Patents by Inventor Carolyn Weeks-Levy

Carolyn Weeks-Levy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8198079
    Abstract: The present invention is directed at optimized expression vectors for the expression of native-like heterologous proteins in insect cells. Compositions of the invention are nucleotide sequences representing elements of an expression vector that when combined results in enhanced expression and secretion of heterologous proteins. The elements include sequences that define transcriptional activators, core promoters, secretion signals, and 3? untranslated regions that are functional in insect cells. The elements contained in the optimized vectors are all synthetically derived or are modified variants of naturally occurring insect sequences. The expression vectors are useful for the expression of native-like proteins when protein encoding nucleotide sequences are operatively linked to the vectors. These vectors can be used to transform insect cells, which can then be cultured to produce the desired protein product.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: June 12, 2012
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: David Edward Clements, Gordon V. L. Wang, Carolyn Weeks-Levy
  • Publication number: 20120141520
    Abstract: A West Nile virus vaccine for human use is described that preferably contains a recombinantly produced form of truncated West Nile virus envelope glycoprotein and aluminum adjuvant. The vaccine is acceptable for use in the general population, including immunosuppressed, immunocompromised, and immunosenescent individuals. The vaccine is safe and effective for use in all healthy and at-risk populations. A pharmaceutically acceptable vehicle may also be included in the vaccine.
    Type: Application
    Filed: June 1, 2010
    Publication date: June 7, 2012
    Inventors: Beth-Ann Coller, Vidya Pai, Carolyn Weeks-Levy, Steven A. Ogata
  • Publication number: 20100167389
    Abstract: The present invention is directed at optimized expression vectors for the expression of native-like heterologous proteins in insect cells. Compositions of the invention are nucleotide sequences representing elements of an expression vector that when combined results in enhanced expression and secretion of heterologous proteins. The elements include sequences that define transcriptional activators, core promoters, secretion signals, and 3? untranslated regions that are functional in insect cells. The elements contained in the optimized vectors are all synthetically derived or are modified variants of naturally occurring insect sequences. The expression vectors are useful for the expression of native-like proteins when protein encoding nucleotide sequences are operatively linked to the vectors. These vectors can be used to transform insect cells, which can then be cultured to produce the desired protein product.
    Type: Application
    Filed: April 28, 2008
    Publication date: July 1, 2010
    Applicant: Hawaii Biotech, Inc.
    Inventors: David Edward Clements, Gordon V. L. Wang, Carolyn Weeks-Levy
  • Publication number: 20080008725
    Abstract: The invention provides influenza proteins, including subunit proteins and immunogenic compositions that can be utilized, with or without adjuvants, as vaccines to protect against influenza infection in animal models and humans. The recombinant proteins are expressed from transformed insect cells that contain integrated copies of the appropriate expression cassettes in their genome. The invention uses a Drosophila melanogaster expression system to provide high yields of recombinant subunit proteins with native-like conformation.
    Type: Application
    Filed: August 16, 2006
    Publication date: January 10, 2008
    Inventors: Carolyn Weeks-Levy, David Clements, Steven Ogata
  • Publication number: 20070042001
    Abstract: The invention provides influenza proteins, including subunit proteins and immunogenic compositions that can be utilized, with or without adjuvants, as vaccines to protect against influenza infection in animal models and humans. The recombinant proteins are expressed from transformed insect cells that contain integrated copies of the appropriate expression cassettes in their genome. The invention uses a Drosophila melanogaster expression system to provide high yields of recombinant subunit proteins with native-like conformation.
    Type: Application
    Filed: August 16, 2006
    Publication date: February 22, 2007
    Inventors: Carolyn Weeks-Levy, David Clements, Steven Ogata
  • Publication number: 20070042002
    Abstract: The invention provides influenza proteins, including subunit proteins and immunogenic compositions that can be utilized, with or without adjuvants, as vaccines to protect against influenza infection in animal models and humans. The recombinant proteins are expressed from transformed insect cells that contain integrated copies of the appropriate expression cassettes in their genome. The invention uses a Drosophila melanogaster expression system to provide high yields of recombinant subunit proteins with native-like conformation.
    Type: Application
    Filed: August 16, 2006
    Publication date: February 22, 2007
    Inventors: Carolyn Weeks-Levy, David Clements, Steven Ogata
  • Patent number: 6037321
    Abstract: This invention relates to vasoactive intestinal peptide ("VIP") and cross-reactive peptides. In particular, this invention relates to peptides capable of inducing antibodies which neutralize the activity of VIP. This invention also relates to tandemly repeated peptides derived from VIP or from cross-reactive peptides, which can elicit a broad immune response. The present invention is useful for increasing egg production in bird species and for increasing efficiency of feed utilization and rate of gain in food producing animals.
    Type: Grant
    Filed: October 29, 1997
    Date of Patent: March 14, 2000
    Assignee: Biostar Inc.
    Inventors: Graham J.M. Cox, Jack Manns, Carolyn Weeks-Levy