Abstract: A pipetting device having a modular pipetting unit including a pipetting tip for pipetting of fluid samples and a pump conduit for transferring a negative or positive pressure to the pipetting tip is disclosed. The pipetting tip and a portion of the pump conduit adjoining the pipetting tip mutually define a fluid sample conduit for receiving the fluid samples. The modular pipetting unit is detachably attached to an automated positioning device for positioning the modular pipetting unit. A system and method for pipetting of fluid samples using such a pipetting device are also disclosed wherein pipetting of the fluid samples is performed in such a manner that each pipetted fluid sample volume is smaller than a volume of the fluid sample conduit.

Abstract: A pipetting device having a modular pipetting unit including a pipetting tip for pipetting of fluid samples and a pump conduit for transferring a negative or positive pressure to the pipetting tip is disclosed. The pipetting tip and a portion of the pump conduit adjoining the pipetting tip mutually define a fluid sample conduit for receiving the fluid samples. The modular pipetting unit is detachably attached to an automated positioning device for positioning the modular pipetting unit. A system and method for pipetting of fluid samples using such a pipetting device are also disclosed wherein pipetting of the fluid samples is performed in such a manner that each pipetted fluid sample volume is smaller than a volume of the fluid sample conduit.

Abstract: A pipetting device having a modular pipetting unit including a pipetting tip for pipetting of fluid samples and a pump conduit for transferring a negative or positive pressure to the pipetting tip is disclosed. The pipetting tip and a portion of the pump conduit adjoining the pipetting tip mutually define a fluid sample conduit for receiving the fluid samples. The modular pipetting unit is detachably attached to an automated positioning device for positioning the modular pipetting unit. A system and method for pipetting of fluid samples using such a pipetting device are also disclosed wherein pipetting of the fluid samples is performed in such a manner that each pipetted fluid sample volume is smaller than a volume of the fluid sample conduit.

Abstract: A sample preparation dosing unit for liquid dosing is provided comprising an inlet port and an outlet port fluidically coupling the sample preparation dosing unit to a supply and target, respectively; a pump, fluidically arranged between the inlet port and the outlet port; an outlet flow restrictor with an outlet flow resistance, fluidically arranged between a pump outlet and outlet port; and a control arrangement with a branch, a control valve, and a control flow restrictor with a control flow resistance. The branch divides the flow at the pump outlet into an outlet flow through the outlet flow restrictor and into a control flow through the control flow restrictor. The control flow downstream of the control flow restrictor is fed, depending on the state of the control valve, either into the outlet port thereby merging with the outlet flow downstream of the outlet flow restrictor, or into a bypass conduit.

Abstract: A sample preparation dosing unit for liquid dosing is provided comprising an inlet port and an outlet port fluidically coupling the sample preparation dosing unit to a supply and target, respectively; a pump, fluidically arranged between the inlet port and the outlet port; an outlet flow restrictor with an outlet flow resistance, fluidically arranged between a pump outlet and outlet port; and a control arrangement with a branch, a control valve, and a control flow restrictor with a control flow resistance. The branch divides the flow at the pump outlet into an outlet flow through the outlet flow restrictor and into a control flow through the control flow restrictor. The control flow downstream of the control flow restrictor is fed, depending on the state of the control valve, either into the outlet port thereby merging with the outlet flow downstream of the outlet flow restrictor, or into a bypass conduit.

Abstract: A pipetting device having a modular pipetting unit including a pipetting tip for pipetting of fluid samples and a pump conduit for transferring a negative or positive pressure to the pipetting tip is disclosed. The pipetting tip and a portion of the pump conduit adjoining the pipetting tip mutually define a fluid sample conduit for receiving the fluid samples. The modular pipetting unit is detachably attached to an automated positioning device for positioning the modular pipetting unit. A system and method for pipetting of fluid samples using such a pipetting device are also disclosed wherein pipetting of the fluid samples is performed in such a manner that each pipetted fluid sample volume is smaller than a volume of the fluid sample conduit.

Abstract: A system and method for the automated extraction of nucleic acids from nucleic acids containing samples are disclosed. In the system, reagents provided in cavities of a reagent plate are transferred to samples accommodated in a process plate using a pipetting device comprising pipettes provided with disposable pipette tips for pipetting of the reagents to obtain sample-reagent mixtures, the sample-reagent mixtures accommodated in the process plate are incubated by an incubating device to release the nucleic acids; the released nucleic acids accommodated in the process plate are separated by a separating device and released to obtain extracted nucleic acids containing fluids; the extracted nucleic acids containing fluids are transferred to cavities of an output plate by disposable pipette tips; wherein each of the samples is assigned one-to-one to a cavity of the reagent plate, at least one of the disposable pipette tips and a cavity of the output plate.

Abstract: A disposable pipette tip for releasably connecting with a pipette shaft is described, comprising an elongated flexible tubular interface having a central axis for connecting the pipette tip to the pipette shaft and an elongated tubular part extending from a distal tip opening to said tubular interface, wherein said elongated flexible tubular interface has a strain of more than of more than about 20% and wherein the extensibility of said elongated flexible tubular interface is reversible.

Abstract: Subject of the invention is an instrument for automatically processing analytical devices wherein efficient washing and hybridization is effected by moving the disposable in a controlled rotational way in heatable, open carrier manifolds.