Abstract: A sleeping chamber apparatus for mounting over a bed to isolate a sleeping space from a room environment has a headboard joined to a footboard by a U-shaped enclosure. The enclosure comprises a pair of spaced-apart, vertical side panels joined together and integral with a horizontal cover panel. The headboard, footboard and enclosure fully enclose and seal the sleeping space when the apparatus is positioned over the bed with the headboard positioned at a head of the bed and with the footboard positioned at a foot of the bed, and with the side panels positioned along sides of the bed in contact with an up-facing surface of the bed. A head manifold and a foot manifold bring air into and drive air out of the sleeping space. An air conditioning machine engages with the head manifold drawing in room environment air and delivering conditioned air to the head manifold.