Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: System for automatically manipulating primary packaging in secondary packaging, comprising a robot having at least one robot arm with a clamping gripper installed at a tool centre point, wherein each tool centre point has a force-torque sensor, an image recording module for recording images of at least the upper segment of the primary packaging, comprising at least two stereo cameras for recording 3-D images, and one or more processors for providing a three-dimensional point cloud, controlling the image recording module and controlling the robot on the basis of the analysis of the three-dimensional point cloud and the measurements from the force-torque sensors.

Abstract: A system and method for determining eye surface contour using multifocal keratometry is disclosed. The system includes a light source, a light detector, a processor, a non-transitory machine-readable medium communicatively coupled to the processor, and instructions stored on the non-transitory machine-readable medium. The instructions, when loaded and executed by the processor, cause the processor to project a light, using the light source, onto a plurality of surfaces of an eye; create, using the light detector, an image of a plurality of reflections, each of the plurality of reflections created by reflecting the light off of one of the plurality of surfaces of the eye; determine that the plurality of reflections are in focus in the image; and calculate, based on the determination, a curvature of the plurality of surfaces of the eye based on the image.

Abstract: A system and method for determining eye surface contour using multifocal keratometry is disclosed. The system includes a light source, a light detector, a processor, a non-transitory machine-readable medium communicatively coupled to the processor, and instructions stored on the non-transitory machine-readable medium. The instructions, when loaded and executed by the processor, cause the processor to project a light, using the light source, onto a plurality of surfaces of an eye; create, using the light detector, an image of a plurality of reflections, each of the plurality of reflections created by reflecting the light off of one of the plurality of surfaces of the eye; determine that the plurality of reflections are in focus in the image; and calculate, based on the determination, a curvature of the plurality of surfaces of the eye based on the image.

Abstract: A system and method for determining eye surface contour using multifocal keratometry is disclosed. The system includes a light source, a light detector, a processor, a non-transitory machine-readable medium communicatively coupled to the processor, and instructions stored on the non-transitory machine-readable medium. The instructions, when loaded and executed by the processor, cause the processor to project a light, using the light source, onto a plurality of surfaces of an eye; create, using the light detector, an image of a plurality of reflections, each of the plurality of reflections created by reflecting the light off of one of the plurality of surfaces of the eye; determine that the plurality of reflections are in focus in the image; and calculate, based on the determination, a curvature of the plurality of surfaces of the eye based on the image.

Abstract: A system and method for determining eye surface contour using multifocal keratometry is disclosed. The system includes a light source, a light detector, a processor, a non-transitory machine-readable medium communicatively coupled to the processor, and instructions stored on the non-transitory machine-readable medium. The instructions, when loaded and executed by the processor, cause the processor to project a light, using the light source, onto a plurality of surfaces of an eye; create, using the light detector, an image of a plurality of reflections, each of the plurality of reflections created by reflecting the light off of one of the plurality of surfaces of the eye; determine that the plurality of reflections are in focus in the image; and calculate, based on the determination, a curvature of the plurality of surfaces of the eye based on the image.

Abstract: Flaps, for example leading edge flaps and/or trailing edge flaps of an aircraft wing, are driven and adjusted by respective drive units. Drive shafts of neighboring flaps are coupled to each other by a differential gear. The differential gear is thus coupled to a main drive shaft which is driven by a main drive unit. Additionally, the differential gear is coupled to a secondary drive unit. The main drive power and the secondary drive power and thus the respective flap motions are super-imposable on each other, which permits operating the flaps independently of each other or in synchronism with each other.

Abstract: An aircraft flap (or slat) drive apparatus includes first and second centralized drive units that respectively rotationally drive first and second drive lines in both wings. The first drive line includes shaft segments connected end-to-end by selectively engageable separating devices. The outboard ends of the first and second drive lines are coupled through one of the separating devices, in each wing. At least one actuator mechanism connects each flap to a respective shaft segment of the first drive line, and converts the drive line rotational motion to a flap translational motion. If a component breaks, jams, or otherwise fails, it is isolated by disengaging the two adjacent separating devices with the faulty component therebetween, so that the rest of the apparatus remains functional. Each one or both of the drive units can drive one or more or all of the flaps through the interconnected first and second drive lines.

Abstract: Flaps, for example leading edge flaps and/or trailing edge flaps of an aircraft wing, are driven and adjusted by respective drive units. Drive shafts of neighboring flaps are coupled to each other by a differential gear. The differential gear is thus coupled to a main drive shaft which is driven by a main drive unit. Additionally, the differential gear is coupled to a secondary drive unit. The main drive power and the secondary drive power and thus the respective flap motions are super-imposable on each other, which permits operating the flaps independently of each other or in synchronism with each other.

Abstract: An aircraft flap (or slat) drive apparatus includes first and second centralized drive units that respectively rotationally drive first and second drive lines in both wings. The first drive line includes shaft segments connected end-to-end by selectively engageable separating devices. The outboard ends of the first and second drive lines are coupled through one of the separating devices, in each wing. At least one actuator mechanism connects each flap to a respective shaft segment of the first drive line, and converts the drive line rotational motion to a flap translational motion. If a component breaks, jams, or otherwise fails, it is isolated by disengaging the two adjacent separating devices with the faulty component therebetween, so that the rest of the apparatus remains functional. Each one or both of the drive units can drive one or more or all of the flaps through the interconnected first and second drive lines.

Abstract: The invention relates to a device and a method for transmitting simulation models (11, 18) between simulators (10, 17), the device having a first input/output element (22), to which the simulation model (11) is transmitted from the first simulator (11), having a processing unit (24), which, after the simulation model (11) has been transmitted, separates the model into individual operators (12) and stores the operator association (16), wherein the operators (12) that can be integrated, as external operators (19) and with semantic equivalence, by the second simulator (17) with the aid of the operator association (16) can be compiled into an operator library (12 [sic]), the device further having a second input/output element (23), which outputs the operator library and additionally provides the operator association (16).