Patents by Inventor Casey Christopher Case

Casey Christopher Case has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oligodendrocyte progenitor cell compositions
    Patent number: 11920155
    Abstract: Compositions comprising a population of oligodendrocyte progenitor cells (OPCs), as well as methods of making and using the same, are provided. In one aspect, a container comprising a composition, where the composition comprises a population of cells comprising a plurality of OPCs, and where the population of cells comprises less than 15% undesirable cell types is provided. In another aspect, the population of cells comprises less than 15% undesirable epithelial lineage cells. In yet another aspect, the population of cells comprises less than 2% K7 positive cells. In an aspect, a population of cells comprising a plurality of oligodendrocyte progenitor cells is capable of forming less than one epithelial cyst per 100,000 cells in a cyst assay is provided. An even further aspect of the present disclosure is a container comprising a composition, where the composition comprising a plurality of oligodendrocyte progenitor cells is useful in treating treat stroke, spinal cord injury, and multiple sclerosis.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: March 5, 2024
    Assignee: ASTERIAS BIOTHERAPEUTICS, INC.
    Inventors: Erik Michael Whiteley, Uzma Shoukat-Mumtaz, Rashi Srivastava, Nathan Charles Manley, Casey Christopher Case
  • OLIGODENDROCYTE PROGENITOR CELL COMPOSITIONS
    Publication number: 20210189335
    Abstract: Compositions comprising a population of oligodendrocyte progenitor cells (OPCs), as well as methods of making and using the same, are provided. In one aspect, a container comprising a composition, where the composition comprises a population of cells comprising a plurality of OPCs, and where the population of cells comprises less than 15% undesirable cell types is provided. In another aspect, the population of cells comprises less than 15% undesirable epithelial lineage cells. In yet another aspect, the population of cells comprises less than 2% K7 positive cells. In an aspect, a population of cells comprising a plurality of oligodendrocyte progenitor cells is capable of forming less than one epithelial cyst per 100,000 cells in a cyst assay is provided. An even further aspect of the present disclosure is a container comprising a composition, where the composition comprising a plurality of oligodendrocyte progenitor cells is useful in treating treat stroke, spinal cord injury, and multiple sclerosis.
    Type: Application
    Filed: March 30, 2017
    Publication date: June 24, 2021
    Applicant: Asterias Biotherapeutics, Inc.
    Inventors: Erik Michael WHITELEY, Uzma SHOUKAT-MUMTAZ, Rashi SRIVASTAVA, Nathan Charles MANLEY, Casey Christopher CASE
  • Regulation of endogenous gene expression in cells using zinc finger proteins
    Patent number: 9491934
    Abstract: The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
    Type: Grant
    Filed: May 23, 2011
    Date of Patent: November 15, 2016
    Assignee: Sangamo BioSciences, Inc.
    Inventors: George Norbert Cox, III, Casey Christopher Case, Stephen P. Eisenberg, Eric Edward Jarvis, Sharon Kaye Spratt
  • Regulation of endogenous gene expression in cells using zinc finger proteins
    Publication number: 20120294838
    Abstract: The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
    Type: Application
    Filed: May 23, 2011
    Publication date: November 22, 2012
    Inventors: George Norbert Cox III, Casey Christopher Case, Stephen P. Eisenberg, Eric Edward Jarvis, Sharon Kaye Spratt
  • Repressing endogenous CCR5 gene expression in cells using engineered zinc finger proteins
    Patent number: 8268618
    Abstract: The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
    Type: Grant
    Filed: August 16, 2006
    Date of Patent: September 18, 2012
    Assignee: Sangamo BioSciences, Inc.
    Inventors: George Norbert Cox, III, Casey Christopher Case, Stephen P. Eisenberg, Eric Edward Jarvis, Sharon Kaye Spratt
  • Regulation of endogenous gene expression in cells using zinc finger proteins
    Publication number: 20110247087
    Abstract: The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
    Type: Application
    Filed: May 23, 2011
    Publication date: October 6, 2011
    Inventors: George Norbert Cox, III, Casey Christopher Case, Stephen P. Eisenberg, Eric Edward Jarvis, Sharon Kaye Spratt
  • Regulation of endogenous gene expression in cells using zinc finger proteins
    Patent number: 7985887
    Abstract: The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
    Type: Grant
    Filed: August 17, 2006
    Date of Patent: July 26, 2011
    Assignee: Sangamo BioSciences, Inc.
