Patents by Inventor Carsten Schelp

Carsten Schelp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9720004
    Abstract: Methods and reagents are disclosed for conducting assays. Embodiments of the present methods and reagents are concerned with chemiluminescent reagents for determining the presence and/or amount of an analyte in a sample suspected of containing the analyte. The reagent is non-particulate and comprises a binding partner for the analyte and a chemiluminescent composition comprising an olefinic compound and a metal chelate. In embodiments of an assay, a combination is provided that comprises a sample suspected of containing the analyte, a chemiluminescent reagent as described above and a sensitizer reagent capable of generating singlet oxygen. The combination is subjected to conditions for binding of the analyte to the binding partner for the analyte. The sensitizer is activated and the amount of luminescence generated by the chemiluminescent composition is detected wherein the amount of luminescence is related to the amount of the analyte in the sample.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: August 1, 2017
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Pratap Singh, Yi Feng Zheng, Liping Geng, Roland Janzen, Carsten Schelp
  • Publication number: 20160231336
    Abstract: Methods and reagents are disclosed for conducting assays. Embodiments of the present methods and reagents are concerned with chemiluminescent reagents for determining the presence and/or amount of an analyte in a sample suspected of containing the analyte. The reagent is non-particulate and comprises a binding partner for the analyte and a chemiluminescent composition comprising an olefinic compound and a metal chelate. In embodiments of an assay, a combination is provided that comprises a sample suspected of containing the analyte, a chemiluminescent reagent as described above and a sensitizer reagent capable of generating singlet oxygen. The combination is subjected to conditions for binding of the analyte to the binding partner for the analyte. The sensitizer is activated and the amount of luminescence generated by the chemiluminescent composition is detected wherein the amount of luminescence is related to the amount of the analyte in the sample.
    Type: Application
    Filed: April 18, 2016
    Publication date: August 11, 2016
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventors: Pratap Singh, Yi Feng Zheng, Liping Geng, Roland Janzen, Carsten Schelp
  • Patent number: 9347947
    Abstract: Methods and reagents are disclosed for conducting assays. Embodiments of the present methods and reagents are concerned with chemiluminescent reagents for determining the presence and/or amount of an analyte in a sample suspected of containing the analyte. The reagent is non-particulate and comprises a binding partner for the analyte and a chemiluminescent composition comprising an olefinic compound and a metal chelate. In embodiments of an assay, a combination is provided that comprises a sample suspected of containing the analyte, a chemiluminescent reagent as described above and a sensitizer reagent capable of generating singlet oxygen. The combination is subjected to conditions for binding of the analyte to the binding partner for the analyte. The sensitizer is activated and the amount of luminescence generated by the chemiluminescent composition is detected wherein the amount of luminescence is related to the amount of the analyte in the sample.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: May 24, 2016
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Pratap Singh, Yi Feng Zheng, Liping Geng, Roland Janzen, Carsten Schelp
  • Patent number: 8628933
    Abstract: The invention relates to a kit for a homogenous detection method for the quantitative or qualitative detection of an analyte in an assay and adequate reagents therefor, particularly a homogenous binding test. According to the invention, an analyte-specific binding partner R1 comprises more than one specific binding point for a specific binding partner X that is associated with a component of a signal-forming system while a second analyte-specific binding partner R2 comprises more than one specific binding point for a specific binding partner Y which is also associated with a component of a signal-forming system.
    Type: Grant
    Filed: January 23, 2013
    Date of Patent: January 14, 2014
    Assignee: Siemens Healthcare Diagnostics Products GmbH
    Inventors: Carsten Schelp, Michael Trier, Hrair Kirakossian
  • Patent number: 8399209
    Abstract: The invention relates to methods for the quantitative or qualitative detection of an analyte in an assay and adequate reagents therefor, particularly a homogeneous binding test. According to the invention, an analyte-specific binding partner R1 comprises more than one specific binding point for a specific binding partner X that is associated with a component of a signal-forming system while a second analyte-specific binding partner R2 comprises more than one specific binding point for a specific binding partner Y which is also associated with a component of a signal-forming system.
