Abstract: Provided herein are methods of determining one or more modification(s) of the nucleic acid sequence of at least one nucleic acid and at least one epigenetic alteration of the at least one nucleic acid in a sample of a subject. The sample is derived from a body fluid of the subject. The methods link the one or more modification(s) to a specific cell type.

Abstract: One or more example embodiments relates to a computer-implemented method for determining a similarity measure, the similarity measure describing a similarity between a first patient and a second patient. The method includes receiving a first patient data record, wherein the first patient data record is assigned to the first patient; receiving a second patient data record, wherein the second patient data record is assigned to the second patient; receiving or determining a medical ontology, wherein the medical ontology is independent of the first patient data record and the second patient data record; determining a patient ontology based on the medical ontology and at least one of the first patient data record or the second patient data record; and determining the similarity measure based on the patient ontology.

Abstract: A method and a device are for exchanging information regarding the clinical implications genomic variations. In an embodiment, the method includes receiving login-data of a user; evaluating the login-data received; establishing an encrypted data connection to the user after the evaluating indicates a positive evaluation of the login-data; saving, upon receiving a dataset in a context of a genomic variation, the dataset received in a memory, context-related with the genomic variation; and evaluating, upon a user request being received and connected with a search query for the genomic variation, a set of datasets from the memory, the datasets being context-related with the genomic variation and the set including the datasets that the user is authorized to receive, and sending the set of datasets to the user.

Abstract: The present invention relates to a method of selectively amplifying at least one nucleic acid sequence of at least one microorganism and/or virus in a sample of a subject, wherein k-mers 3 are applied that show a difference in frequency and/or context in the genome 2 of the at least one microorganism and/or virus compared to the genome of the subject 1.

Abstract: Disclosed are methods of predicting a radiotherapy success in a method of treating a lung cancer of a patient, the use of specific markers for predicting a radiotherapy success in a method of treating a lung cancer of a patient, a database comprising the markers, and a computer program product for use in such a method.

Abstract: The present invention relates to a method of characterizing a target DNA polynucleotide using rolling circle amplification (RCA) and a synthetic single guide RNA (sgRNA) to identify and cleave the WT version of the target DNA polynucleotide. Also provided are characterization steps based on the use of a transmembrane pore and a DNA translocase enzyme controlling the movement of the DNA polynucleotide through the transmembrane pore. Further envisaged is a kit comprising one or more oligonucleotides specific for at least a portion of the target DNA polynucleotide, an sgRNA specific for the WT version of the target DNA polynucleotide and an sgRNA-guided nucleic acid-binding protein.

Abstract: A method and a device are for exchanging information regarding the clinical implications genomic variations. In an embodiment, the method includes receiving login-data of a user; evaluating the login-data received; establishing an encrypted data connection to the user after the evaluating indicates a positive evaluation of the login-data; saving, upon receiving a dataset in a context of a genomic variation, the dataset received in a memory, context-related with the genomic variation; and evaluating, upon a user request being received and connected with a search query for the genomic variation, a set of datasets from the memory, the datasets being context-related with the genomic variation and the set including the datasets that the user is authorized to receive, and sending the set of datasets to the user.

Abstract: The present invention relates to methods of determining one or more modification(s) of the nucleic acid sequence of at least one nucleic acid and at least one epigenetic alteration of said at least one nucleic acid in a sample of a subject, wherein the sample is derived from a body fluid of the subject, in order to link the one or more modification to a specific cell type.

Abstract: The present invention relates to a method of selectively amplifying at least one nucleic acid sequence of at least one microorganism and/or virus in a sample of a subject, wherein k-mers 3 are applied that show a difference in frequency and/or context in the genome 2 of the at least one microorganism and/or virus compared to the genome of the subject 1.

Abstract: The present invention provides an improved method for correlation of session activities to a browser window in a client-server environment.

Abstract: The present invention provides an improved method for correlation of session activities to a browser window in a client-server environment.