Patents by Inventor Carroll G. Temple
Carroll G. Temple has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 5095017Abstract: 1,2-dihydropyrido[3,4-b]pyrazines are provided which possess antimitotic activity. The compounds have the structure: ##STR1## wherein R is a lower alkyl group and OR.sub.1 is a member selected from the group consisting of aryl-alkyl ethers having from seven to about 20 carbon atoms, alkyl carbamates having from one to about 12 carbon atoms, the alkyl portion of which may be substituted with a halogen atom, e.g., chlorine, fluorine, bromine or iodine; aryl-alkyl carbamates having from about seven to about 20 carbon atoms, aryl carbamates having from about six to about 20 carbon atoms, aryl-alkyl esters having from about 7 to about 20 carbon atoms, aryl esters having from about six to about 20 carbon atoms, alkylthiocarbamates having from about one to about 12 carbon atoms, aryl-alkylthiocarbamates having from about seven to about 20 carbon atoms, and arylthiocarbamates having from about six to about 20 carbon atoms.Type: GrantFiled: May 22, 1991Date of Patent: March 10, 1992Assignee: Southern Research InstituteInventor: Carroll G. Temple, Jr.
-
Patent number: 4950761Abstract: The (2S)-(-)-isomer of (5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-yl)carbamic acid, ethyl ester is significantly more potent than either the (2R)-(+)-isomer or the (R,S)-(.+-.)-racemic mixture in inhibiting mitotic cell division of L1210 leukemia cells.The compound, pharmaceutical compositions containing the compound, and a method of ameliorating cancer diseases in mammals are disclosed.Type: GrantFiled: June 2, 1989Date of Patent: August 21, 1990Assignee: Southern Research InstituteInventor: Carroll G. Temple, Jr.
-
Patent number: 4892874Abstract: It is disclosed that a compound having the formula ##STR1## or a pharmaceutically acceptable salt thereof in combination with vincristine produces synergistic antitumor activity.Type: GrantFiled: November 4, 1986Date of Patent: January 9, 1990Assignee: Southern Research InstituteInventors: Carroll G. Temple, Glynn P. Wheeler
-
Patent number: 4866059Abstract: The (2S)-(-)-isomer of (5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7-yl)arbamic acid, ethyl ester is significantly more potent than either the (2R)-(+)-isomer or the (R,S)-(.+-.)- racemic mixture in inhibiting mitotic cell division of L1210 leukemia cells.The compound, pharmaceutical compositions containing the compound, and a method of ameliorating cancer diseases in mammals are disclosed.Type: GrantFiled: April 4, 1988Date of Patent: September 12, 1989Assignee: Warner-Lambert CompanyInventor: Carroll G. Temple, Jr.
-
Patent number: 4645840Abstract: 1,2-Dihydropyrido[3,4-b]pyrazines are provided which possess anticancer activity. The compounds have the structure: ##STR1## wherein Y is CH.sub.2 or N(CH.sub.3); R.sub.1 is a lower alkyl group; e.g., an alkyl group containing up to six carbon atoms such as methyl, ethyl, propyl, butyl, etc.; R.sub.2 is a member selected from the group consisting of hydrogen, CH.sub.3 O or Cl; and R.sub.3 and R.sub.4 are either both hydrogen or one is hydrogen and the other is a lower alkyl group.Type: GrantFiled: February 3, 1986Date of Patent: February 24, 1987Assignee: Southern Research InstituteInventors: Carroll G. Temple, John A. Montgomery, Robert D. Elliott, Glynn P. Wheeler
-