    Type: Grant
    Filed: May 31, 2006
    Date of Patent: March 19, 2013
    Assignee: Siemens Healthcare Diagnostics Products GmbH
    Inventors: Carsten Schelp, Michael Trier, Hrair Kirakossian
  • Patent number: 8304205
    Abstract: The invention relates to methods for determining the activity of a proteolytic coagulation factor of the blood coagulation cascade in a body fluid such as whole blood or plasma. A combination is provided in a reaction mixture. The combination comprises the sample and an activation agent for activating a proteolytic coagulation factor of the blood coagulation cascade or for activating the blood coagulation cascade. The effect of the activating on a reagent system comprising a cleavable moiety is evaluated. The cleavable moiety is or becomes bound to a chemiluminescent agent or a sensitizer agent or both. The chemiluminescent agent and the sensitizer agent are related in that, when in close proximity, energization of the sensitizer agent results in energization of the chemiluminescent agent. The effect of the activating is related to the activity of a proteolytic coagulation factor of the blood coagulation cascade wherein the effect is the extent of cleavage of the cleavable moiety.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: November 6, 2012
    Assignee: Siemens Healthcare Diagnostics Products GmbH
    Inventors: Andreas Kappel, Andrea Lichte, Norbert Zander, Stefan Teigelkamp, Sabine Teigelkamp, legal representative, Carsten Schelp
  • Patent number: 8153442
    Abstract: Methods and reagents are disclosed for conducting assays. Embodiments of the present methods and reagents are concerned with a solid support such as, for example, a particle. The support includes a chemiluminescent composition that includes a metal chelate. The present inventors observed that, when such support such as, e.g., particles, were employed in assays for the determination of an analyte, stability of signal output by the chemiluminescent composition associated with the particle was unacceptably reduced as compared to particles including other chemiluminescent compositions. In accordance with embodiments of the present invention, the stability of signal output from such particles is enhanced by including in a medium that contains the particles a sufficient amount of one or more stabilizing agents, which may be a chelating agent and/or a metal chelate such as, for example, the metal chelate that is associated with the particle.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: April 10, 2012
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Alan R. Craig, Zhu Teng, Carsten Schelp, Jason Snyder, Christine Moran
  • Publication number: 20110091978
    Abstract: Methods and reagents are disclosed for conducting assays. Embodiments of the present methods and reagents are concerned with a solid support such as, for example, a particle. The support comprises a chemiluminescent composition that comprises a metal chelate. The present inventors observed that, when such support such as, e.g., particles, were employed in assays for the determination of an analyte, stability of signal output by the chemiluminescent composition associated with the particle was unacceptably reduced as compared to particles comprising other chemiluminescent compositions. In accordance with embodiments of the present invention, the stability of signal output from such particles is enhanced by including in a medium comprising the particles a sufficient amount of one or more stabilizing agents, which may be a chelating agent and/or a metal chelate such as, for example, the metal chelate that is associated with the particle.
    Type: Application
    Filed: October 21, 2009
    Publication date: April 21, 2011
    Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.
    Inventors: Alan R. Craig, Zhu Teng, Carsten Schelp, Jason Snyder, Christine Moran
  • Patent number: 7867781
    Abstract: The invention relates to a method for quantitatively or qualitatively detecting an analyte in a sample, with the sample being incubated, for the purpose of avoiding, diminishing and/or detecting the high-dose hook effect, with an analyte-specific binding partner R1, which is associated with a solid phase, an analyte-specific binding partner R2, which is associated with a label L1, and an analyte-specific binding partner R3, which is associated with a label L2, and the L1-dependent measurement signal being determined either at a different time from the L2-dependent or L1 plus L2-dependent measurement signal or using a different measurement method.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: January 11, 2011
    Assignee: Siemens Healthcare Diagnostics Products GmbH
    Inventors: Carsten Schelp, Hans-Erwin Pauly
  • Publication number: 20100311185
    Abstract: The invention relates to a method for quantitatively or qualitatively detecting an analyte in a sample, with the sample being incubated, for the purpose of avoiding, diminishing and/or detecting the high-dose hook effect, with an analyte-specific binding partner R1, which is associated with a solid phase, an analyte-specific binding partner R2, which is associated with a label L1, and an analyte-specific binding partner R3, which is associated with a label L2, and the L1-dependent measurement signal being determined either at a different time from the L2-dependent or L1 plus L2-dependent measurement signal or using a different measurement method.
