Patents by Inventor Carsten Wangnick

Carsten Wangnick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal modification of 2,4-diamino-6-hydroxymethylpteridine hydrobromide
    Patent number: 5910588
    Abstract: A novel crystal modification of the compound 2,4-diamino-6-hydroxymethylpteridine hydrobromide and a process for its preparation and its use for preparing methotrexate. The novel crystal modification of 2,4-diamino-6-hydroxymethylpteridine hydrobromide is distinguished in particular by the fact that only one equivalent of the brominating agent triphenylphosphine dibromide is needed for brominating the 6-hydroxymethyl group. No reaction with the amino groups in the 2 and 4 positions takes place. This facilitates the reaction to give 2,4-diamino-6-pteridinyl derivatives such as methotrexate.
    Type: Grant
    Filed: November 19, 1997
    Date of Patent: June 8, 1999
    Assignee: Heinrich Mack Nachf
    Inventors: Carsten Wangnick, Peter Merrath
  • Crystal modification of 2,4-diamino-6-hydroxymethylpteridine hydrobromide
    Patent number: 5760229
    Abstract: A novel crystal modification of the compound 2,4-diamino-6-hydroxymethylpteridine hydrobromide and a process for its preparation and its use for preparing methotrexate. The novel crystal modification of 2,4-diamino-6-hydroxymethylpteridine hydrobromide is distinguished in particular by the fact that only one equivalent of the brominating agent triphenylphosphine dibromide is needed for brominating the 6-hydroxymethyl group. No reaction with the amino groups in the 2 and 4 positions takes place. This facilitates the reaction to give 2,4-diamino-6-pteridinyl derivatives such as methotrexate.
    Type: Grant
    Filed: February 7, 1996
    Date of Patent: June 2, 1998
    Assignee: Heinric Mack Nachf
    Inventors: Carsten Wangnick, Peter Merrath