Patent number: 4628089Abstract: There are disclosed novel intermediates useful in the preparation of pyrido[2,3-d]pyrimidines having the following structures: ##STR1## wherein R is CH.sub.3, CH.sub.3 CH.sub.2, CH.sub.3 CH.sub.2 CH.sub.2, CH.sub.2 .dbd.CHCH.sub.2 or CH.tbd.CCH.sub.2 ; and ##STR2## wherein R is CH.sub.3, CH.sub.3 CH.sub.2, CH.sub.3 CH.sub.2 CH.sub.2, CH.sub.2 .dbd.CHCH.sub.2 or CH.tbd.CCH.sub.2. These intermediates have the formulas: ##STR3## wherein Y is CHO, CH.sub.2 OH or CH.sub.2 Br; and Z is CH.sub.2 OH or CH.sub.2 Br.Type: GrantFiled: March 15, 1985Date of Patent: December 9, 1986Assignee: Southern Research InstituteInventors: Carroll G. Temple, John A. Montgomery, Robert D. Elliott
-
Patent number: 4600716Abstract: 1,2-Dihydropyrido[3,4-b]pyrazines are provided which possess anticancer activity. The compounds have the structure: ##STR1## wherein Y is CH.sub.2 or N(CH.sub.3); R.sub.1 is a lower alkyl group; e.g., an alkyl group containing up to six carbon atoms such as methyl, ethyl, propyl, butyl, etc.; R.sub.2 is a member selected from the group consisting of hydrogen, CH.sub.3 O or Cl; and R.sub.3 and R.sub.4 are either both hydrogen or one is hydrogen and the other is a lower alkyl group.Type: GrantFiled: March 28, 1985Date of Patent: July 15, 1986Assignee: Southern Research InstituteInventors: Carroll G. Temple, John A. Montgomery, Robert D. Elliott, Glynn P. Wheeler
-
Patent number: 4536575Abstract: There are disclosed novel intermediates useful in the preparation of pyrido[2,3-d]pyrimidines having the following structure: ##STR1## wherein R is CH.sub.3, CH.sub.3 CH.sub.2, CH.sub.3 CH.sub.2 CH.sub.2, CH.sub.2 .dbd.CHCH.sub.2 or CH.tbd.CCH.sub.2. The intermediate has the formula: ##STR2## wherein Z is CH.sub.2 OH or CH.sub.2 Br.Type: GrantFiled: November 20, 1984Date of Patent: August 20, 1985Assignee: Southern Research InstituteInventors: Carroll G. Temple, John A. Montgomery, Robert D. Elliott
-
Patent number: 4526964Abstract: There is disclosed a novel intermediate useful in the preparation of pyrido [2,3-d] pyrimidines, which includes N-[4-[(2-amino-4(3H)-oxopyrido[2,3-d]pyrimidin-6-yl)methylamino]benzoyl]-L -glutamic acid (5-deazafolic acid), N-[4-[[2-amino-4(3H)-oxopyrido[2,3-d]-pyrimidin-6-yl)methyl]methylamino]be nzoyl]-L-glutamic acid (5-deaza-N.sup.10 -methylfolic acid), N-(4-[(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methylamino]benzoyl]-L-gluta mic acid (5-deazaaminopterin), and N-[4-[[2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methyl]methylamino]benzoyl]- L-glutamic acid (5-deazamethotrexate). This intermediate is the compound 2,4-diamino-6-(hydroxymethyl)pyrido-[2,3-d]pyrimidine.Type: GrantFiled: August 31, 1982Date of Patent: July 2, 1985Assignee: Southern Research InstituteInventors: Carroll G. Temple, John A. Montgomery, Robert D. Elliott
-
Patent number: 4511721Abstract: Compounds of the formulas ##STR1## where the substituents are as defined within are disclosed as intermediates to make antifungal 1,2-Dihydropyrido[3,4-b]pyrazines.Type: GrantFiled: January 17, 1984Date of Patent: April 16, 1985Assignee: Southern Research InstituteInventors: Carroll G. Temple, Jr., John A. Montgomery, Robert D. Elliott, Glynn P. Wheeler
-
Patent number: 4451650Abstract: There are disclosed certain 2H-pyrido[4,3-b][1,4]oxazines and 2H-pyrido[4,3-b][1,4]thiazines which possess biological activity. The compounds have the structure: ##STR1## wherein n has a value of 1,2 or 3; X is oxygen or sulfur; R.sub.1 is a lower alkyl group, e.g., an alkyl group containing up to six carbon atoms such as methyl, ethyl, propyl, butyl, etc.; R.sub.2 is a member selected from the group consisting of hydrogen, alkyl radicals having from about one to about 12 carbon atoms, preferably from about one to about six carbon atoms; alkenyl