Patents by Inventor Carroll Edward Ball
Carroll Edward Ball has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10639608Abstract: A system, apparatus, and method for transferring chemical solutions and synthesizing a tracer. For transferring chemical solutions, the system comprises a primary container; a secondary container; a first line in communication with the primary container and the secondary container. The first line facilitates the flow of gas and/or liquid between the primary container and the secondary container. A valve located upstream of the secondary container and downstream of the primary container regulates flow within the first line; a second line in communication with the secondary container. For synthesizing a tracer, the system includes a source of a solution having a radionuclide. A first container has a tracer precursor and is in communication with the source of solution.Type: GrantFiled: April 12, 2012Date of Patent: May 5, 2020Assignee: Siemens Medical Solutions USA, Inc.Inventors: Umesh B. Gangadharmath, Joseph C. Walsh, Hartmuth C. Kolb, Ricardo Rodriguez, Arkadij M. Elizarov, Carroll Edward Ball
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Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure
Patent number: 8435454Abstract: Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.Type: GrantFiled: January 7, 2011Date of Patent: May 7, 2013Assignee: Siemens Medical Solutions USA, Inc.Inventors: Arkadij M. Elizarov, Carroll Edward Ball, Jianzhong Zhang, Hartmuth C. Kolb, Reza Miraghaie, Todd L. Graves, Artem Lebedev, Keith E. Schleiffer -
Publication number: 20120283490Abstract: A system, apparatus, and method for transferring chemical solutions and synthesizing a tracer. For transferring chemical solutions, the system comprises a primary container; a secondary container; a first line in communication with the primary container and the secondary container. The first line facilitates the flow of gas and/or liquid between the primary container and the secondary container. A valve located upstream of the secondary container and downstream of the primary container regulates flow within the first line; a second line in communication with the secondary container. For synthesizing a tracer, the system includes a source of a solution having a radionuclide. A first container has a tracer precursor and is in communication with the source of solution.Type: ApplicationFiled: April 12, 2012Publication date: November 8, 2012Applicant: SIEMENS MEDICAL SOLUTIONS USA, INC.Inventors: Umesh B. Gangadharmath, Joseph C. Walsh, Hartmuth C. Kolb, Ricardo Rodriguez, Arkadij M. Elizarov, Carroll Edward Ball
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Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure
Patent number: 8273300Abstract: Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.Type: GrantFiled: July 8, 2010Date of Patent: September 25, 2012Assignee: Siemens Medical Solutions USA, Inc.Inventors: Arkadij M. Elizarov, Carroll Edward Ball, Jianzhong Zhang, Hartmuth C. Kolb, Reza Miraghaie, Todd Graves, Artem Lebedev -
Patent number: 8214159Abstract: Methods and apparatus to assess current aspects of Quality Control useful for release of radioactive compounds for imaging, such as PET tracers as injectables, in an automated manner, without user interference, and in compliance with regulatory guidelines. The present method and system relates to an integrated automated quality control analysis of a substance utilizing a single sample injection for a plurality of inline quality control tests. A quantitative analysis of the sample via the plurality of quality control tests is conducted. A measurement value of each of the plurality of quality control parameters is determined and a comparison of each measurement value of the plurality of quality control parameters with a predetermined corresponding criterion value is made. A cumulative quality rating for the sample is determined and the validated sample is released based on the quality rating.Type: GrantFiled: December 3, 2009Date of Patent: July 3, 2012Assignee: Siemens Medical Solutions USA, Inc.Inventors: Jianzhong Zhang, Arkadij M. Elizarov, Reza Miraghaie, Carroll Edward Ball, Hartmuth C. Kolb
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Patent number: 8173073Abstract: Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.Type: GrantFiled: October 29, 2010Date of Patent: May 8, 2012Assignee: Siemens Medical Solutions USA, Inc.Inventors: Arkadij M. Elizarov, Carroll Edward Ball, Jianzhong Zhang, Hartmuth C. Kolb, R. Michael Van Dam, Lawrence Diener, Sean Ford, Reza Miraghaie
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Patent number: 8110148Abstract: Methods and apparatus for facilitating the synthesis of compounds in a batch device are presented. Application of the batch type microfluidic devices to the synthesis of radiolabeled compounds is described. These methods and apparatus enable the selective introduction of multiple reagents via an enhanced rotary flow distribution valve through a single inlet port of the synthetic device. The sequential introduction of multiple reagents through a single inlet port allows an optimal delivery of highly concentrated reagents into the reactor and facilitates the synthesis of the desired products with a minimal loss of materials during transfers, which is critical to the synthesis of radiolabeled biomarkers.Type: GrantFiled: November 4, 2009Date of Patent: February 7, 2012Assignee: Siemens Medical Solutions USA, Inc.Inventors: Carroll Edward Ball, Arkadij M. Elizarov, Hartmuth C. Kolb, Reza Miraghaie, Jianzhong Zhang