    Type: Application
    Filed: December 21, 2001
    Publication date: December 9, 2010
    Inventors: Carsten Schelp, Hans-Erwin Pauly
  • Publication number: 20100248218
    Abstract: The invention relates to methods for the quantitative and qualitative detection of an analyte in an assay as well as appropriate reagents therefor, especially a carrier molecule to which one or several analyte-specific binding partners are bound and which is provided with additional binding points for a specific binding partner X or Y that is associated with a component of a signal-forming system. Also disclosed is the use of such a conjugate particularly in homogeneous binding tests.
    Type: Application
    Filed: May 31, 2006
    Publication date: September 30, 2010
    Inventors: Carsten Schelp, Pratap Singh, Michael Trier, Harald Ackermann, Susan C. Swann, Lee Hall
  • Publication number: 20100233725
    Abstract: Methods and reagents are disclosed for conducting assays. Embodiments of the present methods and reagents are concerned with chemiluminescent reagents for determining the presence and/or amount of an analyte in a sample suspected of containing the analyte. The reagent is non-particulate and comprises a binding partner for the analyte and a chemiluminescent composition comprising an olefinic compound and a metal chelate. In embodiments of an assay, a combination is provided that comprises a sample suspected of containing the analyte, a chemiluminescent reagent as described above and a sensitizer reagent capable of generating singlet oxygen. The combination is subjected to conditions for binding of the analyte to the binding partner for the analyte. The sensitizer is activated and the amount of luminescence generated by the chemiluminescent composition is detected wherein the amount of luminescence is related to the amount of the analyte in the sample.
    Type: Application
    Filed: March 12, 2009
    Publication date: September 16, 2010
    Applicant: Siemens Healthcare Diagnostics Inc., a corporation of California
    Inventors: Pratap Singh, Yi Feng Zheng, Liping Geng, Roland Janzen, Carsten Schelp
  • Patent number: 7488608
    Abstract: Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample where one of the reagents for conducting the binding assay comprises a solid support comprising a polysaccharide. The method comprises including in an assay medium for conducting the binding assay a soluble compound comprising a protein linked to a polysaccharide. Also disclosed are methods and compositions for determining the presence and/or amount of an analyte in a sample suspected of containing the analyte. The methods include as reagents a solid support comprising a polysaccharide and a soluble compound comprising a protein linked to a polysaccharide.
    Type: Grant
    Filed: January 3, 2007
    Date of Patent: February 10, 2009
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Zhu Teng, Jeffrey L. Moore, Alan R. Craig, Gary Hickey, Carsten Schelp, Tie Quan Wei
  • Publication number: 20070122850
    Abstract: Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample where one of the reagents for conducting the binding assay comprises a solid support comprising a polysaccharide. The method comprises including in an assay medium for conducting the binding assay a soluble compound comprising a protein linked to a polysaccharide. Also disclosed are methods and compositions for determining the presence and/or amount of an analyte in a sample suspected of containing the analyte. The methods include as reagents a solid support comprising a polysaccharide and a soluble compound comprising a protein linked to a polysaccharide.
    Type: Application
    Filed: January 3, 2007
    Publication date: May 31, 2007
    Applicant: DADE BEHRING INC.
    Inventors: Zhu Teng, Jeffrey Moore, Alan Craig, Gary Hickey, Carsten Schelp, Tie Wei
  • Publication number: 20070082346
    Abstract: The invention relates to methods for the quantitative or qualitative detection of an analyte in an assay and adequate reagents therefor, particularly a homogeneous binding test. According to the invention, an analyte-specific binding partner R1 comprises more than one specific binding point for a specific binding partner X that is associated with a component of a signal-forming system while a second analyte-specific binding partner R2 comprises more than one specific binding point for a specific binding partner Y which is also associated with a component of a signal-forming system.
