Abstract: In one embodiment, the present invention is a method of fusing fractures of a femoral neck using a bone plate including the steps of: placing a bone plate on the femur; inserting an assembly of a bone screw and a locking ring in an opening in the plate; simultaneously threading the locking ring and the bone screw in the femur; threading the bone screw in the femur to compress the fracture; creating a space between the locking ring and the bone screw; and allowing the bone screw to move towards the locking ring when the femur is loaded. In another embodiment, the present invention is a bone plating system including a bone plate having a plurality of openings; at least one bone screw capable of being received through the opening and into a bone; at least one end cap fixedly insertable in the opening; and a layer of polymeric material interposed between the end cap and the top of the head.

Abstract: In one embodiment, the present invention is a method of fusing fractures of a femoral neck using a bone plate including the steps of: placing a bone plate on the femur; inserting an assembly of a bone screw and a locking ring in an opening in the plate; simultaneously threading the locking ring and the bone screw in the femur; threading the bone screw in the femur to compress the fracture; creating a space between the locking ring and the bone screw; and allowing the bone screw to move towards the locking ring when the femur is loaded. In another embodiment, the present invention is a bone plating system including a bone plate having a plurality of openings; at least one bone screw capable of being received through the opening and into a bone; at least one end cap fixedly insertable in the opening; and a layer of polymeric material interposed between the end cap and the top of the head.

Abstract: A bone plate having a plurality of openings for receiving a compression bone screw or a cortical screw. An end cap, threadably insertable in the opening and having a layer of polymeric material interposed between the end cap and the top of the head such that the compression of the polymeric material would allow slight axial movement of the screw. Alternatively, a locking ring adapted to attach to the head of the screw and having shape complimentary to the features formed on the head. The locking ring and the bone screw being assembled together and being insertable in the bone simultaneously using a dedicated instrument. Compression may be applied to a bone fracture by turning the bone screw alone after the locking ring has reached its final axial position.

Abstract: A hip fracture device providing distance limited dynamization, load controlled dynamization and combinations of both dynamization methods by varying components. The hip fracture device includes a plate having a head portion and a shaft portion. A barrel projects from the head portion of the plate and a screw is inserted in the barrel. A friction pin is slidably connected with the screw, and an end cap is fixed to the head portion of the plate. The friction pin is fixedly connected with the end cap. The screw slides over the friction pin and toward the end cap when a load is applied on the fracture device. The load required for further sliding of the screw over the friction pin increases incrementally as the screw slides towards the end cap.

Abstract: The present invention relates to recombinant seven-transmembrane receptor, whereby the amino terminus of said recombinant receptor is located on an extracellular side and the carboxy-terminus is located on an intracellular side of a membrane, comprising at least two detectable labels, whereby a first of said at least two detectable labels is or is located on the carboxy-terminus and whereby a second of said at least two labels is or is located on the first or third intracellular loop or whereby a first of said at least two labels is or is located on the third intracellular loop. Furthermore, nucleic acid molecules encoding said recombinant seven-transmembrane receptors are described as well as vector and host cells comprising the same. Furthermore, the present invention provides for identification and screening methods for molecules or compounds which are capable of modifying the biological end of pharmacological function of seven-transmembrane receptor proteins.

Abstract: A bone plate having a plurality of openings for receiving a compression bone screw or a cortical screw. An end cap, threadably insertable in the opening and having a layer of polymeric material interposed between the end cap and the top of the head such that the compression of the polymeric material would allow slight axial movement of the screw. Alternatively, a locking ring adapted to attach to the head of the screw and having shape complimentary to the features formed on the head. The locking ring and the bone screw being assembled together and being insertable in the bone simultaneously using a dedicated instrument. Compression may be applied to a bone fracture by turning the bone screw alone after the locking ring has reached its final axial position.

Abstract: A hip fracture device providing distance limited dynamization, load controlled dynamization and combinations of both dynamization methods by varying components. The hip fracture device includes a plate having a head portion and a shaft portion. A barrel projects from the head portion of the plate and a screw is inserted in the barrel. A friction pin is slidably connected with the screw, and an end cap is fixed to the head portion of the plate. The friction pin is fixedly connected with the end cap. The screw slides over the friction pin and toward the end cap when a load is applied on the fracture device. The load required for further sliding of the screw over the friction pin increases incrementally as the screw slides towards the end cap.