Patents by Inventor Carsten I. Rosenow

Carsten I. Rosenow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Choline binding proteins for anti-pneumococcal vaccines
    Patent number: 7425327
    Abstract: The invention relates to bacterial choline binding proteins (CBPs) which bind choline. Such proteins are particularly desirable for vaccines against appropriate strains of Gram positive bacteria, particularly streptococcus, and more particularly pneumococcus. Also provided are DNA sequences encoding the bacterial choline binding proteins or fragment thereof, antibodies to the bacterial choline binding proteins, pharmaceutical compositions comprising the bacterial choline binding proteins, antibodies to the bacterial choline binding proteins suitable for use in passive immunization, and small molecule inhibitors of choline binding protein mediated adhesion. Methods for diagnosing the presence of the bacterial choline binding protein, or of the bacteria, are also provided. In a specific embodiment, a streptococcal choline binding protein is an enolase, which demonstrates strong affinity for fibronectin.
    Type: Grant
    Filed: July 28, 2004
    Date of Patent: September 16, 2008
    Assignee: The Rockefeller University
    Inventors: H. Robert Masure, Carsten I. Rosenow, Elaine Tuomanen, Theresa M. Wizemann
  • Choline binding proteins for anti-pneumococcal vaccines
    Patent number: 6784164
    Abstract: The invention relates to bacterial choline binding proteins (CBPs) which bind choline. Such proteins are particularly desirable for vaccines against appropriate strains of Gram positive bacteria, particularly streptococcus, and more particularly pneumococcus. Also provided are DNA sequences encoding the bacterial choline binding proteins or fragment thereof, antibodies to the bacterial choline binding proteins, pharmaceutical compositions comprising the bacterial choline binding proteins, antibodies to the bacterial choline binding proteins suitable for use in passive immunization, and small molecule inhibitors of choline binding protein mediated adhesion. Methods for diagnosing the presence of the bacterial choline binding protein, or of the bacteria, are also provided. In a specific embodiment, a streptococcal choline binding protein is an enolase, which demonstrates strong affinity for fibronectin.
    Type: Grant
    Filed: April 9, 2001
    Date of Patent: August 31, 2004
    Assignee: The Rockefeller University
    Inventors: H. Robert Masure, Carsten I. Rosenow, Elaine Tuomanen, Theresa M. Wizemann
  • Choline binding proteins for anti-pneumococcal vaccines
    Publication number: 20030175293
    Abstract: The invention relates to bacterial choline binding proteins (CBPs) which bind choline. Such proteins are particularly desirable for vaccines against appropriate strains of Gram positive bacteria, particularly streptococcus, and more particularly pneumococcus. Also provided are DNA sequences encoding the bacterial choline binding proteins or fragment thereof, antibodies to the bacterial choline binding proteins, pharmaceutical compositions comprising the bacterial choline binding proteins, antibodies to the bacterial choline binding proteins suitable for use in passive immunization, and small molecule inhibitors of choline binding protein mediated adhesion. Methods for diagnosing the presence of the bacterial choline binding protein, or of the bacteria, are also provided. In a specific embodiment, a streptococcal choline binding protein is an enolase, which demonstrates strong affinity for fibronectin.
    Type: Application
    Filed: April 9, 2001
    Publication date: September 18, 2003
    Inventors: H. Robert Masure, Carsten I. Rosenow, Elaine Tuomanen, Theresa M. Wizemann
  • Choline binding proteins for anti-pneumococcal vaccines
    Patent number: 6245335
    Abstract: The invention relates to bacterial choline binding proteins (CBPs) which bind choline. Such proteins are particularly desirable for vaccines against appropriate strains of Gram positive bacteria, particularly streptococcus, and more particularly pneumococcus. Also provided are DNA sequences encoding the bacterial choline binding proteins or fragment thereof, antibodies to the bacterial choline binding proteins, pharmaceutical compositions comprising the bacterial choline binding proteins, antibodies to the bacterial choline binding proteins suitable for use in passive immunization, and small molecule inhibitors of choline binding protein mediated adhesion. Methods for diagnosing the presence of the bacterial choline binding protein, or of the bacteria, are also provided. In a specific embodiment, a streptococcal choline binding protein is an enolase, which demonstrates strong affinity for fibronectin.
    Type: Grant
    Filed: May 1, 1997
    Date of Patent: June 12, 2001
    Assignee: The Rockefeller University
    Inventors: H. Robert Masure, Carsten I. Rosenow, Elaine Tuomanen, Theresa M. Wizemann