Abstract: A method is disclosed for differentiated sequestration of substances of different substance groups A and B in a sulfated and/or sulfonated hydrogel while simultaneously releasing substances of substance group A or B from the sulfated and/or sulfonated hydrogel into a biofluid. The sulfated and/or sulfonated hydrogel is selected from hydrogels of Type 1, Type 2, Type 3, Type 4 and consist of uncharged and charged components. The charged components are characterized by calculating the number of sulfated or sulfonated groups per repeat unit divided by the molecular mass of the repeat unit, for each of Type 1, 2, 3 and 4. Swollen hydrogels have a different concentration of sulfated or sulfonated groups in mmol/ml for Type 1, Type 2, Type 3 and Type 4. The concentration of substances of each substance group A and group B in the biofluid is influenced by the selection of the type of hydrogel.

Abstract: A modular implantable device for the macroencapsulation of cells, comprising: —at least one bracket configured for accommodating at least one cell module within the device, at least one oxygen module, and at least one immuno-isolating membrane, wherein the at least one oxygen module is contained within the device in a shell formed by the at least one bracket and the at least one immuno-isolating membrane, optionally together with the at least one cell module.

Abstract: A method is disclosed for differentiated sequestration of substances of different substance groups A and B in a sulfated and/or sulfonated hydrogel while simultaneously releasing substances of substance group A or B from the sulfated and/or sulfonated hydrogel into a biofluid. The sulfated and/or sulfonated hydrogel is selected from hydrogels of Type 1, Type 2, Type 3, Type 4 and consist of uncharged and charged components. The charged components are characterized by calculating the number of sulfated or sulfonated groups per repeat unit divided by the molecular mass of the repeat unit, for each of Type 1, 2, 3 and 4. Swollen hydrogels have a different concentration of sulfated or sulfonated groups in mmol/ml for Type 1, Type 2, Type 3 and Type 4. The concentration of substances of each substance group A and group B in the biofluid is influenced by the selection of the type of hydrogel.

Abstract: This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates.

Abstract: The present invention relates to therapeutic compositions containing hydrogel particles, at least one hyaluronic acid component and at least one pharmaceutically acceptable excipient as well as methods for producing therapeutic compositions and the use thereof for treating arthritis.

Abstract: A configurable hydrogel material for sequestration of bioactive substances in the hydrogel material and/or release of bioactive substances from the hydrogel material is disclosed. The invention further relates to a method for determining and making available a configuration for a hydrogel material for sequestration and/or release of bioactive substances.

Abstract: A molecular assembly having a structural formation of amphiphilic molecules is disclosed where the amphiphilic molecules are selected from a group containing amphiphilic molecules which a) have a hydrophobic moiety and a hydrophilic moiety b) are soluble in a polar aprotic solvent and form self-organizing layer structures in the absence of the polar aprotic solvent, and c) orient molecularly in formed layer structures at an interfacial layer, or in an aqueous environment. The amphiphilic molecules in the formed layer structure are in contact with an aqueous environment. A method for coating a solid surface with a molecular assembly is also disclosed, wherein the amphiphilic molecules are dissolved in a polar aprotic solvent, and resulting solution is applied to a solid surface by spin coating.

Abstract: A molecular assembly having a structural formation of amphiphilic molecules is disclosed where the amphiphilic molecules are selected from a group containing amphiphilic molecules which a) have a hydrophobic moiety and a hydrophilic moiety b) are soluble in a polar aprotic solvent and form self-organizing layer structures in the absence of the polar aprotic solvent, and c) orient molecularly in formed layer structures at an interfacial layer, or in an aqueous environment. The amphiphilic molecules in the formed layer structure are in contact with an aqueous environment. A method for coating a solid surface with a molecular assembly is also disclosed, wherein the amphiphilic molecules are dissolved in a polar aprotic solvent, and resulting solution is applied to a solid surface by spin coating.

Abstract: A method for detecting and influencing an uptake of bioactive substances in a hydrogel material and/or release of bioactive substances from the hydrogel material, wherein the hydrogel material is a polymer network formed from charged and uncharged building blocks, the affinity of which network for bioactive substances is configurable by parameters defining the charged building blocks, and whose electrical charge storage capacity depend on interaction with the hydrogel binding of bioactive substances to the hydrogel material. When the hydrogel material is contacted with a biofluid, a change in electrical resistance and/or a change in charge storage capacity of the hydrogel material is detected. Uptake or a release of bioactive substances from the hydrogel material into the biofluid is determined by change in electrical resistance. The invention further relates to a suitable electrically conductive hydrogel material.

Abstract: The invention relates to a method for the formation of renal tubules by embedding individual renal cells into a synthetic hydrogel, which is based on polyethylene glycol as a component, and the culturing of the cells until tubule structures are formed. The culturing can be continued until the obtained tubule structures correspond in terms of size, structure, morphology and functionality to adult human renal tubules or are at least similar thereto.

Abstract: The invention relates to a hydrogel matrix comprising a mixture of a covalent peptide-polymer conjugate and an oligosaccharide; wherein the oligosaccharide is a highly negatively charged sulfated oligosaccharide selected from the group consisting of heparin, dextran sulfate, ?-cyclodextrin sulfate, ?-cyclodextrin sulfate and ?-cyclodextrin sulfate; wherein said polymer comprised in said peptide-polymer conjugate is a linear or multi-arm polyethylene glycol; wherein said peptide comprised in said peptide-polymer conjugate is a peptide, which consists of an amino acid sequence selected from the group consisting of SEQ ID NO.4, SEQ ID NO.5, SEQ ID NO. 18 and SEQ ID NO. 19; and wherein said hydrogel matrix is configured in the form of an oligosaccharide/peptide/polymer system, in which said peptide is chemically conjugated to the polymer such that the hydrogel is obtained by mixing the peptide-polymer conjugate and the oligosaccharide.