    Inventors: George Norbert Cox, III, Casey Christopher Case, Stephen P. Eisenberg, Eric Edward Jarvis, Sharon Kaye Spratt
  • Alteration of tumor growth using zinc finger proteins
    Publication number: 20100279406
    Abstract: The present invention provides methods for altering tumor growth using zinc finger proteins.
    Type: Application
    Filed: September 20, 2006
    Publication date: November 4, 2010
    Inventors: George Norbert Cox, III, Casey Christopher Case, Stephen P. Eisenberg, Eric Edward Jarvis, Sharon Kaye Spratt
  • Regulation of endogenous gene expression in cells using zinc finger proteins
    Publication number: 20100261271
    Abstract: The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
    Type: Application
    Filed: September 14, 2006
    Publication date: October 14, 2010
    Inventors: George Norbert Cox, III, Casey Christopher Case, Stephen P. Eisenberg, Eric Edward Jarvis, Sharon Kaye Spratt
  • Regulation of endogenous gene expression in cells using zinc finger proteins
    Patent number: 7163824
    Abstract: The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
    Type: Grant
    Filed: August 15, 2002
    Date of Patent: January 16, 2007
    Assignee: Sangamo Biosciences, Inc.
    Inventors: George Norbert Cox, III, Casey Christopher Case, Stephen P. Eisenberg, Eric Edward Jarvis, Sharon Kaye Spratt
  • Ligand-controlled regulation of endogenous gene expression
    Patent number: 7070934
    Abstract: Disclosed herein are compositions comprising an engineered zinc finger protein and a nuclear hormone receptor transcriptional control domain, polynucleotides encoding one or more components of the compositions, methods of making the compositions and methods of using these compositions, for example to modulate gene expression and/or to generate transgenic plants or animals.
    Type: Grant
    Filed: June 5, 2003
    Date of Patent: July 4, 2006
    Assignee: Sangamo Biosciences, Inc.
    Inventors: George Norbert Cox, III, Casey Christopher Case, Stephen P. Eisenberg, Eric Edward Jarvis, Sharon Kaye Spratt
  • Regulation of endogenous gene expression in cells using zinc finger proteins
    Patent number: 6979539
    Abstract: The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: December 27, 2005
    Assignee: Sangamo BioSciences, Inc.
    Inventors: George Norbert Cox, III, Casey Christopher Case, Stephen P. Eisenberg, Eric Edward Jarvis, Sharon Kaye Spratt
  • Regulation of endogenous gene expression in cells using zinc finger proteins
    Patent number: 6824978
    Abstract: The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
    Type: Grant
    Filed: November 3, 2000
    Date of Patent: November 30, 2004
    Assignee: Sangamo Biosciences, Inc.
    Inventors: George Norbert Cox, III, Casey Christopher Case, Stephen P. Eisenberg, Eric Edward Jarvis, Sharon Kaye Spratt
  • Regulation of endogenous gene expression in cells using zinc finger proteins
    Publication number: 20030087817
    Abstract: The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
    Type: Application
    Filed: July 2, 2001
    Publication date: May 8, 2003
    Applicant: Sangamo BioSciences, Inc.
    Inventors: George Norbert Cox, Casey Christopher Case, Stephen P. Eisenberg, Eric Edward Jarvis, Sharon Kaye Spratt
  • Regulation of endogenous gene expression in cells using zinc finger proteins
    Patent number: 6534261
    Abstract: The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
    Type: Grant
    Filed: January 12, 1999
    Date of Patent: March 18, 2003
    Assignee: Sangamo BioSciences, Inc.
    Inventors: George Norbert Cox, III, Casey Christopher Case, Stephen P. Eisenberg, Eric Edward Jarvis, Sharon Kaye Spratt