropathic (nerve damage) and psychological) and their relative contributions by the use of magnetic resonance spectroscopy (MRS) to measure absolute and relative concentrations of metabolites in specific brain regions in the central nervous system or brain. The system and method can be used as a diagnostic tool for the assessment of the relative contribution of different aspects of the pain experience as well as monitoring of response to interventions directed at modifying these components.
    Type: Application
    Filed: December 22, 2009
    Publication date: June 17, 2010
    Inventors: Philip John Siddall, Carolyn Mountford, Anne Woodhouse, Peter Stanwell, Rajmund Somorjai
  • Publication number: 20050107683
    Abstract: Robust classification methods analyse magnetic resonance spectroscopy (MRS) data (spectra) of fine needle aspirates taken from breast tumours. The resultant data when compared with the histopathology and clinical criteria provide computerized classification-based diagnosis and prognosis with a very high degree of accuracy and reliability. Diagnostic correlation performed between the spectra and standard synoptic pathology findings contain detail regarding the pathology (malignant versus benign), vascular invasion by the primary cancer and lymph node involvement of the excised axillary lymph nodes. The classification strategy consisted of three stages: pre-processing of MR magnitude spectra to identify optimal spectral regions, cross-validated Linear Discriminant Analysis, and classification aggregation via Computerised Consensus Diagnosis. Malignant tissue was distinguished from benign lesions with an overall accuracy of 93%.
    Type: Application
    Filed: December 15, 2004
    Publication date: May 19, 2005
    Inventors: Carolyn Mountford, Peter Russell, Ian Smith, Rajmund Somorjai
  • Publication number: 20050020905
    Abstract: A system and method identifies different components of the pain experience (nociceptive (tissue damage), neuropathic (nerve damage) and psychological) and their relative contributions by the use of magnetic resonance spectroscopy (MRS) to measure absolute and relative concentrations of metabolites in specific brain regions in the central nervous system or brain. The system and method can be used as a diagnostic tool for the assessment of the relative contribution of different aspects of the pain experience as well as monitoring of response to interventions directed at modifying these components.
    Type: Application
    Filed: May 12, 2004
    Publication date: January 27, 2005
    Inventors: Philip Siddall, Carolyn Mountford, Anne Woodhouse, Peter Stanwell, Rajmund Somorjai