    Type: Application
    Filed: May 31, 2006
    Publication date: April 12, 2007
    Inventors: Carsten Schelp, Michael Trier, Hrair Kirakossian
  • Patent number: 7179660
    Abstract: A polysaccharide coated carrier having a coating of at least two successive layers of polysaccharide. The first polysaccharide layer spontaneously associates with a second polysaccharide layer and, optionally, the carrier. Each successive layer of polysaccharide spontaneously associates with a preceding layer. Spontaneous association occurs due to the presence of oppositely charged functional groups on each layer of polysaccharide or due to a spontaneous reaction between the functional groups the layers. The carrier may be any surface such as a tube, microtitration plate, bead, particle or the like and is suitable for use in diagnostic or therapeutic methods.
    Type: Grant
    Filed: March 6, 2000
    Date of Patent: February 20, 2007
    Assignee: Dade Behring Marburg GmbH
    Inventors: Hrair Kirakossian, John S. Pease, Carsten Schelp, Marcel R. Pirio, Uwe Stöhr, Andreas Wiegand
  • Patent number: 7172906
    Abstract: Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample where one of the reagents for conducting the binding assay comprises a solid support comprising a polysaccharide. The method comprises including in an assay medium for conducting the binding assay a soluble compound comprising a protein linked to a polysaccharide. Also disclosed are methods and compositions for determining the presence and/or amount of an analyte in a sample suspected of containing the analyte. The methods include as reagents a solid support comprising a polysaccharide and a soluble compound comprising a protein linked to a polysaccharide.
    Type: Grant
    Filed: November 16, 2004
    Date of Patent: February 6, 2007
    Assignee: Dade Behring Inc.
    Inventors: Zhu Teng, Jeffrey L. Moore, Alan R. Craig, Gary Hickey, Carsten Schelp, Tie Quan Wei
  • Publication number: 20060105472
    Abstract: Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample where one of the reagents for conducting the binding assay comprises a solid support comprising a polysaccharide. The method comprises including in an assay medium for conducting the binding assay a soluble compound comprising a protein linked to a polysaccharide. Also disclosed are methods and compositions for determining the presence and/or amount of an analyte in a sample suspected of containing the analyte. The methods include as reagents a solid support comprising a polysaccharide and a soluble compound comprising a protein linked to a polysaccharide.
    Type: Application
    Filed: November 16, 2004
    Publication date: May 18, 2006
    Inventors: Zhu Teng, Jeffrey Moore, Alan Craig, Gary Hickey, Carsten Schelp, Tie Wei
  • Publication number: 20050118642
    Abstract: Methods for quantitatively or qualitatively detecting an analyte in a sample and suitable reagents for this purpose, in particular to a homogeneous binding test, with one analyte-specific binding partner R1 possessing more than one specific binding site for a specific binding partner X, which is associated with a component of a signal-generating system, and a second analyte-specific binding partner R2 possessing more than one specific binding site for a specific binding partner Y, which is likewise associated with a component of a signal-generating system.
    Type: Application
    Filed: December 1, 2003
    Publication date: June 2, 2005
    Inventors: Carsten Schelp, Michael Trier, Hrair Kirakossian
  • Publication number: 20050118727
    Abstract: Methods for quantitatively or qualitatively detecting an analyte in a sample and suitable reagents for this purpose, in particular to a carrier molecule to which one or more analyte-specific binding partner(s) is/are bonded and which possesses additional binding sites for a specific binding partner X or Y which is associated with a component of a signal-generating system, and to the use of such a conjugate, in particular in homogeneous binding tests.
    Type: Application
    Filed: December 1, 2003
    Publication date: June 2, 2005
    Inventors: Carsten Schelp, Pratap Singh, Michael Trier, Harald Ackermann, Susan Swann, Lee Hall