Abstract: Many drugs and other molecules cannot ordinarily traverse the blood brain barrier (BBB). However, when alternating electric fields at certain optimum frequencies (e.g., 100 kHz) are applied to the brain, the BBB becomes permeable to those molecules. When the alternating electric fields are discontinued, the BBB eventually recovers to its original impermeable state. Subsequently, re-application of alternating electric fields at the optimum frequencies will re-open the BBB. Ordinarily, many frequencies (e.g., 200 kHz) of alternating electric fields are either ineffective or less effective at inducing permeability than the optimum frequencies. But once the BBB has been opened by applying alternating electric fields at the optimum frequencies, alternating electric fields at non-optimum frequencies can maintain the permeability of a previously-opened BBB.

Abstract: Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (e.g., 100 kHz). Once the permeability of the blood brain barrier has been increased, the substance is able to cross the blood brain barrier.

Abstract: Disclosed are methods of determining the efficacy of an alternating electric field comprising applying an alternating electric field to one or more microtumors for a period of time, the alternating electric field having a frequency and field strength, wherein the microtumor comprises primary cancer cells; and determining the efficacy of the alternating electric field. Disclosed are methods of testing the efficacy of an alternating electric field comprising applying alternating electric fields to one or more organoids for a period of time, the alternating electric fields having a frequency and field strength, wherein the organoids are cultured on organotypic hippocampal slice cultures; and determining the efficacy of alternating electric fields.

Abstract: A method allows access to computer resources to authorized native applications on a client device. An authorization server receives, from a native application on a device, an initial authorization grant, a public key of a private/public key pair generated on the device, and an attestation of authenticity of the native application. The authorization server receives, from the native application on the device, a refresh token and a digital signature of the refresh token that is created with the private key. The authorization server recognizes the refresh token only if the refresh token is verified with the public key that has been previously registered. The authorization server validates the digital signature of the refresh token, and transmits a new access token and a new refresh token to the native application on the device, thus allowing the native application on the device to access the computer resource.

Abstract: Disclosed herein is a system and method for identifying a spam email message. To identify a spam message a similarity measurement hash and a sender hash is generated for each email message. Two or more previously received email messages are compared with an incoming email message. The incoming email message is identified as a spam message when the similarity measurement hash between incoming message and one of the received messages matches and the corresponding sender hash does not match. The system may integrate with other email servers through a DNS to identify spam emails across different organizations and locations. The system and method may further apply rules to particular match to whitelist a potential spam email.

Abstract: A method allows access to computer resources to authorized native applications on a client device. An authorization server receives, from a native application on a device, an initial authorization grant, a public key of a private/public key pair generated on the device, and an attestation of authenticity of the native application. The authorization server receives, from the native application on the device, a refresh token and a digital signature of the refresh token that is created with the private key. The authorization server recognizes the refresh token only if the refresh token is verified with the public key that has been previously registered. The authorization server validates the digital signature of the refresh token, and transmits a new access token and a new refresh token to the native application on the device, thus allowing the native application on the device to access the computer resource.

Abstract: A method, computer system, and a computer program product of providing digital navigation to a user on a user device is provided. The present invention may include communicating a plurality of navigation commands to the user for navigation within a store, wherein the plurality of navigation commands are generated in response to a user-scanned QR code at the store, and are based on a user-provided specification.

Abstract: Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (e.g., 100 kHz). Once the permeability of the blood brain barrier has been increased, the substance is able to cross the blood brain barrier.

Abstract: Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (e.g., 100 kHz). Once the permeability of the blood brain barrier has been increased, the substance is able to cross the blood brain barrier.

Abstract: Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (e.g., 100 kHz). Once the permeability of the blood brain barrier has been increased, the substance is able to cross the blood brain barrier.

Abstract: Many drugs and other molecules cannot ordinarily traverse the blood brain barrier (BBB). However, when alternating electric fields at certain optimum frequencies (e.g., 100 kHz) are applied to the brain, the BBB becomes permeable to those molecules. When the alternating electric fields are discontinued, the BBB eventually recovers to its original impermeable state. Subsequently, re-application of alternating electric fields at the optimum frequencies will re-open the BBB. Ordinarily, many frequencies (e.g., 200 kHz) of alternating electric fields are either ineffective or less effective at inducing permeability than the optimum frequencies. But once the BBB has been opened by applying alternating electric fields at the optimum frequencies, alternating electric fields at non-optimum frequencies can maintain the permeability of a previously-opened BBB.

Abstract: Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (e.g., 100 kHz). Once the permeability of the blood brain barrier has been increased, the substance is able to cross the blood brain barrier.

Abstract: A method for managing quarantines. A quarantine triggered by a network access policy is detected by a computer system. A determination is made by the computer system of whether to enforce a quarantine rule for the quarantine utilizing a quarantine enforcement model trained utilizing a machine-learning process to classify quarantine rules in response to detecting the quarantine rule. The quarantine is deactivated by the computer system when the quarantine rule is classified as inappropriate such that a risk of a threat is balanced with a group of operational considerations.

Abstract: Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (e.g., 100 kHz). Once the permeability of the blood brain barrier has been increased, the substance is able to cross the blood brain barrier.

Abstract: Disclosed herein is a system and method for identifying a spam email message. To identify a spam message a similarity measurement hash and a sender hash is generated for each email message. Two or more previously received email messages are compared with an incoming email message. The incoming email message is identified as a spam message when the similarity measurement hash between incoming message and one of the received messages matches and the corresponding sender hash does not match. The system may integrate with other email servers through a DNS to identify spam emails across different organizations and locations. The system and method may further apply rules to particular match to whitelist a potential spam email.

Abstract: A method, computer system, and a computer program product of providing digital navigation to a user on a user device is provided. The present invention may include communicating a plurality of navigation commands to the user for navigation within a store, wherein the plurality of navigation commands are generated in response to a user-scanned QR code at the store, and are based on a user-provided specification.

Abstract: Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (e.g., 100 kHz). Once the permeability of the blood brain barrier has been increased, the substance is able to cross the blood brain barrier.

Abstract: Disclosed herein is a system and method for identifying a spam email message. To identify a spam message a similarity measurement hash and a sender hash is generated for each email message. Two or more previously received email messages are compared with an incoming email message. The incoming email message is identified as a spam message when the similarity measurement hash between incoming message and one of the received messages matches and the corresponding sender hash does not match. The system may integrate with other email servers through a DNS to identify spam emails across different organizations and locations. The system and method may further apply rules to particular match to whitelist a potential spam email.

Abstract: Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (e.g., 100 kHz). Once the permeability of the blood brain barrier has been increased, the substance is able to cross the blood brain barrier.

Abstract: A method for managing quarantines. A quarantine triggered by a network access policy is detected by a computer system. A determination is made by the computer system of whether to enforce a quarantine rule for the quarantine utilizing a quarantine enforcement model trained utilizing a machine-learning process to classify quarantine rules in response to detecting the quarantine rule. The quarantine is deactivated by the computer system when the quarantine rule is classified as inappropriate such that a risk of a threat is balanced with a group of operational considerations.