Patents by Inventor Carston R. Wagner

Carston R. Wagner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MASKED SINGLE-DOMAIN ANTIBODIES AND METHODS THEREOF
    Publication number: 20230406927
    Abstract: Certain embodiments of the invention provide a masked single-domain antibody as described herein, as well as methods of use thereof. Certain embodiments of the invention provide a masked CSAN as described herein, as well as methods of use thereof.
    Type: Application
    Filed: May 1, 2023
    Publication date: December 21, 2023
    Applicant: Regents of the University of Minnesota
    Inventors: Carston R. Wagner, Abhishek Kulkarni
  • Pharmaceutical compounds and uses thereof
    Patent number: 11439656
    Abstract: Described herein are small molecule cap-dependent inhibitors, including the compound of the formula: which compounds that can induce the accumulation of the p53 tumor suppressor protein in cancer cells that still express wild-type p53, as well as methods of using those compounds to, among other things, treat neuroblastoma, pediatric glioblastoma multiforme or breast cancer.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: September 13, 2022
    Assignee: Regents of the University of Minnesota
    Inventors: DaQing Yang, Carston R. Wagner, Aniekan Okon
  • EpCAM targeted polypeptides, conjugates thereof, and methods of use thereof
    Patent number: 10787499
    Abstract: Certain embodiments of the invention provide epithelial cell adhesion molecule (EpCAM) binding polypeptides, as well as conjugates and CSANs comprising such polypeptides. Additionally, certain embodiments of the invention also provide methods of using such polypeptides and compounds for molecular imaging and molecularly targeted therapies.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: September 29, 2020
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Benjamin Hackel, Carston R. Wagner, Lawrence A. Stern, Clifford Csizmar
  • NUCLEOSIDES WITH ANTIVIRAL AND ANTICANCER ACTIVITY
    Publication number: 20200095273
    Abstract: The invention provides a a compound of formula I: wherein R1-R6 and X have any of the values described herein, as well as pharmaceutical compoustions comprising such compounds and therapeutic methods comprising the administration of such compounds.
    Type: Application
    Filed: February 27, 2019
    Publication date: March 26, 2020
    Inventor: Carston R. Wagner
  • PHARMACEUTICAL COMPOUNDS AND USES THEREOF
    Publication number: 20200069712
    Abstract: Described herein are compounds pharmaceutically acceptable salts, isomers, mixture of isomers, crystalline forms, non-crystalline forms, hydrates, or solvates thereof, as well as methods using those compounds to, among other things, treat cancer.
    Type: Application
    Filed: August 30, 2019
    Publication date: March 5, 2020
    Inventors: DaQing Yang, Carston R. Wagner
  • Sulfamide and sulfamate inhibitors of hHint1
    Patent number: 10513520
    Abstract: Embodiments provide, among things, compounds of the formula I: wherein Het, Y, Rx, Z, X, R1-R3, R6, and R7 are defined herein; and methods for using such compounds to reduce pain (e.g., neuronal pain), treat a mammal's addiction to nicotine or anti-pain drugs, and increase a mammal's sensitivity to drugs that bind MOR or NMDAR.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: December 24, 2019
    Assignee: Regents of the University of Minnesota
    Inventors: Carston R. Wagner, Rachit Shah
  • NUCLEOSIDES WITH ANTIVIRAL AND ANTICANCER ACTIVITY
    Publication number: 20180258131
    Abstract: The invention provides a compound of formula I: wherein R1-R6 and X have any of the values described herein, as well as pharmaceutical compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.
    Type: Application
    Filed: October 18, 2017
    Publication date: September 13, 2018
    Inventor: Carston R. Wagner
  • EpCAM TARGETED POLYPEPTIDES, CONJUGATES THEREOF, AND METHODS OF USE THEREOF
    Publication number: 20180251524
    Abstract: Certain embodiments of the invention provide epithelial cell adhesion molecule (EpCAM) binding polypeptides, as well as conjugates and CSANs comprising such polypeptides. Additionally, certain embodiments of the invention also provide methods of using such polypeptides and compounds for molecular imaging and molecularly targeted therapies.
    Type: Application
    Filed: February 13, 2018
    Publication date: September 6, 2018
    Inventors: Benjamin Hackel, Carston R. Wagner, Lawrence A. Stern, Clifford Csizmar
  • SULFAMIDE AND SULFAMATE INHIBITORS OF hHint1
    Publication number: 20180065965
    Abstract: Embodiments provide, among things, compounds of the formula I and methods for using such compounds to reduce pain (e.g., neuronal pain), treat a mammal's addiction to nicotine or anti-pain drugs, and increase a mammal's sensitivity to drugs that bind MOR or NMDAR.