radicals having from about two to about 15 carbon atoms; preferably from about two to about 10 carbon atoms; cycloalkyl radicals having from about three to about 20 carbon atoms, preferably from about three to about 15 carbon atoms; aryl, aralkyl and alkaryl radicals having from about six to about 20 carbon atoms, preferably from about six to about 15 carbon atoms; a halogen radical, e.g.Type: GrantFiled: October 26, 1982Date of Patent: May 29, 1984Assignee: Southern Research InstituteInventors: Carroll G. Temple, Jr., John A. Montgomery, Robert D. Elliott, Glynn P. Wheeler
-
Patent number: 4450160Abstract: 1,2-Dihydropyrido[3,4-b]pyrazines are provided which possess antifungal and anticancer activity. The compounds have the structure: ##STR1## wherein x has a value of 1, 2 or 3; R.sub.1 is a lower alkyl group, R.sub.2 is a member selected from the group consisting of hydrogen, alkyl radicals having from about one to about 12 carbon atoms, alkenyl radicals having from about two to about 15 carbon atoms, cycloalkyl radicals having from about three to about 20 carbon atoms, aralkyl and alkaryl radicals having from about six to about 20 carbon atoms, a halogen radical, provided that when x has a value of 1 and R.sub.2 is in the para position and R.sub.3 and R.sub.4 are both hydrogen, R.sub.Type: GrantFiled: March 3, 1982Date of Patent: May 22, 1984Assignee: Southern Research InstituteInventors: Carroll G. Temple, Jr., John A. Montgomery, Robert D. Elliott, Glynn P. Wheeler
-
Patent number: 4431805Abstract: There is disclosed a novel intermediate useful in the preparation of pyrido[2,3-d]pyrimidines, which includes N-[4- [(2-amino-4(3H)-oxopyrido[2,3-d]pyrimidin-6-yl)methylamino]benzoyl]-L-glut amic acid (5-deazafolic acid), N-[4-[[(2-amino-4(3H)-oxopyrido[2,3-d]-pyrimidin-6-yl)methyl]methylamino]b enzoyl]-L-glutamic acid (5-deaza-N.sup.10 -methylfolic acid), N-[4-[(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methylamino]benzoyl]-L-gluta mic acid (5-deazaaminopterin), and N-[4-[[(2,4-diaminopyrido[2,3-d]pyrimidin-6-yl)methyl]methylamino]benzoyl] -L-glutamic acid (5-deazamethotrexate). This intermediate is the compound 2,4-diaminopyrido[2,3-d]pyrimidine-6-carboxaldehyde.Type: GrantFiled: January 11, 1982Date of Patent: February 14, 1984Assignee: Southern Research InstituteInventors: Carroll G. Temple, John A. Montgomery, Robert D. Elliott
-
Patent number: 4206307Abstract: Improved methods for the preparation and purification of citrovorum factor are disclosed. The method includes improved procedures for hydrogenation of 10-formylfolic acid as well as for the reduction of folic acid. Also disclosed are improved procedures for opening of the imidazoline ring, and a non-chromatographic method for the purification of crude samples of citrovorum factor.Type: GrantFiled: November 7, 1978Date of Patent: June 3, 1980Assignee: United States of AmericaInventors: Carroll G. Temple, Jr., Robert D. Elliott, Jerry D. Rose, John A. Montgomery
-
Patent number: 4148999Abstract: Improved methods for the preparation and purification of citrovorum factor are disclosed. The method includes improved procedures for hydrogenation of 10-formylfolic acid as well as for the reduction of folic acid. Also disclosed are improved procedures for opening of the imidazoline ring, and a non-chromatographic method for the purification of crude samples of citrovorum factor.Type: GrantFiled: August 22, 1977Date of Patent: April 10, 1979Assignee: The Government of the United States of AmericaInventors: Carroll G. Temple, Jr., Robert D. Elliott, Jerry D. Rose, John A. Montgomery