Patents by Inventor Cary Francis OPEL

Cary Francis OPEL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treating cancer cells expressing tumor-associated integrins
    Patent number: 10888603
    Abstract: The present invention provides a method of treating cancer with a combination of IL-2 (e.g., extended-PK IL-2), an integrin-binding-Fc fusion protein, and a cancer vaccine. The methods of the invention can be used to treat a broad range of cancer types.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: January 12, 2021
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Massachusetts Institute of Technology
    Inventors: Karl Dane Wittrup, Darrell J. Irvine, Cary Francis Opel, Kelly Dare Moynihan, Jennifer R. Cochran, Byron Hua Kwan
  • SYNERGISTIC TUMOR TREATMENT WITH IL-2, AN INTEGRIN-BINDING-FC FUSION PROTEIN, AND A CANCER VACCINE
    Publication number: 20190054145
    Abstract: The present invention provides a method of treating cancer with a combination of IL-2 (e.g., extended-PK IL-2), an integrin-binding-Fc fusion protein, and a cancer vaccine. The methods of the invention can be used to treat a broad range of cancer types.
    Type: Application
    Filed: February 10, 2017
    Publication date: February 21, 2019
    Inventors: Karl Dane WITTRUP, Darrell J. IRVINE, Cary Francis OPEL, Kelly Dare MOYNIHAN, Jennifer R. COCHRAN, Byron Hua KWAN
  • SYNERGISTIC TUMOR TREATMENT WITH IL-2, A THERAPEUTIC ANTIBODY, AND A CANCER VACCINE
    Publication number: 20170224777
    Abstract: The present invention provides a method of treating cancer with a combination of IL-2 (e.g., extended-PK IL-2), a therapeutic antibody or fragment thereof, and a cancer vaccine. The methods of the invention can be used to treat a broad range of cancer types.
    Type: Application
    Filed: August 12, 2015
    Publication date: August 10, 2017
    Inventors: Karl Dane WITTRUP, Darrell IRVINE, Cary Francis OPEL, Kelly Dare MOYNIHAN
  • SYNERGISTIC TUMOR TREATMENT WITH IL-2, A THERAPEUTIC ANTIBODY, AND AN IMMUNE CHECKPOINT BLOCKER
    Publication number: 20170216403
    Abstract: The present invention provides a method of treating cancer with a combination of IL-2 (e.g., extended-PK IL-2), a therapeutic antibody or fragment thereof, and an immune checkpoint blocker. The methods of the invention can be used to treat a broad range of cancer types.
    Type: Application
    Filed: August 12, 2015
    Publication date: August 3, 2017
    Inventors: Karl Dane WITTRUP, Darrell IRVINE, Cary Francis OPEL, Kelly Dare MOYNIHAN
  • SYNERGISTIC TUMOR TREATMENT WITH EXTENDED-PK IL-2 AND ADOPTIVE CELL THERAPY
    Publication number: 20150017120
    Abstract: The present invention provides a method of enhancing adoptive cell therapy (ACT) by administering an extended-pharmacokinetic (PK) interleukin (IL)-2 to a cancer subject receiving ACT, optionally in combination with a therapeutic antibody. Methods of treating cancer and promoting tumor regression are also provided.
    Type: Application
    Filed: June 13, 2014
    Publication date: January 15, 2015
    Inventors: Karl Dane WITTRUP, Cary Francis OPEL, Eric Franklin ZHU, Shuning GAI