Abstract: The invention relates to a hydrogel matrix comprising a mixture of a covalent peptide-polymer conjugate and an oligosaccharide; wherein the oligosaccharide is a highly negatively charged sulfated oligosaccharide selected from the group consisting of heparin, dextran sulfate, ?-cyclodextrin sulfate, ?-cyclodextrin sulfate and ?-cyclodextrin sulfate; wherein said polymer comprised in said peptide-polymer conjugate is a linear or multi-arm polyethylene glycol; wherein said peptide comprised in said peptide-polymer conjugate is a peptide, which consists of an amino acid sequence selected from the group consisting of SEQ ID NO.4, SEQ ID NO.5, SEQ ID NO. 18 and SEQ ID NO. 19; and wherein said hydrogel matrix is configured in the form of an oligosaccharide/peptide/polymer system, in which said peptide is chemically conjugated to the polymer such that the hydrogel is obtained by mixing the peptide-polymer conjugate and the oligosaccharide.

Abstract: Device D for cultivating cell cultures C, wherein said device D has a surface O and comprises on its surface O at least one polymer P wherein said polymer P is a copolymer of at least one monomer M and at least one ester E of (meth)acrylic acid and polyethylene oxide, wherein said monomer M is different from ester E and has at least one ethylenically unsaturated double bond.

Abstract: A method is disclosed for the differentiated sequestration of substances of different substance groups A and B in a sulfated and/or sulfonated hydrogel while simultaneously releasing substances of substance group A or B from the sulfated and/or sulfonated hydrogel into the biofluid. The sulfated and/or sulfonated hydrogel is selected from a group of hydrogels of Type 1, 2, 3, 4 and consist of uncharged and charged components. The charged components are characterized by calculating the number of sulfated or sulfonated groups per repeat unit divided by the molecular mass of the repeat unit, for each of Type 1 2 3 and 4. The swollen hydrogels have a concentration of sulfated or sulfonated groups in mmol/ml for Type 1, Type 2, Type 3 and Type 4. The concentration of substances of each substance group A and group B in the biofluid is influenced by the selection of the type of hydrogel.

Abstract: The invention relates to a method for forming a functional network of human neuronal and glial cells, wherein the cells are introduced into a synthetic hydrogel system with the components polyethylene glycol (PEG) and heparin and are cultivated therein. The cells are introduced into the PEG heparin hydrogel system together with one of the gel components, either PEG or heparin, with which the cells were previously mixed such that the cells are already located in the hydrogel system during the formation of the three-dimensional hydrogel.

Abstract: The invention relates to a method for the formation of renal tubules by embedding individual renal cells into a synthetic hydrogel, which is based on polyethylene glycol as a component, and the culturing of the cells until tubule structures are formed. The culturing can be continued until the obtained tubule structures correspond in terms of size, structure, morphology and functionality to adult human renal tubules or are at least similar thereto.

Abstract: A polymer-based material having covalently bonded enzymatically degradable peptide sequences not degradable by the biological and metabolic activity of cells and tissues is disclosed, wherein the peptide sequences are incorporated into the polymer-based material or conjugated to the polymer-based material. The peptide sequence can be part of the three-dimensional or two-dimensional structure of the polymer-based material. A controlled degradation of a covalent bond in the peptide sequence is effected. Use of such polymer-based material for an in vitro production of cell cultures or tissues or organs, for an in vivo stabilization of donated cells, tissues or organs is also disclosed. An adhesive bond between the material and the sample, i.e. cells, tissues, or organs is controlledly degradable without destroying the integrity of the sample.

Abstract: The subject matter of the invention is a remote-controllable, disk-shaped aircraft platform, comprising a platform housing and at least one transport housing, the platform housing having a plurality of motor-driven, horizontally aligned rotors, each rotor being connected via a support arm to a support structure holding the support arms of the rotors, the support structure being centrally arranged in the platform housing, the support structure accommodating at least one transport housing in a vibrationally isolated manner.

Abstract: The subject matter of the invention is a remote-controllable, disk-shaped aircraft platform, comprising a platform housing and at least one transport housing, the platform housing having a plurality of motor-driven, horizontally aligned rotors, each rotor being connected via a support arm to a support structure holding the support arms of the rotors, the support structure being centrally arranged in the platform housing, the support structure accommodating at least one transport housing in a vibrationally isolated manner.

Abstract: A flight system comprising an aircraft equipped with at least four rotors and having a payload, a number of rotors rotating in one direction and a number of rotors rotating in the other direction, as well as a remote control, the aircraft being connected to the remote control, so as to transmit data, via respective transmitter/receiver units, both the aircraft and the remote control having a data processing device connected to the respective transmitter/receiver unit, both the aircraft and the remote control having the same sensors for flight attitude detection, where, when there is an angle change in the remote control around its X- and/or Y- and/or Z-axis, the amount of the angle change correlates with a definable speed of the aircraft, the speed specified according to the angle change being transmitted as a target value of the data processing device of the aircraft and/or of the remote control.