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Patent number: 8071035Abstract: Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.Type: GrantFiled: April 14, 2008Date of Patent: December 6, 2011Assignee: Siemens Medical Solutions USA, Inc.Inventors: Arkadij M Elizarov, Carroll Edward Ball, Jianzhong Zhang, Hartmuth C. Kolb, R. Michael Van Dam, Lawrence Talcott Diener, Sean Ford, Reza Miraghaie
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Publication number: 20110202177Abstract: An apparatus and method for chemical synthesis, the method includes accessing a recipe, the recipe including a sequence of one or more processing steps for the chemical synthesis. The processing steps including one or more steps. The recipe is executed by sorting the processing steps and executing the one or more selected steps prior to executing other steps. The chemical synthesis is monitored by providing status data, indicating a status of the execution and enabling input of control data to modify execution based on the status data or user-initiated modification. Information related to the status of the execution is displayed, typically as a graphical representation of a process action.Type: ApplicationFiled: February 15, 2011Publication date: August 18, 2011Applicant: SIEMENS MEDICAL SOLUTIONS USA, INC.Inventors: Arkadij M. Elizarov, Carroll Edward Ball, Ansgar Graw, Hartmuth C. Kolb, Uttam D. Shah
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Modular System for Radiosynthesis with Multi-Run Capabilities and Reduced Risk of Radiation Exposure
Publication number: 20110150714Abstract: Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.Type: ApplicationFiled: January 7, 2011Publication date: June 23, 2011Applicant: SIEMENS MEDICAL SOLUTIONS USA, INC.Inventors: Arkadij M. Elizarov, Carroll Edward Ball, Jianzhong Zhang, Hartmuth C. Kolb, Reza Miraghaie, Todd L. Graves, Artem Lebedev, Keith E. Schleiffer -
Publication number: 20110097245Abstract: Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.Type: ApplicationFiled: October 29, 2010Publication date: April 28, 2011Applicant: SIEMENS MEDICAL SOLUTIONS USA, INC.Inventors: Arkadij M. Elizarov, Carroll Edward Ball, Jianzhong Zhang, Hartmuth C. Kolb, R. Michael Van Dam, Lawrence Diener, Sean Ford, Reza Miraghaie
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Publication number: 20110098465Abstract: Methods and apparatus for facilitating the synthesis of compounds in a nonflow-through device are presented. Application of the nonflow-through methods and microfluidic devices to the synthesis of radiolabeled compounds is described. These methods and apparatus enable the introduction of a pressurized gas through a tangential slit into a vortex reactor of the nonflow-through device, while one or more liquids are delivered to the reaction chamber through the same or different inlet ports. The introduction of the pressurized gas produces a cyclonic motion of the mixture within the reactor. Such a mechanism may be used to facilitate the evaporation of various liquids within the reactor at lower temperatures, thus reducing the production of unwanted byproducts that are associated with the use of high temperatures. In addition, thorough mixing of various liquids may be effected rapidly while allowing chemical reactions to take place efficiently within the vortex reactor.Type: ApplicationFiled: December 15, 2010Publication date: April 28, 2011Applicant: SIEMENS MEDICAL SOLUTIONS USA, INC.Inventors: Carroll Edward Ball, Arkadij M. Elizarov, Hartmuth C. Kolb
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Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure
Publication number: 20110008215Abstract: Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components.Type: ApplicationFiled: July 8, 2010Publication date: January 13, 2011Applicant: Siemens Medical Solutions USA, Inc.Inventors: Arkadij M. Elizarov, Carroll Edward Ball, Jianzhong Zhang, Hartmuth C. Kolb, Reza Miraghaie, Todd Graves, Artem Lebedev -
Patent number: 7829032Abstract: The present application relates to microfluidic devices and related technologies, and to chemical processes using such devices. More specifically, the application discloses a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner. In particular, this application describe an automated, stand-alone, microfluidic instrument for the multi-step chemical synthesis of radiopharmaceuticals, such as probes for PET and a method of using such instruments.Type: GrantFiled: January 23, 2008Date of Patent: November 9, 2010Assignee: Siemens Medical Solutions USA, Inc.Inventors: Robert Michael Van Dam, Carroll Edward Ball, Arkadij M. Elizarov, Hartmuth C. Kolb
