Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: The invention relates to a process for the production of at least two-layer thermoplastic sheets via thermal welding of at least one thinner thermoplastic sheet with density (D1) and of at least one second thinner thermoplastic sheet with density (D2), where the density (D1) of the first thinner thermoplastic sheet is smaller than the density (D2) of the second thinner thermoplastic sheet. The process introduces at least one first heating element and at least one second heating element along mutually offset planes between the two thinner thermoplastic sheets, where the surfaces of the thinner thermoplastic sheets do not touch the surfaces of the heating elements. The first heating element transfers a quantity of energy (E1) to the surface of the first thinner thermoplastic sheet, and the second heating element transfers a quantity of energy (E2) to the surface of the second thinner thermoplastic sheet, where the quantity of energy (E1) is smaller than the quantity of energy (E2).

Abstract: The present invention relates to a process for the production of at least two-layer thermoplastic foam sheets via thermal welding of at least two thinner thermoplastic foam sheets. In the process of the invention, at least two heating elements are conducted on mutually offset planes between the surfaces to be welded of the thinner thermoplastic foam sheets, and the foam sheets here do not touch the heating elements. The number of layers of the thermoplastic foam sheet is per se a result of the number of thinner thermoplastic foam sheets that are thermally welded to one another. If by way of example three thinner thermoplastic foam sheets are thermally welded to one another, a three-layer thermoplastic foam sheet is per se obtained, and if there are four thinner thermoplastic foam sheets the result is accordingly per se a four-layer thermoplastic foam sheet.

Abstract: The invention relates to a process for the production of at least two-layer thermoplastic sheets via thermal welding of at least one thinner thermoplastic sheet with density (D1) and of at least one second thinner thermoplastic sheet with density (D2), where the density (D1) of the first thinner thermoplastic sheet is smaller than the density (D2) of the second thinner thermoplastic sheet. The process introduces at least one first heating element and at least one second heating element along mutually offset planes between the two thinner thermoplastic sheets, where the surfaces of the thinner thermoplastic sheets do not touch the surfaces of the heating elements. The first heating element transfers a quantity of energy (E1) to the surface of the first thinner thermoplastic sheet, and the second heating element transfers a quantity of energy (E2) to the surface of the second thinner thermoplastic sheet, where the quantity of energy (E1) is smaller than the quantity of energy (E2).

Abstract: The present invention relates to a process for the production of at least two-layer thermoplastic foam sheets via thermal welding of at least two thinner thermoplastic foam sheets. In the process of the invention, at least two heating elements are conducted on mutually offset planes between the surfaces to be welded of the thinner thermoplastic foam sheets, and the foam sheets here do not touch the heating elements. The number of layers of the thermoplastic foam sheet is per se a result of the number of thinner thermoplastic foam sheets that are thermally welded to one another. If by way of example three thinner thermoplastic foam sheets are thermally welded to one another, a three-layer thermoplastic foam sheet is per se obtained, and if there are four thinner thermoplastic foam sheets the result is accordingly per se a four-layer thermoplastic foam sheet.

Abstract: A process for the production of an at least two-layer thermoplastic foam sheet via symmetrical bonding, e.g., by thermal welding, of at least two thinner thermoplastic foam sheets to give the at least two-layer thermoplastic foam sheet. The invention further relates to thermoplastic foam sheets having at least two layers. The number of the layers of the thermoplastic foam sheet derives from the number of thin thermoplastic foam sheets that are thermally welded to one another.