    Type: Application
    Filed: August 9, 2017
    Publication date: March 8, 2018
    Inventors: Carston R. Wagner, Rachit Shah
  • Methods of making and using chemically self assembled-nanorings
    Patent number: 9499800
    Abstract: Provided herein are compounds, conjugates and methods for making lipid-chemically self-assembled nanorings (Lipid-CSANs) and using them to treat diseases and modify cell surfaces.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: November 22, 2016
    Assignee: Regents of the University of Minnesota
    Inventor: Carston R. Wagner
  • Methods of making and using nanostructures
    Patent number: 9486535
    Abstract: The invention provides methods for attaching drugs, dyes or radiolabels to bis-MTX. This method can be used to prepare bis-MTX analogs that can be used to deliver agents, such as nanoparticles, drugs, dyes or radiolabels, to cells.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: November 8, 2016
    Assignee: TYCHON BIOSCIENCE, LLC
    Inventors: Carston R. Wagner, Jae Chul Lee, Sidath C. Kumarapperuma
  • NUCLEOSIDES WITH ANTIVIRAL AND ANTICANCER ACTIVITY
    Publication number: 20160159845
    Abstract: The invention provides a compound of formula I: wherein R1-R6 and X have any of the values described herein, as well as pharmaceutical compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.
    Type: Application
    Filed: February 16, 2016
    Publication date: June 9, 2016
    Inventor: Carston R. Wagner
  • METHODS OF MAKING AND USING CHEMICALLY SELF ASSEMBLED-NANORINGS
    Publication number: 20150343082
    Abstract: Provided herein are compounds, conjugates and methods for making lipid-chemically self-assembled nanorings (Lipid-CSANs) and using them to treat diseases and modify cell surfaces.
    Type: Application
    Filed: December 23, 2014
    Publication date: December 3, 2015
    Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventor: Carston R. Wagner
  • NUCLEOSIDES WITH ANTIVIRAL AND ANTICANCER ACTIVITY
    Publication number: 20150025220
    Abstract: The invention provides a compound of formula I: wherein R1-R6 and X have any of the values described herein, as well as pharmaceutical compostions comprising such compounds and therapeutic methods comprising the administration of such compounds.
    Type: Application
    Filed: July 21, 2014
    Publication date: January 22, 2015
    Inventor: Carston R. Wagner
  • METHODS OF MAKING AND USING NANOSTRUCTURES
    Publication number: 20150017189
    Abstract: The invention provides methods for attaching drugs, dyes or radiolabels to bis-MTX. This method can be used to prepare bis-MTX analogs that can be used to deliver agents, such as nanoparticles, drugs, dyes or radiolabels, to cells.
    Type: Application
    Filed: January 18, 2013
    Publication date: January 15, 2015
    Inventors: Carston R. Wagner, Jae Chul Lee, Sidath C. Kumarapperuma
  • Nucleosides with antiviral and anticancer activity
    Patent number: 8815830
    Abstract: The invention provides a compound of formula (I), wherein R1-R6 and X have any of the values described, as well as pharmaceutical compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: August 26, 2014
    Assignee: Regents of the University of Minnesota
    Inventor: Carston R. Wagner
  • NUCLEOSIDES WITH ANTIVIRAL AND ANTICANCER ACTIVITY
    Publication number: 20140213543
    Abstract: The invention provides a compound of formula (1), wherein R1-R6 and X have any of the values described, as well as pharmaceutical compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.
    Type: Application
    Filed: March 28, 2014
    Publication date: July 31, 2014
    Applicant: Regents of the University of Minnesota
    Inventor: Carston R. Wagner
  • Nucleosides with antiviral and anticancer activity
    Patent number: 8765935
    Abstract: The invention provides a compound of formula (I), wherein R1-R6 and X have any of the values described, as well as pharmaceutical compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.
    Type: Grant
    Filed: January 29, 2013
    Date of Patent: July 1, 2014
    Assignee: Regents of the University of Minnesota
    Inventor: Carston R. Wagner
  • Protein nanorings
    Patent number: 8580921
    Abstract: The invention provides protein nanorings.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: November 12, 2013
    Assignee: University of Minnesota
    Inventor: Carston R. Wagner
  • Nucleosides with antiviral and anticancer activity
    Patent number: 8399428
    Abstract: The invention provides a compound of formula (I), wherein R1-R6 and X have any of the values described, as well as pharmaceutical compositions comprising such compounds and therapeutic methods comprising the administration of such compounds.
    Type: Grant
    Filed: December 8, 2005
    Date of Patent: March 19, 2013
    Assignee: Regents of the University of Minnesota
    Inventor: Carston R. Wagner