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Publication number: 20100145630Abstract: Methods and apparatus to assess current aspects of Quality Control useful for release of radioactive compounds for imaging, such as PET tracers as injectables, in an automated manner, without user interference, and in compliance with regulatory guidelines. The present method and system relates to an integrated automated quality control analysis of a substance utilizing a single sample injection for a plurality of inline quality control tests. A quantitative analysis of the sample via the plurality of quality control tests is conducted. A measurement value of each of the plurality of quality control parameters is determined and a comparison of each measurement value of the plurality of quality control parameters with a predetermined corresponding criterion value is made. A cumulative quality rating for the sample is determined and the validated sample is released based on the quality rating.Type: ApplicationFiled: December 3, 2009Publication date: June 10, 2010Applicant: Siemens Medical Solutions USA, Inc.Inventors: Carroll Edward Ball, Arkadij M. Elizarov, Hartmuth C. Kolb, Reza Miraghaie, Jianzhong Zhang
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Publication number: 20100113762Abstract: Methods and apparatus for facilitating the synthesis of compounds in a batch device are presented. Application of the batch type microfluidic devices to the synthesis of radiolabeled compounds is described. These methods and apparatus enable the selective introduction of multiple reagents via an enhanced rotary flow distribution valve through a single inlet port of the synthetic device. The sequential introduction of multiple reagents through a single inlet port allows an optimal delivery of highly concentrated reagents into the reactor and facilitates the synthesis of the desired products with a minimal loss of materials during transfers, which is critical to the synthesis of radiolabeled biomarkers.Type: ApplicationFiled: November 4, 2009Publication date: May 6, 2010Applicant: Siemens Medical Solutions USA, Inc.Inventors: Carroll Edward Ball, Arkadij M. Elizarov, Hartmuth C. Kolb, Reza Miraghaie, Jianzhong Zhang
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Publication number: 20100093098Abstract: Methods and apparatus for facilitating the synthesis of compounds in a nonflow-through device are presented. Application of the nonflow-through methods and microfluidic devices to the synthesis of radiolabeled compounds is described. These methods and apparatus enable the introduction of a pressurized gas through a tangential slit into a vortex reactor of the nonflow-through device, while one or more liquids are delivered to the reaction chamber through the same or different inlet ports. The introduction of the pressurized gas produces a cyclonic motion of the mixture within the reactor. Such a mechanism may be used to facilitate the evaporation of various liquids within the reactor at lower temperatures, thus reducing the production of unwanted byproducts that are associated with the use of high temperatures. In addition, thorough mixing of various liquids may be effected rapidly while allowing chemical reactions to take place efficiently within the vortex reactor.Type: ApplicationFiled: October 13, 2009Publication date: April 15, 2010Applicant: Siemens Medical SolutionsInventors: Carroll Edward Ball, Arkadij Elizarov, Hartmuth C. Kolb
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Publication number: 20090036668Abstract: Methods and devices for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner are disclosed. In particular, the various embodiments of the present invention provide an automated, stand-alone, hands-free operation of the entire radiosynthesis cycle on a microfluidic device with unrestricted gas flow through the reactor, starting with target water and yielding purified PET radiotracer within a period of time shorter than conventional chemistry systems. Accordingly, one aspect of the present invention is related to a microfluidic chip for radiosynthesis of a radiolabeled compound, comprising a reaction chamber, one or more flow channels connected to the reaction chamber, one or more vents connected to said reaction chamber, and one or more integrated valves to effect flow control in and out of said reaction chamber.Type: ApplicationFiled: April 14, 2008Publication date: February 5, 2009Inventors: Arkadij M. Elizarov, Carroll Edward Ball, Jianzhong Zhang, Hartmuth Kolb, R. Michael van Dam, Lawrence Talcott Diener, Sean Ford, Reza Miraghaie
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Publication number: 20080233018Abstract: The present application relates to microfluidic devices and related technologies, and to chemical processes using such devices. More specifically, the application discloses a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in a fast, efficient and compact manner. In particular, this application describe an automated, stand-alone, microfluidic instrument for the multi-step chemical synthesis of radiopharmaceuticals, such as probes for PET and a method of using such instruments.Type: ApplicationFiled: January 23, 2008Publication date: September 25, 2008Inventors: Robert Michael van Dam, Carroll Edward Ball, Arkadij M. Elizarov, Hartmuth C. Kolb