Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: The invention relates to a housing (1), in particular for an electric drive system for a vehicle, wherein the housing (1) is configured as a system housing and is provided for receiving a plurality of system components, and wherein the housing (1) has a housing wall (11) which is produced by way of a casting mould, and a plurality of interfaces for connecting the housing (1) to components which are situated outside or inside the housing (1) are provided in or on the housing wall (11). Furthermore, the invention relates to the use of a housing (1) as a system housing for an electric drive axle of a motor vehicle.

Abstract: The present invention relates to a composition comprising (a) an alkali metal salt and/or an alkaline earth metal salt of a C4 to C10 oxocarboxylic acid and (b) an alkali metal salt and/or an alkaline earth metal salt of an unsaturated or aromatic C6 to C10 carboxylic acid, wherein (a) is present in an amount of 20 to 95 wt.-%, based on the total mass of the composition, and (b) is present in an amount of 5 to 50 wt.-%, based on the total mass of the composition, wherein the composition is present in the form of a powder, methods of its manufacture and its use for inhibiting microbial growth in cosmetic, dermatological or personal care compositions.

Abstract: The invention relates to a device (10, 10?, 10?) for holding at least two connecting cables (40), with a support element (20, 20?, 20?) in which are positioned at least two recesses (22, 22?, 22?) which, proceeding from the rim of the support element (20, 20?, 20?), exhibit an insertion area (24, 24?, 24?) adjoined by a holding area (26, 26?, 26?), in which a connecting cable (40) is in each case positioned.