Patents by Inventor CARYN R. HALE

CARYN R. HALE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROKARYOTIC RNAi-LIKE SYSTEM AND METHODS OF USE
    Publication number: 20160355816
    Abstract: Provided herein are methods for inactivating a target polynucleotide. The methods use a psiRNA having a 5? region and a 3? region. The 5? region includes, but is not limited to, 5 to 10 nucleotides chosen from a repeat from a CRISPR locus immediately upstream of a spacer. The 3? region is substantially complementary to a portion of the target polynucleotide. The methods may be practiced in a prokaryotic microbe or in vitro. Also provided are polypeptides that have endonuclease activity in the presence of a psiRNA and a target polynucleotide, and methods for using the polypeptides.
    Type: Application
    Filed: June 14, 2016
    Publication date: December 8, 2016
    Inventors: Rebecca M. Terns, Michael P. Terns, Caryn R. Hale
  • Prokaryotic RNAi-like system and methods of use
    Patent number: 9422553
    Abstract: Provided herein are methods for inactivating a target polynucleotide. The methods use a psiRNA having a 5? region and a 3? region. The 5? region includes, but is not limited to, 5 to 10 nucleotides chosen from a repeat from a CRISPR locus immediately upstream of a spacer. The 3? region is substantially complementary to a portion of the target polynucleotide. The methods may be practiced in a prokaryotic microbe or in vitro. Also provided are polypeptides that have endonuclease activity in the presence of a psiRNA and a target polynucleotide, and methods for using the polypeptides.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: August 23, 2016
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Rebecca M. Terns, Michael P. Terns, Caryn R. Hale
  • PROKARYOTIC RNAi-LIKE SYSTEM AND METHODS OF USE
    Publication number: 20140093941
    Abstract: Provided herein are methods for inactivating a target polynucleotide. The methods use a psiRNA having a 5? region and a 3? region. The 5? region includes, but is not limited to, 5 to 10 nucleotides chosen from a repeat from a CRISPR locus immediately upstream of a spacer. The 3? region is substantially complementary to a portion of the target polynucleotide. The methods may be practiced in a prokaryotic microbe or in vitro. Also provided are polypeptides that have endonuclease activity in the presence of a psiRNA and a target polynucleotide, and methods for using the polypeptides.
    Type: Application
    Filed: September 12, 2013
    Publication date: April 3, 2014
    Applicant: University of Georgia Research Foundation, Inc.
    Inventors: REBECCA M. TERNS, MICHAEL P. TERNS, CARYN R. HALE