Patents by Inventor Carrie Haskell-Luevano

Carrie Haskell-Luevano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adrenocorticotropic hormone analogs and related methods
    Patent number: 7264314
    Abstract: ACTH analog compounds of the present invention include compounds comprising an ACTH peptide sequence with one or more structural modifications that can have one or more of the following preferred ACTH analog biological functions: (1) reduction of corticosteroid secretion by adrenal membrane in the presence of the ACTH analog compared to unmodified ACTH, (2) reduction of corticosteroid secretion by adrenal membrane in the presence of endogenous ACTH and (3) increased MC-2R binding affinity with reduced activation of the MC-2R receptor compared to unmodified ACTH binding to the MC-2R melanocortin. The ACTH analog compounds of the present invention are therefore useful for treatment or prevention of diseases and disorders related to ACTH, ACTH receptors or corticosteroid secretion, such as premature labor and Cushing's Disease.
    Type: Grant
    Filed: October 27, 2005
    Date of Patent: September 4, 2007
    Inventors: Miles B. Brennan, Jessica Costa, Robert M. Dores, Ute H. Hochgeschwender, Carrie Haskell-Luevano
  • Adrenocorticotropic hormone analogs and related methods
    Publication number: 20070197774
    Abstract: ACTH analog compounds of the present invention include compounds comprising an ACTH peptide sequence with one or more structural modifications that can have one or more of the following preferred ACTH analog biological functions: (1) reduction of corticosteroid secretion by adrenal membrane in the presence of the ACTH analog compared to unmodified ACTH, (2) reduction of corticosteroid secretion by adrenal membrane in the presence of endogenous ACTH and (3) increased MC-2R binding affinity with reduced activation of the MC-2R receptor compared to unmodified ACTH binding to the MC-2R melanocortin. The ACTH analog compounds of the present invention are therefore useful for treatment or prevention of diseases and disorders related to ACTH, ACTH receptors or corticosteroid secretion, such as premature labor and Cushing's Disease.
    Type: Application
    Filed: January 19, 2007
    Publication date: August 23, 2007
    Inventors: Miles Brennan, Jessica Costa, Robert Dores, Ute Hochgeschwender, Carrie Haskell-Luevano
  • Novel melanocortin receptor templates, peptides and use thereof
    Publication number: 20060258590
    Abstract: The present invention relates to novel chimeric peptides and templates containing a combination of antagonist and agonist endogenous ligand residues. In particular, the present invention relates to novel chimeric peptides and templates thereof based upon melanocortin agonist peptides and agouti related protein (AGRP). The present invention provides multifunctional chimeric peptides having specific bioactivity at melanocortin receptors and their use as drugs to treat various diseases and conditions.
    Type: Application
    Filed: July 24, 2006
    Publication date: November 16, 2006
    Inventor: Carrie Haskell-Luevano
  • Melanocortin receptor templates, peptides, and use thereof
    Patent number: 7084111
    Abstract: The present invention relates to novel chimeric peptides and templates containing a combination of antagonist and agonist endogenous ligand residues. In particular, the present invention relates to novel chimeric peptides and templates thereof based upon melanocortin agonist peptides and agouti related protein (AGRP). The present invention provides multifunctional chimeric peptides having specific bioactivity at melanocortin receptors and their use as drugs to treat various diseases and conditions.
    Type: Grant
    Filed: June 23, 2003
    Date of Patent: August 1, 2006
    Assignee: University of Florida Research Foundation, Inc.
    Inventor: Carrie Haskell-Luevano
  • Peptides and methods for the control of obesity
    Publication number: 20060135436
    Abstract: The subject invention provides novel peptides for use in treating mammals to control appetite and obesity. Disclosed is a peptide derivative having the formula: X1-Z-Q-arg-trp-NH2 wherein: X1 is an acyl group, Z is amino-2-naphthyl-carboxylic acid or histidine, Q is (D)phenylalanine or p-iodo-(D)phenylalanine, or a pharmacologically acceptable salt, complex or derivative thereof, the peptide derivative having melanocortin-4 receptor agonist activity.
    Type: Application
    Filed: November 8, 2005
    Publication date: June 22, 2006
    Inventors: Carrie Haskell-Luevano, Jerry Holder
  • Adrenocorticotropic hormone analogs and related methods
    Publication number: 20060128620
    Abstract: ACTH analog compounds of the present invention include compounds comprising an ACTH peptide sequence with one or more structural modifications that can have one or more of the following preferred ACTH analog biological functions: (1) reduction of corticosteroid secretion by adrenal membrane in the presence of the ACTH analog compared to unmodified ACTH, (2) reduction of corticosteroid secretion by adrenal membrane in the presence of endogenous ACTH and (3) increased MC-2R binding affinity with reduced activation of the MC-2R receptor compared to unmodified ACTH binding to the MC-2R melanocortin. The ACTH analog compounds of the present invention are therefore useful for treatment or prevention of diseases and disorders related to ACTH, ACTH receptors or corticosteroid secretion, such as premature labor and Cushing's Disease.
    Type: Application
    Filed: October 27, 2005
    Publication date: June 15, 2006
    Inventors: Miles Brennan, Jessica Costa, Robert Dores, Ute Hochgeschwender, Carrie Haskell-Luevano
  • Peptides and methods for the control of obesity
    Patent number: 7034004
    Abstract: The subject invention provides novel peptides for use in treating mammals to control appetite and obesity. Disclosed is a peptide derivative having the formula: X1-Z-Q-arg-trp-NH12 wherein: X1 is an acyl group, Z is amino-2-naphthyl-carboxylic acid or histidine, Q is (D)phenylalanine or p-iodo-(D)phenylalanine, or a pharmacologically acceptable salt, complex or derivative thereof, the peptide derivative having melanocortin-4 receptor agonist activity.
    Type: Grant
    Filed: May 7, 2002
    Date of Patent: April 25, 2006
    Assignee: University of Florida
    Inventors: Carrie Haskell-Luevano, Jerry Ryan Holder
  • Novel melanocortin receptor templates, peptides, and use thereof
    Publication number: 20040260063
    Abstract: The present invention relates to novel chimeric peptides and templates containing a combination of antagonist and agonist endogenous ligand residues. In particular, the present invention relates to novel chimeric peptides and templates thereof based upon melanocortin agonist peptides and agouti related protein (AGRP). The present invention provides multifunctional chimeric peptides having specific bioactivity at melanocortin receptors and their use as drugs to treat various diseases and conditions.
    Type: Application
    Filed: June 23, 2003
    Publication date: December 23, 2004
    Inventor: Carrie Haskell-Luevano
  • Peptides and methods for the control of obesity
    Publication number: 20030212002
    Abstract: Disclosed is a peptide derivative having the formula:
    Type: Application
    Filed: May 7, 2002
    Publication date: November 13, 2003
    Applicant: University of Florida
    Inventors: Carrie Haskell-Luevano, Jerry R. Holder